Vitamin D intake and incidence of multiple sclerosis

Abstract

These results support a protective effect of vitamin D intake on risk of developing MS.

维生素d 在免疫反应和自身免疫性疾病特别是多发性硬化中的作用

“…[49][50][51][52][53][54][55][56][57][58][59] Cancer breast, prostate, colorectal, lung, endometrial cancers, etc. [10,11] Cardiovascular diseases atherosclerosis, coronary heart disease, congestive heart failure, hypertension, diabetes, etc.…”

“…Both laboratory and clinical studies have provided evidence that vitamin D deficiency is an important environmental factor that can increase the prevalence of certain autoimmune diseases, such as MS [55][56][57] , Crohn disease [58] , diabetes mellitus [59,60] , systemic lupus erythematosus (SLE) [61,62] , asthma [63] , RA [64] , Sjögren's syndrome, systemic vasculitis and antiphospholipid syndrome [65] . A correlation between reduced intake of vitamin D and prevalence of the diseases can be found, which raises the possibility that serum vitamin D level is important for the pathogenesis of autoimmune diseases.…”

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

“…More recently, observational studies have also reported that vitamin D intake is inversely associated with the incidence of a number of conditions, including cancer and autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and type I diabetes mellitus (Bostick et al, 1993;Hypponen et al, 2001;Merlino et al, 2004;Munger et al, 2004).…”

The new role of vitamin D

“…In the Nurses' Health Study I and II, women in the highest quintile of vitamin D intake had a 40% reduced rate of developing multiple sclerosis, and in the Woman's Iowa Health Study, vitamin D intake was inversely associated with rheumatoid arthritis. 8,9 Melamed and his team from John Hopkins University analysed data collected from 13 331 adults during a six-year period and followed up for nine years. People with vitamin D levels less than 17.8 ng/mL had a 26% increased rate of death from any cause, compared to people with the highest vitamin D levels (more than 32.1 ng/mL).…”