Vitamin D-Dependent Calcium Binding Proteins: Chemistry, Distribution, Functional Considerations, and Molecular Biology*

Christakos, Sylvia; Gabrielides, Christine; Rhoten, William B.

doi:10.1210/edrv-10-1-3

Cited by 411 publications

(204 citation statements)

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“…Expressed in a variety of organs including kidney, intestine, bone, brain, pancreas, and placenta, its precise function remains the subject of speculation (Christakos et al, 1989). In neural tissues, it may act simply as a calcium buffer (Baimbridge et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

Control of calbindin‐D_28K expression in developing mouse kidney

Davies

1994

Developmental Dynamics

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Section: Introductionmentioning

confidence: 99%

Control of calbindin‐D_28K expression in developing mouse kidney

Davies

1994

Developmental Dynamics

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“…Calbindin-D 28k , CALB1, is a vitamin D dependent, calcium binding protein that is expressed in several tissues including the kidney, pancreas and brain [14]. CALB1 acts to buffer calcium concentration in the blood and tissues, and may have regulatory properties similar to other calcium binding proteins, e.g.…”

Section: Utility and Discussionmentioning

confidence: 99%

GCOD - GeneChip Oncology Database

et al. 2011

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BackgroundDNA microarrays have become a nearly ubiquitous tool for the study of human disease, and nowhere is this more true than in cancer. With hundreds of studies and thousands of expression profiles representing the majority of human cancers completed and in public databases, the challenge has been effectively accessing and using this wealth of data.DescriptionTo address this issue we have collected published human cancer gene expression datasets generated on the Affymetrix GeneChip platform, and carefully annotated those studies with a focus on providing accurate sample annotation. To facilitate comparison between datasets, we implemented a consistent data normalization and transformation protocol and then applied stringent quality control procedures to flag low-quality assays.ConclusionThe resulting resource, the GeneChip Oncology Database, is available through a publicly accessible website that provides several query options and analytical tools through an intuitive interface.

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“…Calbindin belongs to a family of intracellular proteins that have affinity for calcium. Other family members include S-100 protein, calmodulin, parvalbumin, and troponin C (7). Calbindins are acidic proteins that are heat stable.…”

mentioning

confidence: 99%

“…Two major subclasses have been described: D9k and D28k. Calbindin D28k is encoded by a gene located on chromosome 8 that is highly conserved in evolution (7). Ca-D28k is a single polypeptide chain that consists of 261 amino acid residues, with four high-affinity calcium-binding sites.…”

mentioning

confidence: 99%

“…The physiologic function of Ca-D28k is unknown, although it has been postulated that Ca-D28k (and other calbindins) constitutes an intracellular buffering mechanism to adjust calcium to a physiologic level (7). Because calcium is thought to play an important role in apoptosis by stimulating calcium/ magnesium-dependent endonucleases and by modulating calcium/calmodulin-dependent enzymatic activity (8), Ca-D28k may play a role in modulating apoptosis.…”

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confidence: 99%

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Prognostic Implications Of Calbindin-D28k Expression in Lung Cancer: Analysis of 452 Cases

et al. 2000

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Calbindin D28k (Ca-D28k) acts as a buffering system to maintain cellular calcium homeostasis and is thought to play a role in inhibiting apoptosis. The goals of this study were to assess CA-D28k expression in lung carcinomas and to correlate these results with patient survival.A total of 452 lung carcinomas were immunostained with a monoclonal antibody specific for Ca-D28K using an avidin-biotin peroxidase technique. The number of cells with nuclear staining was graded semiquantitatively into one of five groups: 0, fewer than 10%, 10 to 25%, more than 25 to 50%, more than 50 to 75%, and more than 75%. Results were correlated with patient survival using KaplanMeier survival curves.A total of 335 of 452 (74%) lung carcinomas were positive for Ca-D28k. There was no statistically significant difference in the prevalence of Ca-D28k expression in tumors of different histologic type. Kaplan-Meier survival analysis revealed that for patients with adenocarcinoma, those with Ca-D28k-positive tumors had a better overall survival than patients with Ca-D28k-negative tumors (P ‫؍‬ .036). This difference was also significant for patients with Stages I and II adenocarcinomas (P ‫؍‬ .033). No statistically significant difference in prognosis was observed for patients with Stages III and IV adenocarcinomas or for patients with other lung carcinoma types of varying stage.Ca-D28k is commonly expressed in lung carcinomas of all histologic types. For patients with localized adenocarcinoma of the lung, Ca-D28k expression correlated with improved survival. No correlation between Ca-D28k expression and patient survival was found for disseminated adenocarcinoma and for other histologic types of lung carcinoma.

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Vitamin D-Dependent Calcium Binding Proteins: Chemistry, Distribution, Functional Considerations, and Molecular Biology*

Cited by 411 publications

References 0 publications

Control of calbindin‐D_28K expression in developing mouse kidney

Control of calbindin‐D_28K expression in developing mouse kidney

GCOD - GeneChip Oncology Database

Prognostic Implications Of Calbindin-D28k Expression in Lung Cancer: Analysis of 452 Cases

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Vitamin D-Dependent Calcium Binding Proteins: Chemistry, Distribution, Functional Considerations, and Molecular Biology*

Cited by 411 publications

References 0 publications

Control of calbindin‐D28K expression in developing mouse kidney

Control of calbindin‐D28K expression in developing mouse kidney

GCOD - GeneChip Oncology Database

Prognostic Implications Of Calbindin-D28k Expression in Lung Cancer: Analysis of 452 Cases

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Product

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Control of calbindin‐D_28K expression in developing mouse kidney

Control of calbindin‐D_28K expression in developing mouse kidney