Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

Gannagé‐Yared, Marie‐Hélène; Chedid, Rima; Khalife, Simon; Azzi, Emmanuel; Zoghbi, F.; Halaby, Georges

doi:10.1530/eje-08-0952

Cited by 160 publications

(151 citation statements)

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“…In the present study, participants with MetS had significantly lower 25(OH)D levels than participants without MetS. The inverse relationship between serum 25(OH)D and FBG was reported in other studies, too (20,21,26,28,60) . However, in a study by Ashraf et al on obese African-American adolescent females, no relationship was found between serum 25(OH)D and FBG (23) .…”

Section: Discussionsupporting

confidence: 82%

Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran

Rafraf

Hasanabad

Jafarabadi

2013

Public Health Nutr.

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Objective: To investigate vitamin D status and its association with components of the metabolic syndrome (MetS) in adolescent girls attending high school in Boukan, Iran during winter 2012. Design: A cross-sectional study. Setting: High schools of Boukan city, Iran. Subjects: A sample of 216 girls aged 14-17 years was selected by multistage random sampling from four districts of Boukan. Weight, height, waist circumference, blood pressure, daily energy intake, physical activity and serum 25-hydroxyvitamin D (25(OH)D), fasting blood glucose, TAG and HDL-cholesterol levels of all participants were evaluated. Serum 25(OH)D level ,20 ng/ml was defined as vitamin D deficiency. Results: Mean serum 25(OH)D was 7?26 (SD 2?81) ng/ml and 96 % of the participants had vitamin D deficiency. According to age-modified definitions of the National Cholesterol Education Program Adult Treatment Panel III, MetS was diagnosed in 10?6 % of the participants. In multivariable regression analysis after adjustment for BMI, energy intake and physical activity level, serum 25(OH)D was inversely associated with fasting blood glucose (b 5 20?143, P 5 0?04). No significant relationship was found between serum 25(OH)D and other components of MetS. Conclusions: The high prevalence of vitamin D deficiency warrants national polices and interventions towards improving this major health problem among adolescent girls. Low 25(OH)D level was significantly associated with increased fasting blood glucose. Prospective studies are needed to determine the effects of vitamin D deficiency on the development of MetS and related metabolic diseases in adolescent girls. Keywords Vitamin D Prevalence Metabolic syndrome Adolescent girlsVitamin D deficiency is a major public health problem and an unrecognizable condition of epidemic proportions in both developed and developing countries, with widespread reports of 30-93 % prevalence in children and adults (1)(2)(3) . Determination of vitamin D status in different age groups in a community and in different climates of a country is necessary and has important implications for general health. Recent studies suggest that vitamin D deficiency is no longer just a problem of the older generations but also is an important health concern among younger generations (4) . Studies in the last two decades have shown a high prevalence of vitamin D deficiency in healthy adolescents in different countries (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) . In Iran, Razzaghy-Azar and Shakiba and Moussavi et al. reported that 67 % of female children and adolescents in Tehran and 72?1 % of teenage girls in Isfahan had vitamin D deficiency, with higher rates of deficiency in girls than boys (16,17) . Vitamin D is known as the 'sunshine vitamin' because the mean exposure to sunlight should be sufficient for most people to produce their own vitamin D using UV light and cholesterol in the skin (18) . Whenever sun exposure is insufficient, dietary intake of this vitamin becomes a necessity. However, there are few dietary sources of vitamin D...

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Section: Discussionsupporting

confidence: 82%

Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran

Rafraf

Hasanabad

Jafarabadi

2013

Public Health Nutr.

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“…However, in both the studies subjects with high serum 25(OH)D concentrations tended to have higher HDL-C concentrations than those with lower serum 25(OH)D concentrations. Conversely, in a study on 201 men and 180 women, Gannagé-Yared et al (2009) found no significant association between serum 25(OH)D and TAG, whereas in men there was a significant negative relation with serum LDL-C. A negative relation between serum 25(OH)D and both TC and LDL-C was also reported by Chiu et al (2004) in a study on 126 subjects, whereas in that study no association between serum 25(OH)D and TAG was found. And finally, no significant association between fasting serum lipids and serum 25(OH)D was found in 524 subjects in the MRC-Ely study (Forouhi et al, 2008).…”

Section: Discussionmentioning

confidence: 76%

“…However, the relation between serum 25(OH)D and serum lipids, which are among the major risk factors for cardiovascular disease (Kannel et al, 1971), is more uncertain (Ford et al, 2005;John et al, 2005;Martins et al, 2007;Forouhi et al, 2008;Hyppönen et al, 2008;Gannagé-Yared et al, 2009;Lee et al, 2009). We have therefore examined the cross-sectional relation between serum 25(OH)D and serum lipids in 12 000 subjects from the Tromsø study, and also examined the longitudinal relation between change in serum 25(OH)D concentrations and change in serum lipids over a 14 years period.…”

