Vitamin D improves irritable bowel syndrome symptoms: A meta-analysis

Yan, Chenxi; Hu, Chenmin; Chen, Xiaolong; Jia, Xinyi; Zhu, Zhenya; Ye, Diya; Wu, Yuhao; Gong, Rui; Jiang, Mizu

doi:10.1016/j.heliyon.2023.e16437

Cited by 4 publications

(3 citation statements)

References 34 publications

(56 reference statements)

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“…A meta-analysis conducted in 2023 by Yan et al indicates that vitamin D supplementation can alleviate gastrointestinal discomfort associated with IBS, possibly by increasing vitamin D receptor expression and, as a result, attenuating inflammatory responses of the intestinal mucosa. However, researchers indicate that the pathophysiology of the development of IBS is highly complex, making the effects of this vitamin on gastrointestinal motility, visceral hypersensitivity, gut-brain axis function, stress sensation and other factors affecting disease development likely to be much more complicated [ 81 ].…”

Section: Supplementationmentioning

confidence: 99%

Nutrition, Physical Activity and Supplementation in Irritable Bowel Syndrome

Radziszewska,

Smarkusz-Zarzecka,

Ostrowska

2023

Nutrients

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Irritable Bowel Syndrome (IBS) is a chronic, recurrent functional disorder of the intestine diagnosed based on the Rome IV criteria. Individuals suffering from IBS often associate the severity of their symptoms with the food they consume, leading them to limit the variety of foods they eat and seek information that could help them determine the appropriate selection of dietary items. Clear nutritional recommendations have not been established thus far. NICE recommends a rational approach to nutrition and, if necessary, the short-term implementation of a low FODMAP diet. Currently, the FODMAP diet holds the greatest significance among IBS patients, although it does not yield positive results for everyone affected. Other unconventional diets adopted by individuals with IBS lack supporting research on their effectiveness and may additionally lead to a deterioration in nutritional status, as they often eliminate foods with high nutritional value. The role of physical activity also raises questions, as previous studies have shown its beneficial effects on the physical and mental well-being of every individual, and it can further help alleviate symptoms among people with IBS. Supplementation can be a supportive element in therapy. Attention is drawn to the use of probiotics, vitamin D, and psyllium husk/ispaghula. This review aims to analyze the existing scientific research to determine the impact of various food items, physical activity, and dietary supplementation with specific components through dietary supplements on the course of IBS.

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Section: Supplementationmentioning

confidence: 99%

Nutrition, Physical Activity and Supplementation in Irritable Bowel Syndrome

Radziszewska,

Smarkusz-Zarzecka,

Ostrowska

2023

Nutrients

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“…Przeanalizowali oni 6 badań z łączną liczbą 572 uczestników, w czterech z nich dawkowanie witaminy D wynosiło 50000 IU na tydzień, w dwóch pozostałych 3000 i 2000 IU dziennie. Średnia ważona różnic wyniosła -34,88 przy ocenie skali nasilenia objawów, ale nie wykazała skuteczności interwencji w ocenie jakości życia (średnia ważona różnic 3,33) 29 . Badanie to ma wiele ograniczeń, szeroko opisanych przez samych autorów -różny jest czas leczenia, badania były przeprowadzane w różnych krajach (wpływ karnacji i nasłonecznienia) brakuje okresu follow-up, a poziom witaminy D w 5 z 6 uwzględnionych badań wyjściowo był stosunkowo niski.…”

Section: Witamina D W Ibsunclassified

“…Co ciekawe, w badaniu, którego uczestnicy wyjściowo mieli wysoki poziom witaminy D, nie odnotowano zmniejszenia się objawów. Może to świadczyć o przyjmowaniu przez nich witaminy D z dodatkowych źródeł pochodzących z diety lub o tym, że do zredukowania objawów wystarczające jest osiągnięcie normalnego poziomu witaminy, osiągalnego w ramach zwykłej suplementacji 29 .…”

Section: Witamina D W Ibsunclassified

Recent advances in the treatment of functional dyspepsia and irritable bowel syndrome

Bieniasz,

Bigos,

Dendys

et al. 2023

J Educ Health Sport

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Introduction and purpose: While irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common problems in everyday clinical practice, their treatment often remains inefficient. The aim of our work is to present the newest discoveries and research conducted in the topic, while putting special accents on methods available in Poland. We decided to refer to British Society of Gastroenterology guidelines of treatment of IBS and FD as commonly accepted treatment standards in Europe. Description of the state of knowledge: Number of patients suffering from IBS and FD remains high. According to current research, there are some new therapeutical options in IBS: fecal microbiota transplant, spinal catepsin S, olorinab and tenapanor. Methods already being in use in other applications such as vitamin D supplementation, losartan and fecal microbiota transplant are also being investigated. Fecal microbiota transplant seems the most promising one. There are no new treatment options in FD, however there are new research on already used rifaximin and prokinetics, which show their efficacy. Intensive research is being conducted on the use of herbal medicines in treatment of FD. Even though some papers prove the effectiveness of acupuncture we have decided to omit this topic due to its controversial nature. Conclusions: Treatment of IBS and FD remains difficult, there are few advances in that area. Unconventional methods such as herbal medicine and fecal microbiota transplant seem to be gaining in importance.

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Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical Trials

Zeraattalab-Motlagh,

Ranjbar,

Mohammadi

et al. 2024

Nutrition Reviews

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Context There is still debate regarding the effect of nutritional interventions in improving irritable bowel syndrome (IBS) symptoms. Objectives The aim was to examine the evidence certainty and validity of all existing meta-analyses of intervention trials on nutritional interventions in patients with IBS. Data Sources Scopus, PubMed, and Web of Science were reviewed until June 2023. Data Extraction Meta-analyses assessing the impacts of nutritional interventions in adults with IBS were entered. Effect sizes of nutritional interventions were recalculated by applying a random-effects model. GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) was implemented to determine evidence certainty. Results A total of 175 trials in 58 meta-analyses were entered describing the effects of 11 nutritional interventions on IBS-related outcomes. Nutritional interventions had beneficial effects on some IBS-related outcomes. For instance, soluble fiber, peppermint oil, and aloe vera improved IBS symptoms, and vitamin D3 and curcumin improved IBS symptom severity. Tongxieyaofang improved abdominal pain severity and stool frequency. Nevertheless, these outcomes have mainly shown small effects and low to very low evidence certainty. With regard to abdominal pain after probiotic supplementation (relative risk [RR]: 4.04; 95% confidence interval [CI]: 2.36, 6.92; GRADE = moderate) and IBS symptoms after a low–fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet (RR: 1.48; 95% CI: 1.14, 1.93; GRADE = moderate), there was evidence that probiotics and a low-FODMAP diet can confer clinical and favorable effects. Conclusion The current review does not support nutritional interventions for improving IBS symptoms. With regard to probiotics and a low-FODMAP diet, considering limitations like short-term study duration, there was an influential clinical impact. Systematic Review Registration PROSPERO registration no. CRD42023429991.

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Vitamin D improves irritable bowel syndrome symptoms: A meta-analysis

Cited by 4 publications

References 34 publications

Nutrition, Physical Activity and Supplementation in Irritable Bowel Syndrome

Nutrition, Physical Activity and Supplementation in Irritable Bowel Syndrome

Recent advances in the treatment of functional dyspepsia and irritable bowel syndrome

Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical Trials

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