Vitamin D increases IGF-I and insulin levels in experimental diabetic rats

Derakhshanian, Hoda; Javanbakht, Mohammad Hassan; Zarei, Mahnaz; Djalali, Ehsan; Djalali, Mahmoud

doi:10.1016/j.ghir.2017.09.002

Cited by 37 publications

(34 citation statements)

References 29 publications

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“…Macro elements, vitamins, trace elements and organic acids are the four major classes of micronutrients. Macro elements primarily include chloride, calcium, phosphorous, magnesium, sodium, potassium and iron, whereas certain trace elements like cobalt, boron, chromium, copper, sulfur, iodine, zinc and molybdenum enhance insulin action by activating insulin receptor sites [ 14 ]. These trace elements play specific roles in the pathogenesis and progression of type 2 diabetes mellitus (T2DM) and the mode of action of a number of macro and trace elements is altered in T2DM [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

2020

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Minerals and trace elements are micronutrients that are essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies in these micronutrients are related to widespread human health problems. This review article is focused on some of these minerals and trace element deficiencies and their consequences in diabetes and insulin resistance. The levels of trace elements vary considerably among different populations, contingent on the composition of the diet. In several Asian countries, large proportions of the population are affected by a number of micronutrient deficiencies. Local differences in selenium, zinc, copper, iron, chromium and iodine in the diet occur in both developed and developing countries, largely due to malnutrition and dependence on indigenous nutrition. These overall deficiencies and, in a few cases, excess of essential trace elements may lead to imbalances in glucose homeostasis and insulin resistance. The most extensive problems affecting one billion people or more worldwide are associated with inadequate supply of a number of minerals and trace elements including iodine, selenium, zinc, calcium, chromium, cobalt, iron, boron and magnesium. This review comprises various randomized controlled trials, cohort and case-controlled studies, and observational and laboratory-based studies with substantial outcomes of micronutrient deficiencies on diabetes and insulin resistance in diverse racial inhabitants from parts of Asia, Africa, and North America. Changes in these micronutrient levels in the serum and urine of subjects may indicate the trajectory toward metabolic changes, oxidative stress and provide disease-relevant information.

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Section: Introductionmentioning

confidence: 99%

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

2020

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“…En este caso, estudios previos han postulado que la vitamina D 3 podría actuar incrementando los niveles de insulina y IGF-1 (11) regulando el proceso de degradación de la insulina y de la fosforilación del receptor de esta (12) . En el caso de los efectos de la vitamina D 2 , que representa la forma más comúnmente ingerida, pocos han sido los estudios que evalúen sus efectos en modelos experimentales, basados en ensayos clínicos (16,17) que han sugerido que su potencia y duración de acción serían menores que las obtenidas con el uso de vitamina D 3.…”

Section: Discussionunclassified

“…Los animales fueron distribuidos aleatoriamente en ocho grupos de seis ratas cada uno, basándonos en estudios previos (11) : un grupo control negativo (CN) al que se le administró 2 mL de suero fisiológico y una dieta balanceada; un grupo control positivo (CP) al que se le suministró 2 mL de suero fisiológico y una dieta modificada (colesterol 200 mg/kg y 1 mL de solución de fructuosa al 10%), y seis grupos experimentales: EXP1: dieta modificada y vitamina D 2 (10000 UI/kg); EXP2: dieta modificada y vitamina D 2 (35000 UI/kg); EXP3: dieta modificada y vitamina D 2 (70000 UI/kg); EXP4: dieta modificada y vitamina D 3 (10000 UI/kg); EXP5: dieta modificada y vitamina D 3 (35000 UI/kg); EXP6: dieta modificada y vitamina D 3 (70000 UI/kg).…”

Section: Modelo De Experimentaciónunclassified

“…Estudios previos en modelos animales han sugerido que la vitamina D podría promover directamente la estimulación de la expresión del receptor de insulina en las células β y mediar indirectamente en la regulación del calcio extracelular y el mantenimiento de la afluencia normal de calcio a estas células (11)(12)(13); sin embargo, los resultados sobre su eficacia como una alternativa terapéutica en estados hiperglicémicos aún son contradictorios y poco estudiados. Por ende, el objetivo del presente estudio es determinar el efecto de la vitamina D 2 y vitamina D 3 en el control de la glicemia en un modelo murino de inducción de hiperglicemia experimental.…”

Section: Introductionunclassified

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Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas

Jokada¹,

Arroyo-Acevedo²,

Chávez-Rimache³

et al. 2017

Rev. per. med. integr.

