Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures

Rostkowska-Nadolska, Beata; Sliupkas-Dyrda, Elektra; Potyka, J; Kuśmierz, Dariusz; Frączek, Marcin; Kręcicki, Tomasz; Kubik, Paweł; Zatoński, Maciej; Latocha, Małgorzata

doi:10.2478/v10039-010-0012-9

Cited by 54 publications

(50 citation statements)

References 32 publications

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“…Vitamin D derivatives have been shown to decrease the levels of both IL-6 and IL-8 in fibroblast cultures derived from nasal polyposis samples. 24 In addition, 25(OH)D has been found to modulate expression of intracellular Toll-like receptor-9 (TLR9) in primary human monocytes, resulting in the subsequent decreased secretion of IL-6 in response to Toll-like receptor-9 challenge. 25 Further evidence supporting a role for vitamin D in suppressing inflammatory pathways potentially active in AI comes from analysis of vitamin D receptor (VDR)-null mice.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

Perlstein

Pande

Berliner

et al. 2011

Blood

102

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Anemia and vitamin D deficiency are conditions that both result in significant morbidity and increase with age. The potential relationship between them remains poorly understood, particularly in the elderly. We used the Third National Health and Nutrition Examination Survey to examine the association of vitamin D deficiency with anemia subtypes in persons aged > 60 years. Vitamin D deficiency was defined as serum levels < 20 ng/mL, and anemia was defined according to World Health Organization criteria. Vitamin D deficiency was associated with anemia prevalence independent of age, sex, or race/ ethnicity (odds ratio, 1.47; 95% confidence interval, 1.06-2.05; P ‫؍‬ .02) and varied significantly by anemia subtype (P overall ‫؍‬ .003). The prevalence of vitamin D deficiency was 33.3% in the nonanemic population, 56% in anemia of inflammation (AI; P ‫؍‬ .008), and 33.0% in unexplained anemia (P ‫؍‬ .55). NonHispanic blacks had a 7-fold increased risk of AI compared with whites, and this was partially attenuated after adjusting for vitamin D deficiency. These data show that vitamin D deficiency is associated with specific subtypes of anemia in the elderly, especially in those with AI. Vitamin D may suppress inflammatory pathways, and studies to determine whether vitamin D supplementation ameliorates AI are warranted. (Blood. 2011;117(10):2800-2806)

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Section: Discussionmentioning

confidence: 99%

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

Perlstein

Pande

Berliner

et al. 2011

Blood

102

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“…The pathogenesis of CRSwNP remains unclear; the disease is believed to be the manifestation of complex inflammatory reactions [2,12]. Some theories consider polyps to be a consequence of conditions that cause chronic inflammation in the nose and nasal sinuses characterized by stromal edema and variable cellular infiltrate [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Allergies have been found to predispose individuals to CRSwNP, as the symptoms of watery rhinorrhea and mucosal swelling were present in the diseases, along with an abundance of eosinophils in the nasal secretions. Some studies have shown that eosinophils are possibly the most important inflammatory cells in the pathogenesis of chronic rhinosinusitis with nasal polyposis [2,15]. Staphylococcus aureus is a common bacterial pathogen that may play an important role in the pathogenesis of CRSwNP via tissue remodeling and eosinophilic inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Nasal polyps (NP) are common chronic non-neoplastic polyps of the nasal or paranasal sinus mucosa. The pathogenesis of NP is still unclear, but the disease is believed to be a manifestation of complex inflammatory reactions [2,3]. These inflammations histopathologically consist of basement membrane thickening, atypical gland formation, goblet cell hyperplasia, inflammatory cell infiltration, and subepithelial edema [4].…”

Section: Introductionmentioning

confidence: 99%

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Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Apuhan¹,

Buğdaycı²,

Alçelik³

et al. 2012

J Aller Ther

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Background: Nasal polyps are common chronic non-neoplastic growths of the nasal or paranasal sinus mucosa. Vitamin D deficiency, in particular, has been linked to a high rate of both infectious and inflammatory diseases, including those of the upper and lower airways. Aim:In this study, we analyzed the association between plasma 25-hydroxy vitamin D (25[OH]D) levels in patients with nasal polyps. Material and method:Sixty patients (31 male and 29 female), whose ages ranged from 18 to 55 years, were enrolled in this prospective, clinical study.Results: Serum levels of 25 (OH) vitamin D were measured by using a 25 (OH) vitamin D enzyme immune assay kit. There were no statistically significant differences between the control and study groups in plasma 25(OH) D levels, gender, or age (p<0.05). Lung Disorders/Injury both graders and then averaged to yield a mean CT bone erosion score for each patient. The graders were blinded to age, race, gender, and 25-hydroxy vitamin D status of the patients [10,11]. Conclusions

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“…899 In addition to suppressing fibroblast proliferation, 1,25VD 3 and tacalcitol inhibited production of the proinflammatory cytokines IL-6, IL-8, and RANTES (an eosinophil/lymphocyte chemoattractant) by activated human NP fibroblasts. 900,901 With regard to suppressing RANTES production, a synergistic effect was observed when budesonide was added to 1,25VD 3 or tacalcitol as compared to monotherapy. Finally, studies on 1,25VD 3 or tacalcitol-exposed fibroblasts did not show a shift in BCL-2/BAX gene expression in a proapoptotic direction.…”

Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures

Cited by 54 publications

References 32 publications

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

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