Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis

Quirk, Shannon K.; Rainwater, Ellecia; Shure, Anna K.; Agrawal, Devendra K.

doi:10.1586/1744666x.2016.1171143

Cited by 30 publications

(32 citation statements)

References 72 publications

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“…Similarly, an inverse correlation was found between maternal 25OHD levels and the development of eczema and asthma in children and, in adults, between 25OHD and asthma in the NHANES survey . The majority, although not all, of studies have shown an inverse correlation between 25OHD and atopic dermatitis . RTCs have not been plentiful, large, or consistent, although a meta‐analysis of four trials with vitamin D supplementation in atopic dermatitis demonstrated benefit …”

Section: Immune System and Immunologic Diseasesmentioning

confidence: 98%

Extraskeletal actions of vitamin D

Bikle

2016

Annals of the New York Academy of Sciences

156

110

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The vitamin D receptor (VDR) is found in nearly all, if not all, cells in the body. The enzyme that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1, likewise is widely expressed in many cells of the body. These observations indicate that the role of vitamin D is not limited to regulation of bone and mineral homeostasis, as important as that is. Rather, the study of its extraskeletal actions has become the major driving force behind the significant increase in research articles on vitamin D published over the past several decades. A great deal of information has accumulated from cell culture studies, in vivo animal studies, and clinical association studies that confirms that extraskeletal effects of vitamin D are truly widespread and substantial. However, randomized, placebo controlled clinical trials, when done, have by and large not produced the benefits anticipated by the in vitro cell culture and in vivo animal studies. In this review, I will examine the role of vitamin D signaling in a number of extraskeletal tissues, and assess the success of translating these findings into treatments of human diseases affecting those extracellular tissues.

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Section: Immune System and Immunologic Diseasesmentioning

confidence: 98%

Extraskeletal actions of vitamin D

Bikle

2016

Annals of the New York Academy of Sciences

156

110

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“…Poole et al [19] in their study conducted on infants showed that vitamin D insufficiency is associated with an increased risk of a challenge-proven peanut/egg allergy. Quirk et al [20] suggest that vitamin D deficiency increases the risk of sensitization to food allergens, particularly to milk and wheat. In our study, we found a statistically significant correlation between nettle rash and comorbidity asthma (with one or more allergic diseases) and lower mean vitDs level (p = 0.005), which we consider to be interdependence.…”

Section: Discussionmentioning

confidence: 99%

Dependence of the allergic status markers on the level of vitamin D in the serum

Dajic

Stojkovic²,

Novkovic

et al. 2019

Srp Arh Celok Lek

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Introduction/Objective Recent researches show a link between low vitamin D serum levels and increased prevalence of allergic disease. The objective of this study was to show whether there is any dependence of the allergic status markers: skin prick test (SPT), total immunoglobulin E IgE (tIgE), and allergen-specific IgE (sIgE ≥ 3 class) in serum from the serum 25(OH)D (vitDs) level in children with allergic disease/s. Methods A total of 150 children with allergic disease/s were enrolled into this study. The vitDs, tIgE, SPT, and sIgE ≥ 3 class for aeroallergens and common food allergens were simultaneously assessed. Results We found a negative correlation between vitDs level and age groups and a statistically significant positive correlation between vitDs level and tIgE, sIgE ≥ 3 class for hen's egg yolk and hen's egg white. A statistically significant positive correlation was determined between vitDs level and SPT on Dermatophagoides pteronyssinus, and a negative correlation between tIgE and SPT on Dermatophagoides pteronyssinus, as well as between vitDs level and sIgE ≥ 3 class for Cladosporium and Alternaria molds. We confirmed the dependence of nettle rash and comorbidity asthma from the vitamin D insufficiency and vitamin D deficiency. We did not find any dependence of serum tIgE on vitDs level for the sample. Conclusion In order to get an adequate insight into the allergic status in children, we must take into account the pleotropic effects of vitamin D, according to which we suggest that, in the future, vitDs level should be determined synchronously with known markers of allergic status.

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“…Neuere Untersuchungen weisen darauf hin, dass auch Vitamin D, welches nach UV-Bestrahlung in der Haut gebildet wird, mit dem atopischen Ekzem in Zusammenhang steht. In der Literatur sind bis heute zahlreiche Studien zu finden, die entweder eine inverse Assoziation, eine direkte Assoziation und auch keine Assoziation zwischen dem 25-OH-Vitamin-D-Status und einer atopischen Dermatitis zeigen [11]. Jedoch zeigt die überwiegende Zahl der Studien eine schützende Bedeutung von Vitamin D bei Patienten mit atopischer Dermatitis.…”

Section: Umwelt Und Mikrobiomunclassified

Atopische Dermatitis

Worm¹

2017

Akt Dermatol

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Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis

Cited by 30 publications

References 72 publications

Extraskeletal actions of vitamin D

Extraskeletal actions of vitamin D

Dependence of the allergic status markers on the level of vitamin D in the serum

Atopische Dermatitis

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