Vitamin D-Fortified Bread Is as Effective as Supplement in Improving Vitamin D Status: A Randomized Clinical Trial

Nikooyeh, Bahareh; Zahedirad, Maliheh; Mohammadi, Mehrdad; Hosseini, Seyed-Mostafa; Abdollahi, Zahra; Foroozan, Salehi; Razaz, Jalaledin Mirzay; Shariátzadeh, Nastaran; Kalayi, Ali; Lotfollahi, Neda; Maleki, Mohammadreza

doi:10.1210/jc.2016-1631

Cited by 48 publications

(40 citation statements)

References 36 publications

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“…For flour fortification, vitamin D in liquid form is spray‐dried and added as a powder to flour or baking premixes . Clinical trials in Finland, Romania, and Iran provide solid evidence of bioavailability and efficacy of vitamin D from fortified bread . Many studies using vitamin D–fortified wheat or maize flour in LMICs support the use of these foods as a vehicle for increasing vitamin D intake.…”

Section: Interventions To Reduce the Prevalence Of Vitamin D Deficienmentioning

confidence: 99%

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Roth

Abrams

Aloia

et al. 2018

Annals of the New York Academy of Sciences

373

322

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Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods rich in vitamin D and inadequate exposure to natural ultraviolet B (UVB) radiation from sunlight, an important proportion of the global population is at risk of vitamin D deficiency. There is general agreement that the minimum serum/plasma 25-hydroxyvitamin D concentration (25(OH)D) that protects against vitamin D deficiency-related bone disease is approximately 30 nmol/L; therefore, this threshold is suitable to define vitamin D deficiency in population surveys. However, efforts to assess the vitamin D status of populations in low- and middle-income countries have been hampered by limited availability of population-representative 25(OH)D data, particularly among population subgroups most vulnerable to the skeletal and potential extraskeletal consequences of low vitamin D status, namely exclusively breastfed infants, children, adolescents, pregnant and lactating women, and the elderly. In the absence of 25(OH)D data, identification of communities that would benefit from public health interventions to improve vitamin D status may require proxy indicators of the population risk of vitamin D deficiency, such as the prevalence of rickets or metrics of usual UVB exposure. If a high prevalence of vitamin D deficiency is identified (>20% prevalence of 25(OH)D < 30 nmol/L) or the risk for vitamin D deficiency is determined to be high based on proxy indicators (e.g., prevalence of rickets >1%), food fortification and/or targeted vitamin D supplementation policies can be implemented to reduce the burden of vitamin D deficiency-related conditions in vulnerable populations.

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Section: Interventions To Reduce the Prevalence Of Vitamin D Deficienmentioning

confidence: 99%

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Roth

Abrams

Aloia

et al. 2018

Annals of the New York Academy of Sciences

373

322

View full text Add to dashboard Cite

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“…1). A total of 5 clinical trials (13)(14)(15)(16)(17) involving 59 to 101 participants ( Table 1). All studies were conducted in adult populations.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were conducted in participants with type 2 diabetes (13-15, 18) and 1 in women only (17). Four studies used dairy products (13,15,(17)(18) as a food source and bread was used in one experiment (14). The daily dose of vitamin D3, 1000 and 2000 IU, and the duration of administration ranged from 8 to 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Food Fortification with Vitamin D in Iranian Adults: A Systematic Review and Meta-Analysis

Nikooyeh

2018

Nutr Food Sci Res

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There are a number of reports showing high prevalence of hypovitaminosis D across Iran. The objective of this study was to evaluate whether food fortification with vitamin D has the potential to increase serum 25(OH)D concentrations in Iranian people. MEDLINE, PubMed, EMBASE, and The Cochrane Central Register of Controlled Trials were searched for randomized controlled clinical trials involvingIranian participants to assess the effect of fortified food either with vitamin D2 or D3 (with or without calcium) versus control on serum 25(OH)D concentrations. Four studies used dairy products as a food source and bread was used in one experiment. The daily dose of vitamin D3, 1000 and 2000 IU, and the duration of administration ranged from 8 to 12 weeks. The moderate heterogeneity was detected across the included studies (P<0.00001; I 2 =55%).Using a random effects analysis (n=193), the efficacy effect was 34.6nmol/L (95% CI: 28.6, 40.8). The present meta-analysis showed that food fortification with vitamin D could be an effective tool to prevent and control hypovitaminosis D and Iranian population will most probably benefit from the vitamin D fortification as a national policy.

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“…Interestingly, a cohort study revealed that circulating concentrations of 25(OH)D, the main biomarker of vitamin D status, below 50 nmol/L was related to new onset obesity in adults (4). Nevertheless, despite some clinical trials showing the fat massdecreasing and anti-inflammatory effects of supplementary vitamin D in adults (5,6,7), actually the relationship between vitamin D deficiency and obesity is still like a "chicken and egg story" (8).…”

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confidence: 99%

Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance

Nikooyeh

Hollis

Neyestani

2020

Preprint

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Background. The association of ADV-36 infection and obesity has been reported in children. The objective of this study was to examine the hypothesis that the association between ADV-36 infection and adiposity may be mediated by sub-optimal vitamin D status of the host.Methods. Ninety one apparently healthy children in different weight categories (normal weight: 33, overweight: 33, obesity: 25) aged 5-18 years were randomly selected from the registered population at National Food and Nutrition Surveillance Program (NFNS). The groups were matched based on age and sex. Anthropometric, biochemical and serological assessments were performed.Results. The amount of anti-ADV36-Ab increased whereas circulating concentrations of 25(OH)D decreased across BMI categories with higher amounts in children with normal weight than in children with overweight and obesity (31.0±16.4, 22.5±10.5 and 21.9±9.8 nmol/L, respectively, p=0.004).Logistic regression analysis revealed that for each unit increment of anti-ADV36-Ab, the chance of increase in weight was 8.5 times (OR: 8.5, p=0.029). Interestingly, when 25(OH)D was introduced into the model, anti-ADV36-Ab was no longer the predictor of weight increment and the chance of increase in weight reduced 5% for each unit increase in 25(OH)D concentration (OR: 0.95, p=0.012).Conclusion. It is suggested that ADV36-induced lipogenesis may be mediated by vitamin D deficiency in children with obesity. BackgroundContributors to childhood obesity are in the "obesogenic environment" of the children including all those aspects in the child's environment that encourages him or her to eat more (usually unhealthy) foods and to have less physical activity (1). One of the proposed potential contributors to obesity is suboptimal vitamin D status. Detection of vitamin D receptor (VDR) and its signaling pathways in adipose tissue indicated that vitamin D could potentially affect development, metabolism and functions of body fat mass (2). Laboratory in vitro studies demonstrated the effect of calcitriol (1,25(OH) 2 D 3 ), the active form of the vitamin, and its inactive metabolites on adipogenesis in murine 3T3-L1 cell line. While VDR knock out (VDR-/-) and 1-α-hydroxylase knock out (CYP27B1 -/-) mice were highly resistant to weight gain due to dietary intake, the over-expression of human VDR in adipose

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Vitamin D-Fortified Bread Is as Effective as Supplement in Improving Vitamin D Status: A Randomized Clinical Trial

Abstract: Vitamin D-fortified bread could be potentially effective in raising circulating 25-hydroxyvitamin D levels of the population to nearly adequate levels.

Cited by 48 publications

References 36 publications

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Efficacy of Food Fortification with Vitamin D in Iranian Adults: A Systematic Review and Meta-Analysis

Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance

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