Vitamin D in Nature: A Product of Synthesis and/or Degradation of Cell Membrane Components

Göring, Harald H.H.

doi:10.1134/s0006297918110056

Cited by 31 publications

(22 citation statements)

References 70 publications

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“…First, none of the included studies described the methods of collection or duration of preservation of collected serum before 25(OH)D assay. The effects of light, temperature, collection tube properties, and longterm serum storage on assay results are uncertain, particularly with respect to 25(OH)D stability [40]. Second, the methods for determining the concentration of 25(OH)D among the studies were different.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

et al. 2019

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Background: We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). Methods: We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package. Results: Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10-20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml). Conclusion: There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10-20 ng/ml).

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

et al. 2019

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“…It has been speculated that the vitamin D: provitamin D ratio might be a proxy of UV-B assimilation in plants [ 20 ]. In microalgae, vitamin D production might be the result of damage or degradation of biological membranes under the action of UV radiation [ 21 , 22 ].…”

Section: Functions and Roles Of Vitamins In Microalgaementioning

confidence: 99%

“…Conversely, vitamin D concentration was very low (0.004 µg/g DW) in other species, such as Rhodomonas salina , Arthrospira maxima or Chlorella minutissima (Table 5 ). Also, ergosterol, precursor of vitamin D 2 , was found in various species of microalgae, e.g., Dunaliella tertiolecta [ 98 ], Chlamydomonas reinhardtii [ 35 , 99 ], Chlorella vulgaris [ 37 ], Cyanidium caldarium [ 38 ] and account up to 0.1% of the dry weight in the coccolitophore Emiliania huxleyi [ 21 ].…”

Section: Content and Modulation Of Vitamins In Microalgaementioning

confidence: 99%

Challenging microalgal vitamins for human health

et al. 2020

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Background Vitamins’ deficiency in humans is an important threat worldwide and requires solutions. In the concept of natural biofactory for bioactive compounds production, microalgae represent one of the most promising targets filling many biotechnological applications, and allowing the development of an eco-sustainable production of natural bioactive metabolites. Vitamins are probably one of the cutting edges of microalgal diversity compounds. Main text Microalgae can usefully provide many of the required vitamins in humans, more than terrestrial plants, for instance. Indeed, vitamins D and K, little present in many plants or fruits, are instead available from microalgae. The same occurs for some vitamins B (B12, B9, B6), while the other vitamins (A, C, D, E) are also provided by microalgae. This large panel of vitamins diversity in microalgal cells represents an exploitable platform in order to use them as natural vitamins’ producers for human consumption. This study aims to provide an integrative overview on vitamins content in the microalgal realm, and discuss on the great potential of microalgae as sources of different forms of vitamins to be included as functional ingredients in food or nutraceuticals for the human health. We report on the biological roles of vitamins in microalgae, the current knowledge on their modulation by environmental or biological forcing and on the biological activity of the different vitamins in human metabolism and health protection. Conclusion Finally, we critically discuss the challenges for promoting microalgae as a relevant source of vitamins, further enhancing the interests of microalgal “biofactory” for biotechnological applications, such as in nutraceuticals or cosmeceuticals.

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“…, is measured in humans to assess overall vitamin D status (for reviews, see Bouillon (4) and Göring (9) ).…”

Section: -Hydroxyvitamin D (25(oh)d)mentioning

confidence: 99%

The Eurasian lactase persistence variant LCT-13910 C/T is associated with vitamin D levels in individuals living at high latitude, more so than exposure to sunlight

Moghaddam

2020

J Nutr Sci

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Rapid selection of a genetic variant that confers continuous life-long lactase production in Europeans (LCT-13910 C/T) has been attributed to the advantages of acquiring nutrients from consuming milk without the disadvantages of lactose malabsorption. Individuals with this genetic lactase persistence (LP) variant generally consume more milk and have been shown to have higher levels of serum vitamin D. Vitamin D is the principal regulator of Ca absorption and its synthesis in skin is dependent on UVB exposure. The primary aim of the present study was to compare serum vitamin D concentrations with LP variant and to control for UVB exposure. Data from over 100 000 individuals living in Norway, a country with low UVB exposure, was retrospectively retrieved for comparison of genetic LP variant, serum 25-hydroxyvitamin D (25(OH)D) concentration and the time of year when serum samples were taken. For comparison, a similar analysis was performed with a natural dairy micronutrient, namely vitamin B12. It was found that individuals with the genetic LP variant had considerably higher levels of serum 25(OH)D (P < 2 × 10−16, Cohen's d = 0·73) but lower levels of vitamin B12 (P < 2 × 10−16, Cohen's d = 0·11), compared with genetic lactase non-persistent individuals, even when controlled for seasonality, age and sex. The difference in serum 25(OH)D levels did not diminish in summer months, showing the role of vitamin D in LP variant selection in areas of low UVB irradiation. LP variant selection advantage through acquiring another dairy micronutrient, vitamin B12, was not observed.

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Vitamin D in Nature: A Product of Synthesis and/or Degradation of Cell Membrane Components

Cited by 31 publications

References 70 publications

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

Challenging microalgal vitamins for human health

The Eurasian lactase persistence variant LCT-13910 C/T is associated with vitamin D levels in individuals living at high latitude, more so than exposure to sunlight

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