Vitamin D–Induced Acute Pancreatitis

Toxic Dose of Vitamin D-Induced Hypercalcemia

“…The level of ionized calcium is increased in acidemia because of reduced calcium binding to albumin. 8 Thus, as the serum calcium levels of the patient with vitamin D toxicity were within normal limits in the case reported by Weissman et al, 1 remeasurement of ionized calcium is important to accurately determine whether toxic doses of vitamin D cause hypercalcemia.…”

“…To the Editor: Pneumocystis jiroveci pneumonia (PJP) is an important cause of morbidity and mortality in solid organ transplant recipients (SOTRs). 1 It is associated with exposure to other PJP patients, use of sirolimus and everolimus. 1 Primary prophylaxis prolongs survival in immunocompromised patients.…”

“…1 It is associated with exposure to other PJP patients, use of sirolimus and everolimus. 1 Primary prophylaxis prolongs survival in immunocompromised patients. 2 In the absence of prophylaxis, PJP incidence in SOTRs ranges from 6.8% to 88%.…”

“…3,4 In addition, iatrogenic overdose of vitamin D causes acute pancreatitis with hypercalcemia. 5,6 Weissman et al 1 described that vitamin D toxicity causes acute pancreatitis without hypercalcemia. However, in an endemic area of vitamin D deficiency, hypercalcemia was reported in 9 cases of vitamin D toxicity as a result of high-dose therapy.…”

Vitamin D and Pancreatitis: A Narrative Review of Current Evidence

“…A case report described a patient in whom recurrent attacks of pancreatitis were induced by vitamin D poisoning associated with hypercalcemia. Vitamin D-induced AP reportedly occurred in a patient with a history of vitamin D 3 supplementation and high levels of serum 1,25(OH) 2 D without other etiologies [ 65 ].…”