Vitamin D in 2020: An Old Pro-Hormone with Potential Effects beyond Mineral Metabolism

Courbebaisse, Marie; Cavalier, Étienne

doi:10.3390/nu12113378

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…Vitamin C (ascorbic acid) cannot be synthesized by the human organism, but it is found in many fruits and vegetables [ 17 , 18 , 19 ] and is used as a supplement, alone or in combination with other vitamins and minerals [ 20 ]. Vitamin D exists in two forms: vitamin D2 (found in plants) and vitamin D3 (found in food and synthesized in the skin under sunlight ultraviolet-B ray exposure), both of which are available in dietary supplements [ 21 , 22 ]. An indoor lifestyle, sun avoidance for health or cultural reasons, and a modern diet based on highly processed food are significant contributors to the evolution of global vitamin D deficiency [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

Turcu-Știolică

Bogdan

Subtirelu

et al. 2021

JCM

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Community pharmacists are essential front-line health workers, involved in relieving the COVID-19 burden. Their health-related quality of life status needs to be assessed, as lower levels could affect their functioning. In order to evaluate the current status of community pharmacists’ quality of life from Romania and Bulgaria during the COVID-19 pandemic, and to identify factors associated with their decision on being vaccinated to prevent COVID-19, an online survey involving 395 community pharmacists was conducted from July 15th, 2020 to August 15th, 2020. The 15D instrument was used for quality-of-life assessment. The pharmacists’ recommendations for vitamin C and D intake during the COVID-19 pandemic were also analyzed in order to promote future training programs for community pharmacists. Descriptive statistics, comparative analyses between pharmacists from Romania and Bulgaria, and multiple correlation analyses were performed on the collected data. Significant differences were observed for the level of quality of life between the two groups of pharmacists according to their age; smaller values, directly correlated with their age (total 15D score and age: Spearman r = 0.168, p = 0.022), were obtained for Bulgarian pharmacists regarding sleeping, usual activities, mental function, discomfort and symptoms, depression, distress. The perception of being vaccinated did not differ between Romanian and Bulgarian pharmacists, as almost 50% agreed to vaccination (p = 0.7542). Their willingness to vaccinate was correlated with vitamin D usage (p = 0.0134), rather than with vitamin C (p = 0.4157). No other significant associations were found between willingness to get vaccinated to prevent COVID-19 and other characteristics (age, gender, income, quality-of-life markers). Evidence-based interventions are required to enhance the health-related quality of life of community pharmacists involved in the first line of the COVID-19 pandemic.

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Section: Introductionmentioning

confidence: 99%

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

Turcu-Știolică

Bogdan

Subtirelu

et al. 2021

JCM

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“…Esophageal, gastric, duodenal, and rectal epithelial cells have been shown to express the ACE2 receptor; in fact, plasma cells and lymphocytes indicating the activation of immune cells of the mucosa have been observed in the lamina propria of these organs [ 8 ]. Vitamin D (VD) is a fat-soluble vitamin with a pleiotropic effect on many tissues and organs, and is today considered a pro-hormone [ 9 ]. Among the most important biological roles of VD are controlling bone rearrangement, having an effect on both osteoblasts and osteoclasts, and absorbing calcium and phosphorus intestinally, facilitating their homeostasis [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D (VD) is a fat-soluble vitamin with a pleiotropic effect on many tissues and organs, and is today considered a pro-hormone [ 9 ]. Among the most important biological roles of VD are controlling bone rearrangement, having an effect on both osteoblasts and osteoclasts, and absorbing calcium and phosphorus intestinally, facilitating their homeostasis [ 9 , 10 ]. Nevertheless, many additional roles have been described for VD, from drug metabolism to the control of the immune response [ 1 , 9 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Possible Impact of Vitamin D Status and Supplementation on SARS-CoV-2 Infection Risk and COVID-19 Symptoms in a Cohort of Patients with Inflammatory Bowel Disease

