Vitamin D Insufficiency Is Associated With Diabetes Risk in Native American Children

Nsiah-Kumi, Phyllis A.; Erickson, Judi; Beals, Jennifer L.; Ogle, Eric A.; Whiting, Mary; Brushbreaker, Connie; Borgeson, Claudia D.; Qiu, Fang; Yu, Fang; Larsen, Jennifer L.

doi:10.1177/0009922811417290

Cited by 31 publications

(33 citation statements)

References 30 publications

(43 reference statements)

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“…In all four studies irrespective of age, sex, weight, and race/ ethnicity, 25(OH)D was inversely associated with SBP. Similar findings were reported in studies with smaller numbers of subjects (27)(28)(29)(30).…”

Section: Vitamin D Deficiency and Its Relation To Mets Or Its Componentssupporting

confidence: 91%

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Challa

Makariou

Siomou

2015

Journal of Pediatric Endocrinology and Metabolism

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Among children and adolescents, metabolic syndrome (MetS) is more common than previously believed. Hence, any information on the relation between vitamin D insufficiency/deficiency and insulin resistance (IR) in this population with risk of developing MetS is of great importance. This review analyzes and evaluates the existing evidence from cross-sectional, observational, and retrospective studies concerning the effect of vitamin D insufficiency/deficiency on MetS as a whole or on its various components. Most data show that insufficient vitamin D status is associated with increased prevalence of MetS or its individual components, mainly blood pressure and IR, often independent of overall obesity or abdominal adiposity. The implications of these findings could be associated with increased risk for developing cardiovascular disease and type 2 diabetes mellitus in later life. The very few randomized control trials examining any possible beneficial effects of vitamin D supplementation are also included.

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Section: Vitamin D Deficiency and Its Relation To Mets Or Its Componentssupporting

confidence: 91%

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Challa

Makariou

Siomou

2015

Journal of Pediatric Endocrinology and Metabolism

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“…Three studies have failed to find any association between vitamin D and insulin resistance in obese children [36,37,38]. Other studies report an inverse association between hypovitaminosis D and measures of insulin resistance and glycaemia in obese children [39,40,41]. Table 1 summarizes some of the recent studies that have investigated the association of 25(OH)D with glucose homeostasis in children.…”

Section: Link Between Vitamin D and Glucose Homeostasis -Evidence Fromentioning

confidence: 99%

Vitamin D and Its Effects on Glucose Homeostasis, Cardiovascular Function and Immune Function

et al. 2014

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In recent years there has been increasing interest in the non-skeletal effects of vitamin D. It has been suggested that vitamin D deficiency may influence the development of diabetes, cardiovascular dysfunction and autoimmune diseases. This review focuses on the current knowledge of the effects of vitamin D and its deficiency on cardiovascular function, glucose homeostasis and immune function, with a particular focus on children. Although, there is good evidence to show that there is an association between vitamin D deficiency and an abnormality of the above systems, there is little evidence to show that vitamin D supplementation leads to an improvement in function, especially in childhood.

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“…In adults, low 25-hydroxyvitamin [25(OH)D] concentration have been found to be associated with higher risk of hyperglycemia, insulin resistance, and type 2 diabetes [5] . In children, limited vitamin D data show an association with fasting hyperglycemia and insulin resistance [6,7] . Animal data show impaired insulin secretion during vitamin D deficiency [8] and an improvement in insulin secretion with vitamin D supplementation [9,10] .…”

Section: Introductionmentioning

confidence: 99%

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Tao

Zeng

et al. 2013

Acta Pharmacol Sin

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Aim: To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population. Methods: This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and β-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), respectively. Results: Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca 2+ and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001). Conclusion: Serum vitamin D level is significantly and independently associated with insulin resistance and β-cell function in a healthy Chinese female population.

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Vitamin D Insufficiency Is Associated With Diabetes Risk in Native American Children

Abstract: Vitamin D insufficiency was nearly universal in this cohort of NA children and was associated with diabetes and vascular risk markers. Whether vitamin D supplementation can improve insulin resistance must be studied further.

Cited by 31 publications

References 30 publications

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Vitamin D and Its Effects on Glucose Homeostasis, Cardiovascular Function and Immune Function

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

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