Vitamin D in autoimmune liver disease

Smyk, Daniel S.; Orfanidou, Timoklia; Invernizzi, Pietro; Bogdanos, Dimitrios P.; Lenzi, Marco

doi:10.1016/j.clinre.2013.05.016

Cited by 48 publications

(32 citation statements)

References 141 publications

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“…BsmI, ApaI, and TaqI SNPs are located in the 3'region of VDR gene in linkage disequilibrium with each other. These polymorphisms are implicated in modulation of several chronic liver diseases such as autoimmune hepatitis (FokI polymorphisms), primary biliary cirrhosis (BsmI polymorphism), primary sclerosing Cholangitis (ApaI polymorphisms) [45] and viral hepatitis [46]. Also, these VDR gene polymorphisms were reported to be associated with risk HCC development in patients with liver cirrhosis [47], chronic hepatitis B [48], alcoholic cirrhotic patients underwent liver transplantation [25] and chronic hepatitis C [27].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

Mohammed¹

2017

GHOA

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Background: Vitamin D has emerging roles in fibrogenesis, cell cycle arrest, immune modulation, and tumorigenesis. Several single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are associated with tumorigenesis in various organs.Objective: to investigate the association between the VDR gene polymorphisms and Hepatocellular carcinoma (HCC) risk and severity in Egyptian patients with chronic hepatitis C (CHC). Methods:Five hundred thirty outpatients with chronic hepatitis C virus (HCV) infection were initially enrolled, of which 180 patients with CHC, 180 patients with liver cirrhosis and 170 patients with HCC. Another 170 age-and sex-matched healthy controls were enrolled. Genotyping of VDR gene at BsmI, ApaI and TaqI loci was performed. Evaluation of clinicopathological features of HCC was done. Data were analyzed using SPSS software (Version 17.0). Results Conclusion:The present study provided significant associations of VDR gene SNPs (ApaI CC genotype and bAt[CCA]-haplotype) with HCC development and disease severity in HCV-infected Egyptian patients. Thus, the determination of these VDR genetic variants in HCV patients could help identification of patients at-risk of HCC development.

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Section: Discussionmentioning

confidence: 99%

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

Mohammed¹

2017

GHOA

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“…The relation between vitamin D deficiency and Ss was shown in previous studies. [1][2][3][4] In our study, none of the patients had autoimmune disease such as Ss, which could affect the TBUT and Schirmer levels. We researched the possible link between non-Ss dry eye and vitamin D deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Vitamin D deficiency has an important role in the development of cancer and several autoimmune diseases. 1,2 It has also been found that environmental and hormonal factors, the fatsoluble vitamins such as vitamin D, may have a role in the pathogenic immunoregulatory process of primary Sjögren's syndrome (Pss). [4][5][6] The vitamin D supplementation is suggested for chronic autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye

Kurtul

Ozer

Aydinli

2015

Eye

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Purpose To investigate the effect of vitamin D deficiency on tear break-up time (TBUT) and Schirmer test scores and to assess their relationship in non-Sjögren dry-eye patients. Methods Thirty-four patients with serum vitamin D deficiency and 21 control subjects with normal vitamin D levels were included in this study. The TBUT and Schirmer-1 test without topical anesthesia were performed to all patients. Results The mean TBUT were 5.18 ± 2.15 and 7.36 ± 3.10 s and Schirmer scores were 12.18 ± 6.44 and 18.57 ± 8.99 mm in the study and control groups, respectively. TBUT scores and Schirmer-1 results of the study group were significantly lower than the control group (P = 0.01 and 0.007, respectively). The mean vitamin D levels were 11.50 ± 1.8 ng/ml in the study group and 32.8 ± 8.72 ng/ml in control group (P = 0.001). Dry-eye symptoms were detected in all patients in the study group and 15% of the patients in the control group. Conclusions We demonstrated that vitamin D deficiency decreases the TBUT and Schirmer test values and may be associated with dry-eye symptoms in non-Sjögren syndrome.

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“…is one of the steroid hormone families and, similar to other members of these families, participates in the regulation of gene expression (Cantorna, 2010;Smyk et al, 2013). On the other hand, calcitriol may be an environmental factor that contributes to immune-mediated disease development.…”

Section: Introductionmentioning

confidence: 99%

Calcitriol modulates the effects of the supernatants of bone-marrow–derived mesenchymal stem cells on neutrophil functions

Galeh¹,

Delirezh²,

Froushani³

et al. 2014

Turk J Biol

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IntroductionComplicated crosstalk between environmental factors and multiple genes determines which individuals will develop any given immune-mediated disease (Cantorna, 2010). Calcitriol [1α-25(OH)-vitamin D3] is one of the steroid hormone families and, similar to other members of these families, participates in the regulation of gene expression (Cantorna, 2010;Smyk et al., 2013). On the other hand, calcitriol may be an environmental factor that contributes to immune-mediated disease development. Environmental sources of calcitriol include diet and production in the skin following UV exposure to precursor 7-dehydrocholesterol (Namgung et al., 1994).Bone-marrow-derived mesenchymal stem cells (MSCs) are multipotent and can give rise to mesenchymal tissues like bone, cartilage, and fat (Uccelli et al., 2008). They also have potent immunomodulatory properties and may be valuable tools for cell-based immunotherapy (Meirelles Lda et al., 2009;Ghannam et al., 2010;Zhang et al., 2013). MSCs in bone marrow and tissue form a niche that has inevitable interactions with hematopoietic cells including neutrophils (Raffaghello et al., 2008;Maqbool et al., 2011). Neutrophils are one of the major cell types that constitute innate immunity. They predominate in host tissues during acute inflammatory processes (Greenberg and Grinstein, 2002).Recent documents have shown that calcitriol has an important role in regulating the growth of MSCs (Artaza et al., 2010;Klotz et al., 2012). The present study was carried out to investigate the effects of calcitriol on the interaction between bone-marrow-derived MSCs and neutrophils in rats. Materials and methods MaterialsPropidium iodide, acridine orange, and phosphatebuffered saline (PBS) were procured from Sigma-Aldrich (St Louis, MO, USA). May-Grünwald-Giemsa stain was purchased from Merck (Darmstadt, Germany) and dextran was obtained from Fresenius Kabi (Verona, Italy). Fetal calf serum, Dulbecco's Modified Eagle Medium (DEMEM), and RPMI 1640 were purchased from GIBCO/Life Technologies Inc. (Gaithersburg, MD, USA). The enzymelinked immunosorbent assay (ELISA) kit for interleukin (IL)-6 was purchased from Bender MedSystems

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Vitamin D in autoimmune liver disease

Cited by 48 publications

References 141 publications

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye

Calcitriol modulates the effects of the supernatants of bone-marrow–derived mesenchymal stem cells on neutrophil functions

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