Nicolò

Cusato

Bezzio³

et al. 2022

Nutrients

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The coronavirus disease (COVID-19) pandemic represents a global health challenge, particularly considering concomitant diseases. Patients with inflammatory bowel diseases (IBD) can be considered a population at risk. On the other hand, the risk of developing IBD and COVID-19 have both been described as modulated by vitamin D (VD) levels. In this work, a cohort of 106 adult patients affected by IBD was prospectively enrolled, during the second wave of the pandemic in Italy. In these patients, VD plasma levels, demographic, and clinical characteristics were tested for a correlation/an association with the risk of infection with SARS-CoV-2 in the study period (anti-spike IgG positivity) and the severity of COVID-19 symptoms. By multivariate logistic regression analysis, VD supplementation (Odds Ratio; OR 0.116, p = 0.002), therapy with monoclonal antibodies (OR 0.227, p = 0.007), and the use of mesalazine (OR 2.968, p = 0.046) were found to be independent predictors of SARS-CoV-2 positivity. Moreover, hypertension was associated with severe disease (p = 0.019), while a VD level higher than 30 ng/mL (p = 0.031, OR 0.078) was associated with asymptomatic infection. No interplay between IBD activity and COVID-19 risk of infection or symptoms was observed. These results confirm the importance of VD levels in defining the risk of COVID-19 and give encouraging data about the safety of maintaining immunomodulatory treatments for IBD during the COVID-19 pandemic.

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“…Vitamin D was first discovered in the early 20th century and was considered to be a fat-soluble vitamin. Recent studies have demonstrated that vitamin D plays numerous roles as a prohormone in the human body [ 1 ], and is mainly involved in bone and calcium metabolism [ 2 3 ]. Vitamin D is produced in the skin through exposure to adequate sunlight, or is ingested in the form of vitamin D 2 (ergocalciferol) and vitamin D 3 through food.…”

Section: Introductionmentioning

confidence: 99%

Evidence and suggestions for establishing vitamin D intake standards in Koreans for the prevention of chronic diseases

Kim

Park²,

Pae

et al. 2022

Nutr Res Pract

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BACKGROUND/OBJECTIVES Vitamin D is produced in the skin during sun exposure and is also ingested from foods. The role of vitamin D needs to be considered in the prevention and management of various diseases. Moreover, since the majority of Koreans spend their days indoors, becoming susceptible to the risk of vitamin D deficiency. The current study aims to prepare a basis for determining dietary reference intake of vitamin D in Korea, by reviewing the evidence against various diseases and risks. MATERIALS/METHODS Literature published in Korea and other countries between 2014 and 2018 was prioritized based on their study design and other criteria, and evaluated using the RoB 2.0 assessment form and United States Department of Agriculture Nutrition Evidence Library Conclusion Statement Evaluation Criteria. RESULTS Of the 1,709 studies, 128 studies were included in the final systematic analysis after screening. To set the dietary reference intakes of vitamin D based on the selected articles, blood 25(OH)D levels and indicators of bone health were used collectively. Blood vitamin D levels and ultraviolet (UV) exposure time derived from the Korean National Health and Nutrition Examination Survey were analyzed to establish the dietary reference intakes of vitamin D for each stage of the life cycle. The adequate intake levels of vitamin D, according to age and gender, were determined to be in the range of 5–15 μg/day, and the tolerable upper intake level was established at 25–100 μg/day. CONCLUSIONS The most important variable for vitamin D nutrition is lifestyle. A balanced diet comprising foods with high contents of vitamin D is important, as is vitamin D synthesis after UV exposure. The adequate intake level of vitamin D mentioned in the 2015 Dietary Reference Intakes for Korean (KDRI) remained unchanged in the 2020 KDRI for the management of vitamin D nutrition in Koreans.

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Vitamin D in 2020: An Old Pro-Hormone with Potential Effects beyond Mineral Metabolism

Abstract: Vitamin D is not a vitamin but a pro-hormone. [...]

Cited by 8 publications

References 20 publications

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

Possible Impact of Vitamin D Status and Supplementation on SARS-CoV-2 Infection Risk and COVID-19 Symptoms in a Cohort of Patients with Inflammatory Bowel Disease

Evidence and suggestions for establishing vitamin D intake standards in Koreans for the prevention of chronic diseases

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