Vitamin D Insufficiency

Rosen, Clifford J.

doi:10.1056/nejmcp1009570

Cited by 752 publications

(671 citation statements)

References 40 publications

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“…Vitamin D has long been recognised as a major regulator of calcium and phosphorus metabolism and thus has key roles in bone formation and resorption (6)(7)(8) . Low bone mineral density is a common manifestation in Crohn's disease (9,10) and guidelines regarding supplementation are well established (11) .…”

mentioning

confidence: 99%

Optimal vitamin D levels in Crohn's disease: a review

Raftery

O’Sullivan

2014

Proc. Nutr. Soc.

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Vitamin D deficiency is common among patients with Crohn's disease. Serum 25-hydroxyvitamin D (25(OH)D) is the best measure of an individual's vitamin D status and current cut-off ranges for sufficiency are debatable. Several factors contribute to vitamin D deficiency in Crohn's disease. These include inadequate exposure to sunlight, inadequate dietary intake, impaired conversion of vitamin D to its active metabolite, increased catabolism, increased excretion and genetic variants in vitamin D hydroxylation and transport. The effects of low 25(OH)D on outcomes other than bone health are understudied in Crohn's disease. The aim of the present review is to discuss the potential roles of vitamin D and the possible levels required to achieve them. Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention. The present literature appears to suggest that 25(OH)D concentrations of ≥75 nmol/l may be required for non-skeletal effects; however, further research on optimal levels is required.

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confidence: 99%

Optimal vitamin D levels in Crohn's disease: a review

Raftery

O’Sullivan

2014

Proc. Nutr. Soc.

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“…Calcitriol synthesis may also be modulated by vitamin D receptors on the cell surface; downregulation of these receptors may play an important role in regulating vitamin D activation [6]. Increased levels of PTH and hypophosphatemia stimulate expression of 1 a-hydroxylase, while Fibroblast Growth Factor 23 (FGF23) -secreted by osteocytes in the bone matrix-inhibits the expression of the enzyme and thus calcitriol synthesis [7].…”

Section: Vitamin D Metabolismmentioning

confidence: 99%

“…Blood levels of 25(OH)D reflect the total VitD derived from diet, sunlight exposure and adipose store [7]. Studies have reported varying prevalence rates of VitD deficiency in predialysis and dialysis patients ranging between 70 and 98% [23,27] and 51 and 100% [28,29], respectively.…”

Section: Chronic Kidney Diseasementioning

confidence: 99%

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Effect of nutritional vitamin D preparations on parathyroid hormone in patients with chronic kidney disease

et al. 2011

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“…Additionally, the authors of the IOM report noted concerns regarding potential adverse effects associated with vitamin D intakes exceeding 100 mg/d (4000 IU/d) (15) . Subsequent publications by the IOM panel members have expanded on some of these points (16)(17)(18)(19) . Given the divide between the IOM recommendations and mainstream trends, we undertook a systematic analysis of the comprehensiveness and balance of newspaper coverage of the IOM report.…”

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confidence: 99%

Critical assessment of high-circulation print newspaper coverage of the Institute of Medicine report Dietary Reference Intakes for Calcium and Vitamin D

Hatfield

Sweeney

Lau

et al. 2013

Public Health Nutr.

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Objective: To evaluate high-circulation US and Canadian newspaper coverage of the Institute of Medicine (IOM) report Dietary Reference Intakes for Calcium and Vitamin D and assess pre-report and post-report reporter-specific vitamin D-related coverage. Design: Two independent reviewers analysed the newspaper articles. The key report findings cited, proportion of sentences describing the IOM report and proportion of sentences describing critical viewpoints on the report were calculated. The content of articles written by reporters with a history of pre-report vitamin D-related articles was compared with that of articles written by reporters without such a history. Setting: Factiva and LexisNexis searches of the top thirty US and three Englishlanguage Canadian print newspapers, by circulation. Subjects: Articles on the IOM report published from 30 November to 21 December 2010 and previous vitamin D-related articles written by the same reporters. Results: Only ten articles met inclusion/exclusion criteria. Articles inconsistently cited the key findings in the IOM report. Reporters with a history of pre-report articles highlighting the benefits of vitamin D dedicated a greater proportion of sentences to viewpoints critical of the IOM report (P , 0?01). There was no significant difference between pre-report publication history and proportion of sentences focused on the IOM report. A borderline-significant difference (P 5 0?058) was observed between pre-report articles highlighting the benefits of vitamin D and the absence of reference to potential risks of vitamin D overconsumption. Conclusion: Our findings suggest that newspaper articles did not consistently or comprehensively report the IOM recommendations and that pre-report publication history of reporters was related to post-report article content.

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Vitamin D Insufficiency

Cited by 752 publications

References 40 publications

Optimal vitamin D levels in Crohn's disease: a review

Optimal vitamin D levels in Crohn's disease: a review

Effect of nutritional vitamin D preparations on parathyroid hormone in patients with chronic kidney disease

Critical assessment of high-circulation print newspaper coverage of the Institute of Medicine report Dietary Reference Intakes for Calcium and Vitamin D

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