Vitamin D in Treatment-Resistant CTS Patients with Hypovitaminosis D

Mohtashamkia, Marzieh; Roshanzamir, Sharareh; Saghanezhad, Seyed Mohammad

doi:10.7860/jcdr/2018/26417.11828

Cited by 5 publications

(19 citation statements)

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“…In this study, we documented a significant improvement in pain and functional outcomes in CTS patients with vitamin deficiency at 3 months posttreatment (vitamin D 3 supplementation along with initial standard treatment) compared with baseline as reflected by the changes in the VAS and Boston CTS questionnaire (SSS and FSS) score. The findings of our study are similar and in agreement with studies of Mohtashamkia et al 12 and Saçmaci et al, 24 and add to the literature supporting vitamin D supplementation, when deficient, in patients with CTS.…”

Section: Discussionsupporting

confidence: 93%

“…The study also documented that the mean nerve conduction velocity values improved from the baseline value of 27.02 ± 4.64 to 32.58 ± 4.54 after treatment. 12 Similarly, Saçmaci et al 24 in 50 female patients with mild and moderate CTS with vitamin D deficiency demonstrated that vitamin D 2 /D 3 (dose of 6000 IU/day or 50 000 IU/ week) treatment for 8 weeks followed by maintenance therapy resulted in significant improvement in pain and electrophysiological parameters after vitamin D replacement. In patients with mild CTS, the mean VAS score at baseline was significantly reduced from 6.64 ± 1.13 to 4.53 ± 0.69 after treatment (P < .001), whereas in moderate CTS, the mean VAS score at baseline also significantly reduced from 7.45 ± 0.69 to 6.64 ± 0.85 after treatment (P < .001).…”

Section: Discussionmentioning

confidence: 95%

“…11 Overall, the findings of beneficial outcomes with vitamin D 3 supplementation of this study substantiate to the work of earlier studies. 11,12,24 It also adds to the literature supporting vitamin D supplementation, when deficient, in patients with CTS.…”

Section: Discussionmentioning

confidence: 97%

“…2,8 Vitamin D deficiency is a recognized risk factor in the development of symptoms in CTS. 9,10 It has been suggested that vitamin D replacement may have a beneficial role in patients with CTS with hypovitaminosis D. 9,10 Studies have shown beneficial effects with vitamin D supplementation after carpal tunnel surgery and in refractory, treatment-resistant CTS with hypovitaminosis D. 11,12 There is limited evidence on the clinical outcome of vitamin D replacement therapy in CTS patients with vitamin D deficiency. Therefore, the purpose of this study was to evaluate the effects of vitamin D 3 supplementation on HAND 17 (6) functional and symptomatic outcomes in CTS patients with vitamin D deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown beneficial effects with vitamin D supplementation after carpal tunnel surgery and in refractory, treatment-resistant CTS with hypovitaminosis D. 11,12 There is limited evidence on the clinical outcome of vitamin D replacement therapy in CTS patients with vitamin D deficiency. Therefore, the purpose of this study was to evaluate the effects of vitamin D 3 supplementation on functional and symptomatic outcomes in CTS patients with vitamin D deficiency.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Functional and Symptomatic Outcomes After Vitamin D₃ Administration in Carpal Tunnel Syndrome With Hypovitaminosis D

Samant

Sane

2021

Hand (New York, N,Y.)

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Background Vitamin D deficiency is now recognized as an independent risk factor and is involved in the pathogenesis of carpal tunnel syndrome (CTS). The purpose of this study was to evaluate the effects of vitamin D3 supplementation on functional and symptomatic outcomes in CTS patients with vitamin D deficiency. Methods This was a prospective, single-arm study with a pretreatment or posttreatment quasi-experimental design. Carpal tunnel syndrome patients with vitamin D deficiency were treated with vitamin D3 (60 000 IU/week) plus standard treatment for a period of 3 months. Carpal tunnel syndrome–related pain and functional and symptomatic outcomes were assessed at baseline and at 3 months posttreatment using the Visual Analogue Scale (VAS) and the Boston Carpal Tunnel Questionnaire, respectively, along with serum vitamin D. Results A total of 42 patients were analyzed. At 3 months posttreatment, there was a significant reduction in the severity of pain (VAS score) from baseline ( Z = −5.71, P < .001). Similarly, the functional and symptomatic outcomes (Boston symptoms severity scale [SSS] and Boston functional status scale [FSS] score) at 3 months posttreatment significantly improved in comparison with baseline (Boston SSS: Z = −5.66, P < .001; Boston FSS: Z = −5.68, P < .001). Conclusions Vitamin D3 supplementation was associated with improvement in functional and symptomatic outcomes and CTS-related pain in CTS with vitamin deficiency. However, further robust randomized controlled trials are warranted to validate the results.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Functional and Symptomatic Outcomes After Vitamin D₃ Administration in Carpal Tunnel Syndrome With Hypovitaminosis D

Samant

Sane

2021

Hand (New York, N,Y.)

