Vitamin D in migraine headache: a comprehensive review on literature

Ghorbani, Zeinab; Togha, Mansoureh; Rafiee, Pegah; Ahmadi, Zeinab; Magham, Reyhaneh Rasekh; Haghighi, Samaneh; Jahromi, Soodeh Razeghi; Mahmoudi, Maryam

doi:10.1007/s10072-019-04021-z

Cited by 48 publications

(60 citation statements)

References 122 publications

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“…Due to the existence of the majority of TNF-α receptors in trigeminal ganglion neurons, TNF-α, may increase CGRP gene expression in trigeminal ganglion neurons by increasing intra cellular MAP kinases signaling pathways, which might be attributed to the onset of headache (42)(43)(44)(45)(46). Additionally, NO can causes intense pain by increasing dilation and in ammation in cranial vessels through NO-cGMP pathway (9,10). Therefore, acidosis condition by augmenting in ammation and NO synthesis may have a negative effect on the initiation of migraine attacks.…”

Section: Discussionmentioning

confidence: 99%

“…These agents are associated with in ammation and vasodilation in cranial vessels, which lead to intense pain (5,6,8). NO is believed to play an important role in initiating of migraine attacks that perform its functions by NO/cyclic guanosine monophosphate (cGMP) pathway, and its levels are shown to be elevated in people with migraine during and between headache attacks (9,10). Moreover, cytokines and in ammatory agents around nerves can activate trigeminovascular neurons and increase CGRP release (11).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, cytokines and in ammatory agents around nerves can activate trigeminovascular neurons and increase CGRP release (11). It has been shown that in ammatory factors such as tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), Interleukin 6 (IL6) increased in people with migraine headache compared to healthy subjects (10,(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…High acidic load in the human body could affect in ammation, NO pathways, blood ow and adiposity measures (16)(17)(18)(19)(20). On the other hand, these factors are thought to play a role in initiation of migraine attacks (5,6,8,10,(12)(13)(14)(15). Thus, it can be hypothesized that higher consumption of acidogenic foods including meat that yield higher dietary acid load might increase the odds of developing migraine in susceptible patients.…”

Section: Introductionmentioning

confidence: 99%

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The association between dietary acid load and the migraine odds

Mousavi

Jahromi

Togha

et al. 2020

Preprint

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Background: According to previous evidence, it has been shown that high acidic load in human body could affect inflammatory factors and the nitric oxide pathway. On the other hand, these factors are thought to play a role in initiation of migraine attacks. Therefore, we aimed to explore the association between dietary acid load and the odds of migraine in a case-control study.Methods: The migraine group (n=514, diagnosed according to the ICHDIII criteria) was recruited from a tertiary headache clinic. The controls consisted of 582 sex-matched healthy volunteers who were randomly selected from the general population. For dietary intake assessments, we used a validated 168-item semiquantitative food frequency questionnaire (FFQ). Using three different measures, such as potential renal acid load (PRAL), net endogenous acid production (NEAP), and protein /potassium ratio for estimation of the dietary acid load.Results: According to multivariable logistic regression analysis, in comparison with the lowest tertile, highest tertile of dietary acid load measures including PRAL (OR=7.208, 95% CI 3.33– 15.55), NEAP (OR=4.108, 95% CI 1.924– 8.774), protein/potassium ratio (OR=4.127, 95% CI 1.933– 8.814) were shown to significantly increase odds of migraine (P for trend= <0.001).Conclusions: In this study, it was found that high dietary acid load may be associated with higher odds of migraine. Consequently, restricting dietary acid load could be beneficial in reducing the odds of developing migraine in susceptible subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The association between dietary acid load and the migraine odds

Mousavi

Jahromi

Togha

et al. 2020

Preprint

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“…Some clinical evidence demonstrated a direct relationship between low levels of vitamin D and headache (28). Furthermore, vitamin D regulates production and release of pro-inflammatory cytokines and higher vitamin D concentration is associated with lower frequency of monthly migraine headache (29,30).…”

mentioning

confidence: 99%

Does Atorvastatin Help Prevent Classic Migraine Attacks? A Triple-Blind Controlled Clinical Trial

Ganji¹,

Majdinasab²,

Hesam³

et al. 2020

Preprint

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Background: Migraine is a painful and disabling nervous disorder which negatively affects the quality of life. Migraineurs may suffer from a generalized vasomotor dysfunction. Statins improve vasomotor and vascular function, with their pleiotropic effects. We aimed to assess efficacy and safety of adding Atorvastatin to prophylactic regimen in better control of classic migraine.Methods: This triple-blind controlled clinical trial was on 68 consecutive patients with history of classic migraine. An interval of at least one month was given to evaluate vitamin D3 level and eligibility. In patients with vitamin D3 deficiency, the correction was provided by administration of soft gelatin capsule of vitamin D supplementation. The patients were randomly assigned to receive atorvastatin 20mg plus sodium valproate 500mg or placebo plus sodium valproate 500mg once a day for two months. The patients were evaluated based for the number of attacks and pain severity based on Visual Analogue Scale. Results: There was a significant (p = 0.0001) improvement in severity of pain and number of migraine attacks by adding Atorvastin to the prophylactic regimen of patients. After controlling for variable parameters, the differences between two arms of the study was yet statistically significant (p = 0.0001). A significant number of participants in intervention group were satisfied by their treatment (p = 0.001). There was no remarkable difference in two arms of the study in terms of possible side effects (P =0.315).Conclusions: The results of present study suggested that adding atorvastatin to migraine preventive regimen may help reduce the number of acute attacks and pain severity. This modality did not cause considerable side effects and led to a better patient satisfaction.

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Best Practice London: focus on lipid and migraine management

Titmarsh¹

2023

Prescriber

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Vitamin D in migraine headache: a comprehensive review on literature

Cited by 48 publications

References 122 publications

The association between dietary acid load and the migraine odds

The association between dietary acid load and the migraine odds

Does Atorvastatin Help Prevent Classic Migraine Attacks? A Triple-Blind Controlled Clinical Trial

Best Practice London: focus on lipid and migraine management

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