Vitamin D Dosing Strategies Among Jordanians With Hypovitaminosis D

Khawaja, Nahla; Liswi, Mohammed; El‐Khateeb, Mohammed; Hyassat, Dana; Bajawi, Dalila; ElMohtaseb, M. S.; Alkhateeb, Hussein; Ajlouni, Kamel

doi:10.1177/0897190015626334

Cited by 3 publications

(5 citation statements)

References 60 publications

(106 reference statements)

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“…Thus, 50 000 IU vitamin D3 bimonthly is required to maintain sufficient 25(OH)D levels year-round. In such study, we noticed that the maintenance dose was both high and more frequent compared to others (22). This result is consistent with another study done in healthy adult and elderly subjects with hypovitaminosis that showed; the frequent oral dose of 50.000 IU is more effective in correcting hypovitaminosis (46).…”

Section: Discussionsupporting

confidence: 90%

“…One of our intervention studies (22) showed that, in a fixed short period, no matter the dosage, the frequency or route of administration of vitamin D3 supplementation since the accumulative dose is the same and it produced significantly absolute increase of serum 25(OH) D from baseline and correct the hypovitaminosis. Thus, 50 000 IU vitamin D3 bimonthly is required to maintain sufficient 25(OH)D levels year-round.…”

Section: Discussionmentioning

confidence: 97%

“…Scheck et al revealed that loading dose of 200.000 IU followed by a dose of 100.000 monthly was the best dosing schedule to quickly and safely correct vitamin D status (25). One interesting study (22) evaluated two regimens of vitamin D3 and proved that timing and frequency of the dosing (daily vs weekly) have no different effect on optimizing serum 25(OH)D levels as long as the accumulative dose of vitamin D3 was similar. Our results are consistent with another study showed that supplementation with vitamin D3 was very effective in raising serum 25(OH) D concentrations with larger and more infrequent bolus dosages, but the effect was lost with small daily doses (43).…”

Section: Discussionmentioning

confidence: 99%

“…One very interesting study evaluated two regimens of vitamin D (22). One regimen tested a dose of 50.000 IU weekly for 8 weeks, then monthly for 2 months.…”

Section: Regimen4 Supplement With Multiple Oral Large Dosementioning

confidence: 99%

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Therapeutic and maintenance regimens of vitamin D3 supplementation in healthy adults: A systematic review

Hassan

Hozayen

Alotaibi

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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Studies carried out assessing the effect of different doses of cholecalciferol (vitamin D3) on correcting serum 25-hydroxyvitamin D deficiency in healthy adults are limited and review studies are lacking. Moreover, the maintenance dose and its duration offered by these few studies are inconsistent. We performed a systematic review of randomized clinical controlled trials (RCTs) that assessed the effect of different doses of vitamin D3 on serum 25(OH)D in healthy adults. PubMed database was searched from 2010 to 2018 using the following search terms: "vitamin D deficiency", "Cholecalciferol", "vitamin D3 dose", "vitamin D supplement", "vitamin D therapy". RCTs and original articles that evaluated different doses of vitamin D3 were identified. A total of sixteen (out of 3016) acceptable studies fulfilling our inclusion criteria were included in the current systematic review. Our results revealed that supplementation with vitamin D3 had a significant positive effect in raising serum 25(OH) D concentrations. Our findings indicated that the best regimen of vitamin D3 supplement consisted of an initial large bolus dose either IM injection of 600.000 IU monthly or oral dose of 200.000 IU monthly or 50.000 IU weekly for 8 weeks, followed by a maintenance dose of 50.000 IU monthly or bimonthly. A large bolus therapeutic dose of vitamin D3, frequently or infrequently for 8 weeks, followed by long-term oral maintenance dose of 50.000 IU monthly or bimonthly optimiz and manitain vitamin D serum levels year round.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

“…One very interesting study evaluated two regimens of vitamin D (22). One regimen tested a dose of 50.000 IU weekly for 8 weeks, then monthly for 2 months.…”

Section: Regimen4 Supplement With Multiple Oral Large Dosementioning

confidence: 99%

See 2 more Smart Citations

Therapeutic and maintenance regimens of vitamin D3 supplementation in healthy adults: A systematic review

