Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats

Abdel-Wahab, Ali F.; Afify, Mohamed A; Mahfouz, Amal M.; Shahzad, Naiyer; Bamagous, Ghazi A.; Ghamdi, Saeed S. Al

doi:10.1016/j.brainres.2017.08.011

Cited by 19 publications

(8 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Equally important, VC and VD have been used in combination with other agents in the treatment of disease 22–25 . According to our data, the optimal amount of VC or VD when used in treatment should be based on the balanced levels of both VC and VD.…”

Section: Discussionmentioning

confidence: 99%

Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared

Dong

Tian

Jiao

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Vitamin C (VC) and vitamin D (VD) have been widely used as the dietary supplements and in treatment of diseases both independently and in combination. Whether there is a connection between their pathways is critical for their therapeutic applications. Using whole-genome expression profiles, we performed multiple measures of associations, networks, eQTL mappings and expressions of key genes of interest in VC and VD functions. Several key genes in their pathways were found to be associated. Gc and Rgn play important roles connecting VC and VD pathways in mice. The r values of expression levels between Gc and Rgn in mouse spleen, liver, lung, and kidney are 0.937, 0.558, 0.901, and 0.617, respectively. The expression QTLs of Gc and Rgn are mapped onto the same locations, i.e., 68–76 MB in chromosome 7 and 26–36 MB in chromosome 9. In humans, there are positive correlations between CYP27B1 and SLC23A1 expression levels in kidney (r = 0.733) and spleen (r = 0.424). SLC23A2 and RXRA are minimally associated in both mouse and human. These data indicate that pathways of VC and VD are not independent but affect each other, and this effect is different between mice and humans during VC and VD synthesis and transportation.

show abstract

Section: Discussionmentioning

confidence: 99%

Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared

Dong

Tian

Jiao

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In addition, it was previously demonstrated that valproic acid could be responsible for increased oxidative stress and lipid peroxidation with long-term use, possibly through metabolism to reactive epoxide intermediates [ 24 ]. Therefore, it is proposed that neuroprotective antioxidants could be applied as an add-on therapy for epileptic patients, leading to reduced neurodegeneration and epileptogenesis [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Coenzyme Q10 on Liver Injury Induced by Valproic Acid and Its Antiepileptic Activity in Rats

et al. 2022

View full text Add to dashboard Cite

Valproic acid (VPA) has toxic metabolites that can elevate oxidative stress markers, and the hepatotoxicity of VPA has been reported. Coenzyme Q10 (CoQ10) is one of the most widely used antioxidants. The effect of CoQ10 on epileptogenesis and VPA hepatotoxicity were examined. Rats were randomly divided into five groups: the control group received 0.5% methylcellulose by oral gavages daily and saline by intraperitoneal injection three times weekly. The PTZ group received 1% methylcellulose by gavages daily and 30 mg/kg PTZ by intraperitoneal injection three times weekly. The valproic acid group received 500 mg/kg valproic acid by gavage and 30 mg/kg PTZ, as above. The CoQ10 group received 200 mg/kg CoQ10 by gavages daily and 30 mg/kg PTZ, as above. The Valproic acid + CoQ10 group received valproic acid and CoQ10, as above. Results: CoQ10 exhibited anticonvulsant activity and potentiated the anticonvulsant effect of VPA. CoQ10 combined with VPA induced a more significant reduction in oxidative stress and improved the histopathological changes in the brain and liver compared to VPA treatment. In addition, CoQ10 reduced the level of toxic VPA metabolites. These findings suggest that the co-administration of CoQ10 with VPA in epilepsy might have therapeutic potential by increasing antiepileptic activity and reducing the hepatotoxicity of VPA.

show abstract

“…Autism may result from maternal or host autoantibodies that disrupt neurons that regulate social behavior 111 . Schizophrenia represents overactive immune response which results in neurotransmitters dysregulation 112 , 2020, 4 (3), 72-82 pathways in neurodegeneration occurred in epilepsy 113,96,70,114 . Niraula et al, 2017 115 have reviewed the impact of chronic stress on the aging of immune cells.…”

Section: Behavior and Immunitymentioning

confidence: 99%

Impacts of Immune System in an Experimental Social Behavior Model: Review Article

Mahfoz

2020

Journal of Advanced Pharmacy Research

View full text Add to dashboard Cite

There is growing evidence supports the regulatory role of the immune system in neuronal function and mental health. Many studies have demonstrated the impact of the immune system in neurodegenerative disorders. There are beneficial therapeutic effects of targeting the immune system in the management of these disorders. However, there are gaps in the available knowledge and many steps are needed to move forward. Sensory contact model (SCM) is an experimental social behavior model which allows the formation of different psychopathological conditions which are originated between male mice by the repeated agonistic interactions; resemble those in human. SCM has been developed to investigate aggression and submission behaviors. It gives the chance to study the pharmacological actions of novel psychoactive drugs. The current study aims to review the possible relations between the immune system and social behavior; using the SCM as an experimental model of aggression and depression. To encourage the production of novel psychoactive drugs target the immune system and inflammatory pathways.

show abstract

Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats

Cited by 19 publications

References 50 publications

Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared

Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared

The Effect of Coenzyme Q10 on Liver Injury Induced by Valproic Acid and Its Antiepileptic Activity in Rats

Impacts of Immune System in an Experimental Social Behavior Model: Review Article

Contact Info

Product

Resources

About