Vitamin D in autoimmune, infectious and allergic diseases: A vital player?

Belle, Tom L. Van; Gysemans, Conny; Mathieu, Chantal

doi:10.1016/j.beem.2011.04.009

Cited by 110 publications

(71 citation statements)

References 152 publications

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“…Numerous studies demonstrated that 1,25(OH) 2 D 3 has an immunosuppressive activity by stimulation of the innate immune system and by suppression of the adaptive immune system (457). Because chronic inflammation is regarded as a risk factor for the development of cancer, the suppression of inflammation by 1,25(OH) 2 D 3 may contribute to its antineoplastic activity.…”

Section: D) Effects On Inflammation In Cancermentioning

confidence: 99%

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Christakos

Dhawan

Verstuyf

et al. 2016

Physiological Reviews

1,435

1,234

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, [1,25(OH) 2 D 3 ] is the hormonally active form of vitamin D. The genomic mechanism of 1,25(OH) 2 D 3 action involves the direct binding of the 1,25(OH) 2 D 3 activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodimeric complex to specific DNA sequences. Numerous VDR co-regulatory proteins have been identified, and genome-wide studies have shown that the actions of 1,25(OH) 2 D 3 involve regulation of gene activity at a range of locations many kilobases from the transcription start site. The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange. These recent technological advances will result in a more complete understanding of VDR coactivator interactions, thus facilitating cell and gene specific clinical applications. Although the identification of mechanisms mediating VDR-regulated transcription has been one focus of recent research in the field, other topics of fundamental importance include the identification and functional significance of proteins involved in the metabolism of vitamin D. CYP2R1 has been identified as the most important 25-hydroxylase, and a critical role for CYP24A1 in humans was noted in studies showing that inactivating mutations in CYP24A1 are a probable cause of idiopathic infantile hypercalcemia. In addition, studies using knockout and transgenic mice have provided new insight on the physiological role of vitamin D in classical target tissues as well as evidence of extraskeletal effects of 1,25(OH) 2 D 3 including inhibition of cancer progression, effects on the cardiovascular system, and immunomodulatory effects in certain autoimmune diseases. Some of the mechanistic findings in mouse models have also been observed in humans. The identification of similar pathways in humans could lead to the development of new therapies to prevent and treat disease.

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Section: D) Effects On Inflammation In Cancermentioning

confidence: 99%

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Christakos

Dhawan

Verstuyf

et al. 2016

Physiological Reviews

1,435

1,234

View full text Add to dashboard Cite

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“…Vitamin D is known to have a role in CF-related inflammation, diabetes, and the differentiation of lymphocytes (39). The lymphocytes function is susceptible not only to hyperglycemia (40) but also to non-optimal levels of vitamin D which could both trigger the abnormal immune response observed in CF (41,42) and might promote inappropriate immune responses of Th17 and Treg cells and, in turn, possibly contribute to the deterioration of lung function, as well as the development of CFRD (43). However, human data supporting the decrease in b-cell mass by hypovitaminosis D are currently lacking.…”

Section: B-cell-specific Dysfunctionmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Cystic fibrosis-related diabetes: novel pathogenic insights opening new therapeutic avenues

Barrio¹

2015

European Journal of Endocrinology

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Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR). CFTR is primarily present in epithelial cells of the airways, intestine and in cells with exocrine and endocrine functions. Mutations in the gene encoding the channel protein complex (CFTR) cause alterations in the ionic composition of secretions from the lung, gastrointestinal tract, liver, and also the pancreas. CF-related diabetes (CFRD), the most common complication of CF, has a major detrimental impact on pulmonary function, nutrition and survival. Glucose derangements in CF seem to start from early infancy and, even when the pathophysiology is multifactorial, insulin insufficiency is clearly a major component. Consistently, recent evidence has confirmed that CFTR is an important regulator of insulin secretion by islet b-cells. In addition, several other mechanisms were also recognized from cellular and animals models also contributing to either b-cell mass reduction or b-cell malfunction. Understanding such mechanisms is crucial for the development of the so-called 'transformational' therapies in CF, including the preservation of insulin secretion. Innovative therapeutic approaches aim to modify specific CFTR mutant proteins or positively modulate their function. CFTR modulators have recently shown in vitro capacity to enhance insulin secretion and thereby potential clinical utility in CFDR, including synergistic effects between corrector and potentiator drugs. The introduction of incretins and the optimization of exocrine pancreatic replacement complete the number of therapeutic options of CFRD besides early diagnosis and implementation of insulin therapy. This review focuses on the recently identified pathogenic mechanisms leading to CFRD relevant for the development of novel pharmacological avenues in CFRD therapy.