Section: Introductionmentioning

confidence: 99%

High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile

et al. 2010

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Background/Objectives: Low serum 25-hydroxyvitamin D (25(OH)D) concentrations are related to increased mortality. One possible explanation could be an association between serum 25(OH)D and serum lipids. Subjects/Methods: The study was performed at the University of Tromsø, Northern Norway. In total, 8018 nonsmoking and 2087 smoking subjects were included in a cross-sectional study performed in 2008, and 1762 nonsmoking and 397 smoking subjects in a longitudinal study from 1994/1995 to 2008. Nonfasting serum 25(OH)D, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio and triacylglycerol (TAG) were measured. Results: After adjustment for gender, age, sample month and body mass index in the cross-sectional study, there was a significant increase in serum TC, HDL-C and LDL-C, and a significant decrease in serum LDL-C/HDL-C ratio and TAG across increasing serum 25(OH)D quartiles. For serum HDL-C and TAG in nonsmokers the differences between the means for the highest and lowest serum 25(OH)D quartiles were 6.0 and 18.5%, respectively. In the longitudinal study, an increase in serum 25(OH)D was associated with a significant decrease in serum TAG. Conclusions: There is a cross-sectional association between serum 25(OH)D and serum lipids, and a longitudinal association over 14 years between serum 25(OH)D and TAG, which may contribute to explain the relation between low serum 25(OH)D concentrations and mortality.

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“…Parathyroid hormone (PTH), which increases in the presence of vitamin D insufficiency, was also linked to serum lipids (9) . However, the results are inconsistent and associations often vanished after controlling for confounding variables (5,6,8) .The question arises whether the assumed associations between serum lipids and vitamin D and PTH are independent from other cardiovascular risk factors like obesity, which has been associated with elevated serum lipids (10) and may also interfere with the vitamin D endocrine system (11) . In addition, the associations may differ by sex considering the differences in body composition and serum lipid levels between women and men.…”

mentioning

confidence: 99%

“…In addition, the associations may differ by sex considering the differences in body composition and serum lipid levels between women and men. Previous studies were mostly performed on ambulatory patients and/or vitamin Ddeficient, middle-aged or overweight and obese individuals and often without adjustments for potential confounders, such as the association between vitamin D and PTH, body composition, medical conditions and/or lifestyle factors, including sun exposure, physical activity and habitual diet (4)(5)(6)(7)9,(12)(13)(14)(15) .…”

mentioning

confidence: 99%

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

Jungert

Roth²,

Neuhäuser‐Berthold

2014

Public Health Nutr.

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Objective: Although emerging evidence indicates an association between vitamin D and serum lipids, the data are still inconsistent. The purpose of the present study was to investigate whether 25-hydroxycholecalciferol (25-hydroxyvitamin D 3 ; 25(OH)D 3 ) or intact parathyroid hormone (iPTH) was independently related to serum lipids in elderly women and men. Design: Cross-sectional study. Fasting serum levels of 25(OH)D 3 , iPTH, TAG, total cholesterol (TC), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) were assessed. Body composition was measured by bioelectrical impedance analysis. Lifestyle factors, such as nutrient intake, time spent outdoors, physical activity, smoking, supplement intake and medication, were assessed by questionnaires. Multiple regression analyses were performed to examine associations of 25(OH)D 3 and iPTH with serum lipids. Setting: Giessen, Germany. 25-Hydroxycholecaliferol Parathyroid hormone Serum lipids ElderlyAccumulating epidemiological data indicate that vitamin D deficiency may be accompanied by susceptibility for chronic diseases (1) . Recently, a low vitamin D status has been linked to increased serum levels of TAG, total cholesterol (TC) and LDL cholesterol (LDL-C), as well as low concentrations of HDL cholesterol (HDL-C) (2)(3)(4)(5)(6)(7)(8) . Parathyroid hormone (PTH), which increases in the presence of vitamin D insufficiency, was also linked to serum lipids (9) . However, the results are inconsistent and associations often vanished after controlling for confounding variables (5,6,8) .The question arises whether the assumed associations between serum lipids and vitamin D and PTH are independent from other cardiovascular risk factors like obesity, which has been associated with elevated serum lipids (10) and may also interfere with the vitamin D endocrine system (11) . In addition, the associations may differ by sex considering the differences in body composition and serum lipid levels between women and men. Previous studies were mostly performed on ambulatory patients and/or vitamin Ddeficient, middle-aged or overweight and obese individuals and often without adjustments for potential confounders, such as the association between vitamin D and PTH, body composition, medical conditions and/or lifestyle factors, including sun exposure, physical activity and habitual diet (4)(5)(6)(7)9,(12)(13)(14)(15) .As dyslipidaemia is an important CVD risk factor and an established component of the metabolic syndrome, treatment and prevention strategies are of particular importance (16) . This applies especially to elderly people, who are at risk of developing dyslipidaemia. Moreover, an advanced age is linked to vitamin D deficiency because of age-related declines in endogenous vitamin D synthesis, sun exposure

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Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

Cited by 160 publications

References 39 publications

Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran

Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran

High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

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