Vitamin D Insufficiency/Deficiency in Patients with Recurrent Benign Paroxysmal Positional Vertigo

Pecci, Raffaella; Mandalà, Marco; Marcari, Antonella; Bertolai, Roberto; Vannucchi, Paola; Santimone, Rossana; Bentivegna, Lisa A.; Giustino, Fabio Di; Mengucci, Arianna; Vanni, Simone; Pollastri, Federica; Giannoni, Beatrice

doi:10.5152/iao.2022.21269

Cited by 7 publications

(15 citation statements)

References 21 publications

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“…This evidence and the outcomes of some recent trials [ 17 , 18 , 19 , 20 , 41 ] and meta-analysis [ 22 , 42 ] support the therapeutic effectiveness of the correction of hypovitaminosis D in patients with recurrent BPPV.…”

Section: Discussionmentioning

confidence: 59%

“…In recent literature, serum 25 (OH) D levels were correlated with higher BPPV occurrence, although some Authors have provided controversial results [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, several studies suggested that calcium metabolism disorders related to vitamin D deficiency might affect otoconia homeostasis, increasing the BPPV recurrence and the incidence of complicated forms [ 12 , 13 , 14 , 15 , 16 , 17 ]. An increasing number of studies investigated the efficacy of 1,25-dihydroxyvitamin D (or vitamin D3) supplementation in reducing BPPV recurrence [ 13 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

et al. 2022

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Benign paroxysmal positional vertigo (BPPV) usually has a favorable course, although it is possible to observe BPPV with a high recurrence rate. Previous studies suggested that vitamin D deficiency might affect BPPV recurrences, and oxidative stress might play a complementary role in BPPV pathogenesis. This multicentric trial aimed to evaluate the effectiveness of oral nutritional supplementation with a compound of alpha-lipoic acid, Carnosine, and Zinc (LICA® (Difass International, Coriano (RN), Italy)), vitamins of group B and vitamin D in preventing BPPV recurrences. A total of 128 patients with high recurrence-BPPV were randomized in three arms: Arm 1 consisted of subjects with “insufficient” or “deficient” vitamin D blood levels, treated with daily oral supplementation of LICA®, vitamins of group B and vitamin D3 (800 UI), Arm 2 included BPPV subjects with “sufficient” vitamin D who did not receive any nutritional support, and Arm 3 included subjects with a “sufficient” serum concentration of vitamin D who received supplementation with a compound of LICA® and Curcumin. After six months of follow-up, a significant reduction of BPPV relapses compared to the baseline was found only in Arm 1 (−2.32, 95% CI: 3.41–1.62, p-value < 0.0001). Study results suggested that oral nutritional supplementation with vitamin D3 plus antioxidants can prevent relapses in patients suffering from high recurrence-BPPV.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

et al. 2022

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“…A total of 12 studies reported that compared with controls, patients with BPPV have lower average serum vitamin D levels 1 26–35. Seven studies found no significant difference between the serum vitamin D levels of BPPV patients and controls 36–42. Among cases and controls with osteoporosis and osteopenia, two studies2 43 found no significant difference between cases and controls, although osteoporosis was correlated with low serum vitamin D in BPPV patients 2.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…The relationship between BPPV recurrence and serum 25-hydroxyvitamin D was examined in 12 studies, with 9 studies reporting lower serum vitamin D levels in patients with recurrent BPPV compared with those experiencing an initial attack1 31 35–37 42 45 46 and 3 reporting no significant difference in vitamin D levels between the 2 groups 38 47 48. Three studies41 49 50 reported that vitamin D supplementation reduced the number of recurrent episodes of BPPV. Vitamin D supplementation was seen to improve the bone mineral density of BPPV patients in one study, however, the effects on BPPV recurrence were not reported 51…”

Section: Quality Assessmentmentioning

confidence: 99%

Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis

Wood,

Kluk,

BinKhamis

2024

BMJ Open

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ObjectivesThe objective of this study is to determine the relationship between serum vitamin D level and the risk of developing benign paroxysmal positional vertigo (BPPV) incidence and recurrence in countries in the Northern Hemisphere.DesignSystematic review and meta-analysis.Data sourcesPubMed, Scopus and Web of Science databases were searched for studies published between January 2000 and February 2023.Eligibility criteria for selecting studiesParticipants located in the Northern Hemisphere aged 18 or over with at least one episode of BPPV, serum 25-hydroxyvitamin D levels measured and reported, no comorbidities or history of vitamin D supplementation.Data extraction and synthesisData extraction and synthesis were performed by a single reviewer and checked by a second reviewer. Inclusion and exclusion criteria and risk of bias were assessed by two independent reviewers using the Newcastle Ottawa Tool for Cohort studies and Risk of Bias Assessment Tool for Nonrandomised Studies checklist for case–control studies. Meta-analysis was conducted using random effects models. Standard mean difference with a 95% CI was used to measure the relationship between vitamin D level and BPPV.ResultsThe 35 articles identified by the literature search reported data of 9843 individuals. 19 studies (7387 individuals) were included in the BPPV incidence meta-analysis while 7 studies (622 individuals) were included in the BPPV recurrence meta-analysis. Lower serum vitamin D levels were found in BPPV incidence compared with controls, but the relationship between vitamin D levels in recurrent BPPV compared with non-recurrent disease remained uncertain.ConclusionResults of this systematic review and meta-analysis demonstrated a negative correlation between serum vitamin D and BPPV incidence, while any relationship between serum vitamin D and BPPV recurrence remained uncertain. Risk of bias analysis revealed evidence of variable quality. There were insufficient data available to evaluate seasonal relationships between serum vitamin D and BPPV. Given the potential for this as a confounding factor, future research should aim to investigate this further.PROSPERO registration numberCRD42021271840.

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Evaluation of a questionnaire as a screening tool for benign paroxysmal position vertigo

Yan

Wang

et al. 2022

Eur Arch Otorhinolaryngol

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Vitamin D Insufficiency/Deficiency in Patients with Recurrent Benign Paroxysmal Positional Vertigo

Cited by 7 publications

References 21 publications

Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis

Evaluation of a questionnaire as a screening tool for benign paroxysmal position vertigo

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