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“…2,3 Bentuk aktif vitamin D penting untuk meme-ngaruhi sel imun dan dibutuhkan tubuh untuk memproduksi interleukin mediator yang dibutuhkan tubuh dalam melawan virus dengue. 4 Vitamin D mempunyai fungsi penting dalam menghambat pelepasan pro-inflamatori yang berlebihan, seperti TNF-α, INF-γ, dan IL-12 yang menjadi pemicu disfungsi endotel sehingga menyebabkan kebocoran plasma 5 sehingga vitamin D penting untuk mencegah DBD yang lebih parah pada penderitanya.…”

Section: Pendahuluanunclassified

Asupan Vitamin D Rendah dan Keparahan Demam Berdarah Dengue pada Anak Usia 1-14 Tahun

Siyam¹,

Wilopo²,

Hakimi³

2014

Kesmas: National Public Health Journal

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AbstrakDemam berdarah dengue (DBD) menimbulkan syok dan kematian. Penderita DBD di Yogyakarta sebagian besar usia 1 -12 tahun dengan DBD parah. Asupan vitamin D rendah diasumsikan penyebab DBD parah. Asumsi ini perlu dibuktikan dengan menganalisis pengaruh asupan Vitamin D dan keparahan DBD. Rancangan penelitian adalah studi kasus kontrol. Penelitian di bangsal rawat inap anak dan instalasi catatan medik RS Jogja dan RSUP Dr. Sardjito. Kasus adalah anak usia 1 -14 tahun dengan DBD grade III & IV, kontrolnya DBD grade I & II. Data asupan vitamin D diambil dengan food frequency questionnaire (FFQ). Variabel luar adalah indeks massa tubuh (IMT), usia, status penyakit kronis dan intensitas terpapar matahari pagi. Analisis dengan uji-t dan regresi logistik. Hasil penelitian didapatkan 60 kasus dan 60 kontrol tanpa matching. Cut-off point asupan vitamin D berdasarkan ROC curve adalah 2,7 µg/hari. Penderita DBD parah rata-rata asupan vitamin D 1,10 kali lebih sedikit dibandingkan DBD tidak parah. Rata-rata asupan vitamin D lebih rendah 1 µg/day bersama IMT ≥18,75 kg/m 2 , penyakit kronis, dan kurang terpapar matahari pagi berpengaruh pada DBD parah (OR=0,47; 95% CI: 0,32-0,71). Cukup Asupan vitamin D disarankan untuk menghindari keparahan DBD. Penyakit kronis dan berat badan lebih perlu menjadi perhatian tenaga medis sebagai kewaspadaan dini terjadinya shock.Kata Kunci: Anak usia 1 -14 tahun, asupan vitamin D, demam berdarah dengue, tingkat keparahan Abstract Dengue hemorrhagic fever (DHF) lead to shock and death. Patient in Yogyakarta mostly aged 1 -12 years old with severe dengue. A low vitamin D intake is assumed to be the cause of severe dengue. This assumption needs to be proved by analyzing the effect of vitamin D intake and severity of DHF. Study design was a case control study. Research on children's wards and medical record installation in hospital. Cases were children with DHF grade III and IV, the control of DHF grade I & II. Data vitamin D intake was obtained by FFQ. Outer variables: BMI, age, chronic diseases and intensity morning sun exposure. Analysis by t-test and logistic regression. The results showed 60 cases and 60 controls without matching. Cut-off point vitamin D intake based ROC curve was 2.7 µg/day. Patients with severe dengue average vitamin D intake of 1.10 times less than not severe dengue. The average vitamin D intake lower 1 µg/day with a BMI ≥ 18.75 kg/m 2 , chronic disease, and less exposed to the morning sun effect on severe dengue (OR = 0.47, 95% CI: 0.32 to 0.71). Sufficient vitamin D intake is recommended to avoid the dengue severity. Chronic diseases and more weight should be a concern of medical personnel as early warning shock occurrence.Keywords: Children 1 -14 years old, vitamin D intake, dengue hemorrhagic fever, severity PendahuluanPenyakit demam berdarah dengue (DBD) merupakan vector-born disease yang potensial menyebabkan kejadian luar biasa (KLB) dan kematian. Sebagian besar penderita DBD pada usia anak dapat mengalami dengue shock syndrome (DSS). Kondisi imunitas anak yang ...

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Vitamin D in autoimmune, infectious and allergic diseases: A vital player?

Cited by 110 publications

References 152 publications

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

MANAGEMENT OF ENDOCRINE DISEASE: Cystic fibrosis-related diabetes: novel pathogenic insights opening new therapeutic avenues

Asupan Vitamin D Rendah dan Keparahan Demam Berdarah Dengue pada Anak Usia 1-14 Tahun

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