Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease

Eyles, Darryl W.; Burne, Thomas H. J.; McGrath, John J.

doi:10.1016/j.yfrne.2012.07.001

Cited by 596 publications

(514 citation statements)

References 233 publications

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“…One study examining the effects of supplementation with vitamin D in the first year of life found that an intake of 2000 international units (IU) or more per day was associated with a significant reduced risk of developing a psychotic disorder in males (RR = .23, CI = .06-.95) (McGrath et al, 2004). Furthermore, low vitamin D prenatally could impact on fetal neural development, increasing one's risk of developing a psychotic disorder later in life (Eyles et al, 2013). These findings suggest an association between vitamin D and psychotic disorders.…”

Section: Introductionmentioning

confidence: 94%

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Adamson

Lally

Gaughran

et al. 2017

Psychiatry Research

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(199/ 200)People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1,770 psychosis, n= 8,171 controls) a mean difference in vitamin D levels between both groups of -11.14 ng/ml 0.59 was found.

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Section: Introductionmentioning

confidence: 94%

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Adamson

Lally

Gaughran

et al. 2017

Psychiatry Research

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“…Some mechanisms have been proposed to explain how SOB affects early neurodevelopmental trajectories, including pollution, eating patterns, vitamin D deficits, maternal infections and temperature changes (Currie, Neidell, & Schmieder, 2009;Eyles, Burne, & McGrath, 2013;Schwartz, 2011;Siega-Riz, Savitz, Zeisel, Thorp, & Herring, 2004). In effect, recent epidemiological research has pointed out that seasonality exerts a strong influence on fetal features such as gestation length and birth weight, and that these associations may markedly be compelled by maternal influenza and pregnancy weight gain (Currie et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Season of birth and subclinical psychosis: Systematic review and meta-analysis of new and existing data

Córdova‐Palomera

Calati

Arias

et al. 2015

Psychiatry Research

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Season of birth (SOB) has been shown to modify risk for several health outcomes, including a number of neuropsychiatric disorders. Besides, empirical evidence indicates that subclinical forms of psychosis in the general population share some risk factors with categorical diagnoses of psychosis. Hence, by systematically reviewing and meta-analyzing new and existing data, the current work aimed to determine whether there is evidence to support an association between winter SOB and subclinical psychosis in the general population. Meta-analytic results do not indicate an association between winter SOB and schizotypy in adult populations, though additional reports indicate winter SOB may be a risk factor for psychotic experiences or symptoms in children around 12-15 years (children's meta-analysis OR = 1.12, 95% CI: 1.03-1.21). In the whole new dataset of adults (n = 481, mean age = 22.8 years) the association was not detected, neither in an unadjusted model (OR = 0.89, 95% CI: 0.61-1.29, p = 0.526) nor adjusting for gender and age (β=-0.36, t=-0.64, p=0.521). Overall, results indicate the association between winter SOB and increased subclinical psychosis may hold in children, but not in the broad adult general population.Nevertheless, epidemiological and clinicopathological significance of winter SOB as a risk factor for subclinical psychosis will probably be slight due to the small effect sizes indicated by reports available to date.

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“…Recent studies have shown that lack of vitamin D in the period of pregnancy and/or early infancy is one of the likely risk factor which plays a role in development of autism (34,35). In addition, maternal/neonatal vitamin D inadequacy has recently been suggested as a probable environmental risk factor for ASDs, while it is also interacted in early neurodevelopment, immune system, and gene regulation processes (18,36,37). Various processes in the body are affected by vitamin D, which brain homeostasis, embryogenesis and neurodevelopment, immunological modulation (including the brain's immune system), ageing interacted in gene regulation (18,19,38).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and autism; a review on recent findings

Sotodehasl¹,

Tamadon²,

Malek³

2017

J Parathyr Dis

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Autism is a group of lifelong developmental disabilities with various genetic and environmental risk factors which is generally not curable. The proportion of children with autism spectrum disorders (ASDs) has risen over the past decade. Few studies have focused on vitamin D status of patients with autism. Therefore, this study was aimed to further investigate the relationship between vitamin D deficiency and autism. In this short review, we discuss the relationship between vitamin D deficiency and ASDs. Our literature review yielded over 80 articles published since 2006 in the electronic databases of the Web of Knowledge, EBSCO, OVID and PubMed. As the results showed, no significant difference between children with and without autism regarding vitamin D serum levels was obtained. According to the controversial results on the correlation of vitamin D serum value and autism in children with ASD, it is necessary to conduct further studies in this field.

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Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease

Cited by 596 publications

References 233 publications

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Season of birth and subclinical psychosis: Systematic review and meta-analysis of new and existing data

Vitamin D deficiency and autism; a review on recent findings

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