Vitamin D in schizophrenia, major depression and alcoholism

Schneider, Bernhard; Weber, Bernhard; Frensch, A.; Stein, Jürgen M.; Fritze, Jürgen

doi:10.1007/s007020070063

Cited by 133 publications

(116 citation statements)

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“…However, there is evidence to suggest that vitamin D among people with psychosis is correlated with the season of blood sampling (Belzeaux et al, 2015;Berg et al, 2010;Crews et al, 2013;Grønli et al, 2014;Lally et al, 2016;Zhu et al, 2015) and parathyroid hormone levels (Bergemann et al, 2008;Rey-Sánchez et al, 2009;Schneider et al, 2000), the latter being negatively correlated to vitamin D. What this review highlights are a multitude of variables that have been found to not significantly correlate with vitamin D within the patient population including but not limited to: BMI, age, gender, smoking, duration of illness and GAF score.…”

Section: Discussionmentioning

confidence: 99%

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Adamson

Lally

Gaughran

et al. 2017

Psychiatry Research

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(199/ 200)People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1,770 psychosis, n= 8,171 controls) a mean difference in vitamin D levels between both groups of -11.14 ng/ml 0.59 was found.

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Section: Discussionmentioning

confidence: 99%

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Adamson

Lally

Gaughran

et al. 2017

Psychiatry Research

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“…Itzhaky et al 17 found in their study that hypovitaminosis D is more prominent in schizophrenic patients compared to patients with depression. Moreover, in the meta-analysis of Belvederi Murri et al 28 and in the study of Schneider et al 13 , it was found that 25(OH)D levels between these two disorders were similar. The cause of this contradiction could be attributed to the small number of samples included in the study, and to the fact that vitamin D was considered deficient at different values, and to the existing geographic and cultural variability of the patients included.…”

Section: Cmjmentioning

confidence: 93%

“…Majority of the studies in this field investigate vitamin D deficiency without focusing on the psychiatric diagnosis of psychiatric inpatients 5,10,11 . A limited number of studies attempted to compare vitamin D levels among psychiatric diagnoses 12,13 . However, such studies, relying on very small samples, offer conflicting results about the psychiatric disorder where vitamin D deficiency is prevalent.…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D according to psychiatric diagnosis groups: A study with control group

Mert¹

2016

Cumhuriyet Med J

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SUMMARYObjective: One of the risk factor for different psychiatric disorders has been indicated as hypovitaminosis D. The present study aimed to compare 25 (OH) D level between 4 different types of psychiatric disorders (schizophrenia, bipolar disorder, depression and anxiety disorder) and healthy controls, and to assess the risk factors of hypovitaminosis D in psychiatric inpatients. Method: This retrospective study included 974 individuals [depression (n=553), bipolar disorder (n=135), schizophrenia (n=186) and anxiety disorder (n=100)] who received inpatient treatment in psychiatry clinic between 2012 and 2014, and 574 individuals in control group who were not diagnosed with a psychiatric condition. A 25 (OH) D level less than 21 ng/mL was considered to indicate hypovitaminosis D. Results: 25 (OH) D level average of the control group was found to be significantly higher than that of the four psychiatric diagnosis groups (p<0.05). There was no significant difference among 25 (OH) D level of psychiatric diagnosis groups (p<0.05). Comparing 25 (OH) D level among age groups in each study group, it was found that 25 (OH) D level of schizophrenic patients with an age range of 35-54 was found to be significantly lower than that of schizophrenic patients with an age range of 18-34 (p<0.05). 25 (OH) D levels by genders were lower among women in all diagnosis groups (p<0.05), while they were similar for both genders in control group (p>0.05). Logistic regression analysis of the study parameters suggested that the female gender (odds ratio: 3.46; 95% confidence interval: 0.99-1.01), winter and spring seasons (odds ratio: 2.56; 95% confidence interval: 1.69-3.86 and odds ratio: 2.03; 95% confidence interval: 1.33-3.11, respectively) were significant predictors in level of vitamin D in psychiatric inpatients. Conclusions: Hypovitaminosis D is a condition that frequently exists in inpatients in psychiatry clinic suffering from schizophrenia, bipolar disorder, anxiety disorder and d epression. Being a female, winter and spring are the most remarkable risk factors in these patients. Keywords: Hypovitaminosis D, schizophrenia, bipolar disorder, depression, anxiety Sonuç: Psikiyatri kliniğinde yatarak tedavi gören şizofreni, bipolar bozukluk, anksiyete ve depresyon hastalarında vitamin D eksikliği sıklıkla görülen bir durumdur. Bu hastalarda kadın olma ve kış-ilkbahar mevsimleri vitamin D eksikliği için en önemli risk faktörleri olarak belirlenmiştir.

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“…Some studies have demonstrated that 25 (OH) D which is thought to be a more reliable marker in the determination of vitamin D levels, is at a lower concen-tration in depressive patients relative to healthy controls (Eskandari et al 2007, Hoogendijk et al 2008, Jorde et al 2006, Schneider et al 2000. However some other studies do not support these finding (Herrán et al 2000, Pan et al 2009).…”

Section: Introductionmentioning

confidence: 99%