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Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas. Rev Peru Med Integrativa.2017;2(3):798-802. Historia del artículo Información del artículo ResumenObjetivo. Determinar el efecto del Ergocalciferol (vitamina D 2 ) y el colecalciferol (vitamina D 3 ) sobre el control de la glicemia en ratas. Materiales y métodos. Estudio experimental. Se utilizó 48 ratas machos Wistar de 12 semanas de edad, con un peso de 200 ± 50 g, distribuidas de manera aleatoria en ocho grupos de seis: control negativo (suero fisiológico a 2 mL/dieta balanceada); control positivo (suero fisiológico a 2 mL/dieta modificada); EXP 1 (vitamina D 2 a 10000 UI/kg /dieta modificada); EXP 2 (vitamina D 2 a 35000 UI/kg /dieta modificada); EXP 3 (vitamina D 2 a 70000 UI/kg /dieta modificada); EXP 4 (vitamina D 3 a 10000 UI/kg /dieta modificada); EXP 5 (vitamina D 3 a 35000 UI/kg /dieta modificada), y EXP 6 (vitamina D 3 a 70000 UI/kg /dieta modificada); se administraron dos tipos de dietas (dieta balanceada y dieta modificada a base de colesterol y fructuosa) y vitaminas D 2 y D 3 de manera conjunta durante las 13 semanas de estudio. Resultados. El promedio de glicemia del grupo control negativo (CN) fue 80,17 mg/dL; en los grupos experimentales fueron: 91,17 mg/dL (EXP1); 90,17 mg/dL (EXP2); 87,67 mg/dL (EXP3); 91,67 mg/dL (EXP4); 88,33 mg/dL (EXP5); 81,83 mg/dL (EXP6), y en el grupo control positivo (CP) fue 134,84 mg/dL. Conclusión. Los grupos con dieta modificada y que recibieron ergocalciferol (vitamina D 2 ) o colecalciferol (vitamina D 3 ) mostraron niveles menores de glicemia en comparación con los que no recibieron suplementación, no habiendo diferencias significativas entre la utilización de algún tipo de vitamina D o las dosis de 35000 y 70000 UI. Palabras clave: Ergocalciferoles; Hiperglicemia; Experimentación Animal (Fuente: DeCS). Effect of ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) on glycemic control in rats AbstractObjective. Determine the effect of Ergocalciferol (Vitamin D 2 ) and Cholecalciferol (Vitamin D 3 ) on glycemic control in rats. Materials and Methods. Experimental study. 48 male Wistar rats aged 12 weeks of age were used, which weighted 200 ± 50 g, distributed randomly into eight groups of 6 members each one: negative control (saline solution at 2 mL/ balanced diet), positive control (saline solution at 2 mL/modified diet), EXP 1 (Vitamin D 2 at 10000 IU/kg / modified diet), EXP 2 (vitamin D 2 at 35000 IU/kg / modified diet), EXP 3 (Vitamin D 2 at 70000 IU/kg / modified diet), EXP 4 (Vitamin D 3 at 10000 IU/kg / modified diet), EXP 5 (Vitamin D 3 at 35000 IU/kg / modified diet), EXP 6 (Vitamin D 3 at 70000 IU/kg / modified diet); two types of diets (balanced diet and modified diet based on cholesterol and fructose) and vitamins D 2 and D 3 were administered together during the 13 weeks of study. Results. The average of glycemia in the negative control group (NC) was 80.17 mg/dL; in the experimental groups were: 91.17 mg/dL (EXP1), 90.17 mg...

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“…Experimental studies have indicated the beneficial role of vitamin D in Type 1 Diabetes. Derakhshanian et al, have shown that vitamin D significantly improved fasting glucose, insulin, and IGF-1 in the type 1 diabetes (T1D) rat model [ 119 ]. Similarly, vitamin D treatment was shown to enhance the insulin secretion and to suppress the apoptosis of pancreatic β-cells in the T1D mice model [ 120 ].…”

Section: Molecular and Clinical Studies Of Vitamin D In Various Dimentioning

confidence: 99%

Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies

Umar

Sastry

Chouchane

2018

IJMS

188

151

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The classical function of Vitamin D, which involves mineral balance and skeletal maintenance, has been known for many years. With the discovery of vitamin D receptors in various tissues, several other biological functions of vitamin D are increasingly recognized and its role in many human diseases like cancer, diabetes, hypertension, cardiovascular, and autoimmune and dermatological diseases is being extensively explored. The non-classical function of vitamin D involves regulation of cellular proliferation, differentiation, apoptosis, and innate and adaptive immunity. In this review, we discuss and summarize the latest findings on the non-classical functions of vitamin D at the cellular/molecular level and its role in complex human diseases.

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Vitamin D increases IGF-I and insulin levels in experimental diabetic rats

Cited by 37 publications

References 29 publications

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas

Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies

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