Vitamin D inadequacy among post-menopausal women: a systematic review

Gaugris, Sabine; Heaney, Robert P.; Boonen, Steven; Kurth, Henriette; Bentkover, Judith D.; Sen, Shuvayu S.

doi:10.1093/qjmed/hci096

Cited by 166 publications

(123 citation statements)

References 54 publications

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“…High calcium levels may reflect different conditions in specific groups as pHPT and low vitamin-D-levels are more common in postmenopausal [15,17] and obese women [16]. It is possible to hypothesise that calcium levels in postmenopausal and obese women may reflect PTH levels rather than vitamin-D levels and that calcium levels in premenopausal women may mainly be a marker of vitamin-D levels.…”

Section: Discussionmentioning

confidence: 99%

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Serum calcium and breast cancer risk: results from a prospective cohort study of 7,847 women

Almquist

Manjer

Bondeson

et al. 2007

Cancer Causes Control

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Experimental and epidemiological studies suggest that calcium-regulating hormonesparathyroid hormone (PTH) and vitamin D -may be associated with breast cancer risk.No prospective cohort study has investigated the association between pre-diagnostic calcium levels and subsequent risk of breast cancer. We have examined this in a cohort of 7847 women where serum calcium levels and established risk factors for breast cancer had been assessed at baseline. During a mean follow-up of 17.8 years, 437 incident breast cancer cases were diagnosed. Incidence of breast cancer was calculated in different quartiles of serum calcium levels and a Cox's proportional hazards analysis was used to obtain corresponding relative risks (RR), with a 95% confidence interval (CI), adjusted for potential confounders.In premenopausal women, serum calcium levels were inversely associated with breast cancer risk in a dose-response manner. The adjusted RR (95% CI) of breast cancer was in the 2 nd calcium quartile 0.91 (0.65-1.30), in the 3 rd quartile 0.89 (0.60-1.31), and in the 4 th quartile 0. 56 (0.32-0.98), as compared to the 1 st calcium quartile. In postmenopausal overweight women (BMI>25), breast cancer risk was higher in calcium quartiles 2 to 4 as compared to the 1 st quartile. Our findings may have implications for primary prevention of breast cancer and for the management of asymptomatic primary hyperparathyroidism.

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Section: Discussionmentioning

confidence: 99%

“…High age and obesity are associated with a high prevalence of pHPT [15,16] and low levels of vitamin-D, e.g. 25(OH)D [17]. It has also been suggested that pre-and postmenopausal women may have different risk factors for breast cancer [18] and that obesity may modify the association between established risk factors and breast cancer [19].…”

Section: Introductionmentioning

confidence: 99%

Serum calcium and breast cancer risk: results from a prospective cohort study of 7,847 women

Almquist

Manjer

Bondeson

et al. 2007

Cancer Causes Control

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“…wearing long garments), the age, the skin pigmentation, along with a low VD dietary intake. [8][9][10] Long lactation periods, the use of skin sun blockers, the frequent use of umbrellas, 3,11,12 tobacco smoking, obesity and renal chronic disease have been also associated with VDD in women. 3,[11][12][13][14][15][16] It is not clear whether the VDD is produced by obesity or obesity is a consequence of VDD, 17 because obese individuals specially women, 18 are susceptible to VDD due to diminished availability of VD stored in the adipose tissue, and on the other hand, 18 some studies in obese individuals suggest that the supplementation with VD reduces the body fat mass.…”

Section: Vitamin D Status In Mexican Womenmentioning

confidence: 99%

Vitamin D status by sociodemographic factors and body mass index in Mexican women at reproductive age

Contreras‐Manzano¹,

Villalpando²,

Robledo-Pérez³

2017

Salud Publica Mex

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“…African Americans are more prone to be deficient because of higher skin melanin levels. 70 Vitamin D inadequacy constitutes a largely unrecognized epidemic in many populations worldwide [71][72][73] It has been reported in healthy children, 74 adolescents 75 and adults. 76,77 Vitamin D and prostate health Normal and malignant prostate cells contain VDRs, [78][79][80] which mediate the antiproliferative action of 1,25(OH)2D.…”

Section: Hypovitaminosis Dmentioning

confidence: 99%

Vitamin D and prostate cancer risk: a review of the epidemiological literature

Gupta

Lammersfeld

Trukova

et al. 2009

Prostate Cancer Prostatic Dis

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Prostate cancer is the most commonly diagnosed cancer in the United States. Prostate cells contain vitamin D receptors as well as enzymes necessary for vitamin D metabolism. Vitamin D metabolites have an antiproliferative and a pro-differentiating effect on prostate cancer cell lines in vitro and in vivo. As a result, there has been an emerging interest in the potential role of vitamin D in the etiology of prostate cancer. This review summarizes all available epidemiological literature on the association between dietary vitamin D, circulating levels of vitamin D and sunlight exposure in relation to prostate cancer risk. To place these studies in context, we also provide some background information on vitamin D, such as its dietary sources, metabolism, optimal levels, hypovitaminosis and relationship with the prostate.

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Vitamin D inadequacy among post-menopausal women: a systematic review

Cited by 166 publications

References 54 publications

Serum calcium and breast cancer risk: results from a prospective cohort study of 7,847 women

Serum calcium and breast cancer risk: results from a prospective cohort study of 7,847 women

Vitamin D status by sociodemographic factors and body mass index in Mexican women at reproductive age

Vitamin D and prostate cancer risk: a review of the epidemiological literature

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