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The effects of vitamin D supplementation in carpal tunnel syndrome treatment outcomes: a systematic review

2021

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Purpose Vitamin D deficiency is related to carpal tunnel syndrome symptoms. Correcting vitamin D levels by supplementation was supposed to improve carpel tunnel symptoms, though there is a lack of aggregated data about treatment outcomes. This study aimed to examine whether vitamin D supplementation could improve the treatment outcomes in carpal tunnel syndrome patients. Methods A comprehensive search of the PubMed, Cochrane Library, Scopus, and Web of Science databases for articles on vitamin D and carpel tunnel syndrome from January 2000 to March 2021 was performed. The article screening and data extraction were performed by two investigators independently with blinding to decisions on selected studies. All included studies had assessed the quality of evidence using the Methodological Index for Non-Randomized Studies (MINORS) scoring system. Results We retrieved four studies that met the eligibility criteria. The treatment outcomes were evaluated by visual analog scale (124 wrists), functional scores (176 patients), muscle strength (84 patients), and nerve conduction velocity (216 wrists). After vitamin D supplementation, two studies reported improved pain scores and nerve conduction velocity, and three studies showed enhancement of functional status. Conclusion Vitamin D administration could offer favorable outcomes in pain improvement, better functional status, and increased sensory conduction velocity in carpal tunnel syndrome. However, there is to date no recommendations concerning a standardized dose or duration of vitamin D administration in carpal tunnel syndrome; prescribing vitamin D at the usual appropriate dose is suggested as an additional treatment in patients with mild to moderate carpel tunnel symptoms. Level of Evidence Level IV, therapeutic study

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The Role of Vitamin D in Carpal Tunnel Syndrome Risk and Supplementation Outcomes: A Systematic Review

Heidari-Soureshjani

Savadjani

Sherwin

et al. 2023

CRR

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Background: Carpal tunnel syndrome (CTS) is a debilitating neuropathy that accompanies pain and other physical limitations and disrupts the normal functioning of the victims' lives. Objective: We aimed to investigate Vitamin D's preventive and therapeutic effects on the occurrence and remission of CTS symptoms. Methods: In this systematic review the PRISMA statement has been designed primarily. An extensive search was undertaken in various databases, including PubMed, Cochrane library, Web of Science, EMBASE, and Scopus. After considering the inclusion and exclusion criteria of the study, finally, 19 articles were retrieved. The raw data were extracted and entered into an Excel form, and the study outcomes were investigated. Conclusion: Vitamin D supplementation can improve the symptoms in CTS patients, and low serum 25(OH)D can aggravate the symptoms of the disease and could be a risk factor for its occurrence. However, more observational studies and clinical trials are needed.

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Vitamin D in Treatment-Resistant CTS Patients with Hypovitaminosis D

Cited by 5 publications

References 0 publications

Evaluation of Functional and Symptomatic Outcomes After Vitamin D₃ Administration in Carpal Tunnel Syndrome With Hypovitaminosis D

Evaluation of Functional and Symptomatic Outcomes After Vitamin D₃ Administration in Carpal Tunnel Syndrome With Hypovitaminosis D

The effects of vitamin D supplementation in carpal tunnel syndrome treatment outcomes: a systematic review

The Role of Vitamin D in Carpal Tunnel Syndrome Risk and Supplementation Outcomes: A Systematic Review

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Vitamin D in Treatment-Resistant CTS Patients with Hypovitaminosis D

Cited by 5 publications

References 0 publications

Evaluation of Functional and Symptomatic Outcomes After Vitamin D3 Administration in Carpal Tunnel Syndrome With Hypovitaminosis D

Evaluation of Functional and Symptomatic Outcomes After Vitamin D3 Administration in Carpal Tunnel Syndrome With Hypovitaminosis D

The effects of vitamin D supplementation in carpal tunnel syndrome treatment outcomes: a systematic review

The Role of Vitamin D in Carpal Tunnel Syndrome Risk and Supplementation Outcomes: A Systematic Review

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Product

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Evaluation of Functional and Symptomatic Outcomes After Vitamin D₃ Administration in Carpal Tunnel Syndrome With Hypovitaminosis D

Evaluation of Functional and Symptomatic Outcomes After Vitamin D₃ Administration in Carpal Tunnel Syndrome With Hypovitaminosis D