Vitamin D in the Treatment of Acne

Simpson, Charles A.; Ellis, Francis A.; Kirby-Smith, Hayden

doi:10.1001/archderm.1940.01490110021003

Cited by 4 publications

(1 citation statement)

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“…32 The endocrine effects of vitamin D mainly influence serum calcium homeostasis, but it has recently been discovered that it is essential for the proper function of nearly every tissue in the body including the brain, heart, muscles, immune system, and skin. The relationship between vitamin D and acne has long been theorised: Simpson et al 33 reported the effect of vitamin D in the treatment of acne vulgaris in 1940. In a more recent study, Agak et al 34 reported that P. acnes is a potent inducer of Th17 cells, and 1,25(OH)2D inhibits P. acnes-induced Th17 cell differentiation, which can be an effective option for modulating acne.…”

Section: Vitaminosis and Acnementioning

confidence: 99%

Acne and Systemic Diseases

2015

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Acne is a very common, multifactorial, complex, and chronic disease of the pilosebaceous unit that affects approximately 85% of adolescent patients and 3% of adult patients. The roles of sebaceous glands, androgens, follicular epithelial cells, Propionibacterium acnes , immune mediators, environmental factors, and genetic factors are well known in acne pathogenesis. Although it is not a life-threatening disease, it is closely associated with low quality of life and psychological depression. Moreover, acne can also be associated with hypovitaminosis, or may present as a part of systemic syndromes such as: congenital adrenal hyperplasia; seborrhoea-acne-hirsutism-androgenetic alopecia syndrome; polycystic ovary syndrome; hyperandrogenaemia, insulin resistance, and acanthosis nigricans syndrome; Apert syndrome; synovitis-acne-pustulosis-hyperostosis-osteitis syndrome; pyogenic arthritis, pyoderma gangrenosum, and acne syndrome; metabolic syndromes; and Behçet’s syndrome. These syndromes must be excluded in patients with severe and recalcitrant acne.

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Section: Vitaminosis and Acnementioning

confidence: 99%