Vitamin D: Implications for ocular disease and therapeutic potential

Reins, Rose Y.; McDermott, Alison M.

doi:10.1016/j.exer.2015.02.019

Cited by 73 publications

(68 citation statements)

References 118 publications

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“…Calcitriol signalling through the nuclear VDR regulates over 900 genes in a micro‐environment‐specific manner (Alexander et al, ; Kongsbak et al, ). In the human eye, the VDR is expressed in the, photoreceptors, RPE, lens, cornea, ganglion cell layer and ciliary body (Johnson et al, ; Reins and McDermott, ). Expression of zebrafish VDR paralogues, vdra and vdrb arising from gene duplication, was validated here in larval eyes at 5 dpf by RT‐PCR.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre‐miR‐21 and VEGF

Merrigan

Kennedy

2017

British J Pharmacology

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Section: Discussionmentioning

confidence: 99%

Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre‐miR‐21 and VEGF

Merrigan

Kennedy

2017

British J Pharmacology

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“…[29–38] Regarding myopia, several previous studies have found that low hydroxyvitamin D is associated with a high prevalence of myopia in young populations. [36,37,39] However, there is controversy as to whether 25(OH)D is an independent factor for progression of myopia. [38–40] To date, the possible independent associations of serum vitamin D levels and sunlight exposure time with myopia have not been sufficiently evaluated.…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D level is associated with myopia in the Korea national health and nutrition examination survey

Kwon

Choi

2016

Medicine

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The aim of this article was to assess the associations of serum 25-hydroxyvitamin D [25(OH)D] and daily sun exposure time with myopia in Korean adults.This study is based on the Korea National Health and Nutrition Examination Survey (KNHANES) of Korean adults in 2010–2012; multiple logistic regression analyses were performed to examine the associations of serum 25(OH)D levels and daily sun exposure time with myopia, defined as spherical equivalent ≤–0.5D, after adjustment for age, sex, household income, body mass index (BMI), exercise, intraocular pressure (IOP), and education level. Also, multiple linear regression analyses were performed to examine the relationship between serum 25(OH)D levels with spherical equivalent after adjustment for daily sun exposure time in addition to the confounding factors above.Between the nonmyopic and myopic groups, spherical equivalent, age, IOP, BMI, waist circumference, education level, household income, and area of residence differed significantly (all P < 0.05). Compared with subjects with daily sun exposure time <2 hour, subjects with sun exposure time ≥2 to <5 hour, and those with sun exposure time ≥5 hour had significantly less myopia (P < 0.001). In addition, compared with subjects were categorized into quartiles of serum 25(OH)D, the higher quartiles had gradually lower prevalences of myopia after adjustment for confounding factors (P < 0.001). In multiple linear regression analyses, spherical equivalent was significantly associated with serum 25(OH)D concentration after adjustment for confounding factors (P = 0.002).Low serum 25(OH)D levels and shorter daily sun exposure time may be independently associated with a high prevalence of myopia in Korean adults. These data suggest a direct role for vitamin D in the development of myopia.

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“…10 Due to its pleiotropic nature, the level of active forms of vitamin D has been associated with various diseases including those related to the eye. 10,11 Furthermore, there is growing evidence regarding the association of vitamin D with chronic pain. 9,12 An increase in the levels of inflammatory cytokines has been reported in DED 13,14 and some with the ability to modulate pain sensation.…”

Section: Introductionmentioning

confidence: 99%

Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms

Shetty

Sethu

Chevour

et al. 2016

Trans. Vis. Sci. Tech.

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PurposeDry eye is associated with inflammation, pain, and discomfort. Vitamin D is known to modulate immune responses and pain. This study investigates the level of serum vitamin D and tear-inflammatory proteins with relation to exaggerated symptoms in patients with mild dry eye.MethodsPatients with mild dry eye signs (Dry Eye Workshop [DEWS] severity grade 1) but with exaggerated symptoms and healthy controls (n = 19, each) were recruited for this cross-sectional study. Schirmer's Test I (mm), tear film break-up time (TBUT; secs), and ocular surface disease index (OSDI) score were recorded. Serum vitamin D level and tear cytokine levels were measured.ResultsThe mean OSDI score in the patient cohort (46 ± 3) was significantly higher than controls (8.4 ± 1.6). TBUT was lower (7.6 ± 0.3 secs) in patients compared with controls (11.0 ± 0.9 secs). Mean Schirmer's Test I value in patients (19.3 ± 1.4 mm) was lower than in controls (30.6 ± 1.9 mm). An inverse correlation was observed between serum vitamin D levels and OSDI score (r = −0.569; P = 0.01). Significantly higher levels of interleukin (IL)-17A/F, interferon (IFN)-γ, monocyte chemotactic protein (MCP)-1, intercellular adhesion molecule (ICAM)-1, IL-4, IL-10, and decreased IL-2 concentrations was observed in the tears of patients compared with controls (P < 0.05).ConclusionDecreased serum vitamin D was associated with exaggerated symptoms in dry eye patients with mild dry eye signs. In addition, altered tear cytokine profile was also observed in these patients.Translational RelevanceVitamin D measurements would aid in the diagnosis and management of dry eye.

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Vitamin D: Implications for ocular disease and therapeutic potential

Cited by 73 publications

References 118 publications

Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre‐miR‐21 and VEGF

Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre‐miR‐21 and VEGF

Serum 25-hydroxyvitamin D level is associated with myopia in the Korea national health and nutrition examination survey

Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms

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