Hassan

Hozayen

Alotaibi

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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“…In the last few years, several trials comparing different daily or monthly dosing regimens of vitamin D currently adopted worldwide resulted in 20–25% of patients having suboptimal vitamin D status (at least 30 ng/mL), even when 50,000 IU were administered monthly (1600 IU/day) [ 1 , 47 , 48 ]. In addition, the relevant impact on circulating vitamin D levels of variables such as BMI, age or type of supplements will probably lead to a personalized supplementation strategy tailored to the patient.…”

Section: Vitamin D In the Elderlymentioning

confidence: 99%

Vitamin D: Daily vs. Monthly Use in Children and Elderly—What Is Going On?

et al. 2017

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Vitamin D deficiency is highly prevalent among children and adults worldwide. Agreement exists that vitamin D deficiency should be corrected. However, the definitions of vitamin deficiency and effective vitamin D replacement therapy are inconsistent in the literature. Not only is the dosing regimen still under debate, but also the time and period of administration (i.e., daily vs. monthly dose). In pediatric as well as elderly subjects, dosing regimens with high vitamin D doses at less frequent intervals were proposed to help increase compliance to treatment: these became widespread in clinical practice, despite mounting evidence that such therapies are not only ineffective but potentially harmful, particularly in elderly subjects. Moreover, in the elderly, high doses of vitamin D seem to increase the risk of functional decline and are associated with a higher risk of falls and fractures. Achieving good adherence to recommended prophylactic regimens is definitely one of the obstacles currently being faced in view of the wide segment of the population liable to the treatment and the very long duration of prophylaxis. The daily intake for extended periods is in fact one of the frequent causes of therapeutic drop-outs, while monthly doses of vitamin D may effectively and safely improve patient compliance to the therapy. The aim of our paper is a quasi-literature review on dosing regimens among children and elderly. These two populations showed a particularly significant beneficial effect on bone metabolism, and there could be different outcomes with different dosing regimens.

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Dosing Strategy of Vitamin D therapy in Patients with Rheumatic Diseases in Bahrain

Hassan

Naga²,

Mustafa

et al. 2019

AGJSR

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Purpose: The assessment of vitamin D status (25(OH)D) and dosing strategies for patients with rheumatic diseases (RDs) in Bahrain are lacking. The current study aimed to determine serum 25(OH)D levels at baseline and after Cholecalciferol (Vitamin D3) therapy and to assess the changes in serum levels in response to three different regimens in adult patients with RDs in Bahrain. Methods: Data was collected retrospectively from 158 patients with RDs, during a period 20132019- at King Abdullah Medical City. The mean age of the patients was 45 years (range 18 - 83 years). Two third (66.46%, 105) of them were females. The controls were adult sex- and age-matched healthy volunteers. All patients were investigated for vitamin D status during their first visits. Three regimens of Vitamin D3 therapy were assessed: Regimen1. A single parenteral dose of 600.000 IU. Regimen2. An oral dose of 50.000 IU weekly for 12 weeks, Regimen3. Maintenance oral dose whenever a patient achieved an optimal level. Results: The patients had lower serum levels of vitamin D3 compared to controls (P-Value=0.001; 95%C.I. (3.870, 15.599)). There was a statistically significant increase in mean serum levels of Vitamin D3 in Parenteral compared to Oral therapy (P-value<0.0005). In the patient group, vitamin D3 therapy leads to a statistically significant increase in its baseline level (P-value<0.0005), but the reduction in vitamin D3 from the therapeutic levels during maintenance was statistically not significant (P-value=0.177). Conclusion: The significant increase in serum 25(OH)D levels from baseline in response to Vitamin D3 regimens was best achieved with single parenteral therapy of 600.000 IU. Maintenance therapy to maintain optimal level year-round is a must, and the best dose was 50.000 IU orally every 24- weeks.

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Vitamin D Dosing Strategies Among Jordanians With Hypovitaminosis D

Abstract: Timing and frequency of the dosing (daily vs weekly) have no effect on the rise in serum 25(OH)D levels as long as the accumulative dose of cholecalciferol is similar. Cholecalciferol 50 000 IU bimonthly is required to maintain sufficient 25(OH)D levels.

Cited by 3 publications

References 60 publications

Therapeutic and maintenance regimens of vitamin D3 supplementation in healthy adults: A systematic review

Therapeutic and maintenance regimens of vitamin D3 supplementation in healthy adults: A systematic review

Vitamin D: Daily vs. Monthly Use in Children and Elderly—What Is Going On?

Dosing Strategy of Vitamin D therapy in Patients with Rheumatic Diseases in Bahrain

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