Vitamin D Deficiency Is Not Associated with Outcomes in Aneurysmal Subarachnoid Hemorrhage Patients: A Case Control Study

Reyes, Yarelis Alvarado; Pérez, Alexandra; Rodríguez–Vega, Gloria M.

doi:10.1016/j.wneu.2016.10.033

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…However, they did not show a significant difference in 25-hydroxy vitamin D levels between the ruptured and unruptured aneurysm subgroups. Yarelis Alvarado Reyes et al 14 observed 40 patients with aneurysmal subarachnoid hemorrhage (aSAH), and they found a high prevalence of vitamin D deficiency among them, but no difference in clinical outcomes (including death, vasospasm hydrocephalus requiring external ventricular drain, or infections) was observed in patients when compared with the vitamin D group. In addition, because all the experimenters were diagnosed with aSAH, they could not compare their vitamin D levels with those of patients with UIAs.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the level of vitamin D and ruptured intracranial aneurysms

Wei

Yuan

Feng

et al. 2021

Sci Rep

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The purpose of our research is to explore whether vitamin D levels were associated with the rupture of intracranial aneurysms. In this retrospective study, 105 patients diagnosed with ruptured intracranial aneurysms (RIAs) and 185 patients diagnosed with unruptured intracranial aneurysms (UIAs) at The First Affiliated Hospital of Zhengzhou University were recruited from September 2019 to September 2020. Patients’ demographic and clinical information, including vitamin D levels, were recorded and compared. Univariate analysis showed that patients with UIAs had higher vitamin D levels than RIAs (p = 0.019). In addition, there were significant differences in aneurysm location (p < 0.001), aspirin use (p = 0.001), and comorbid diabetes mellitus (p = 0.037) between patients with UIAs and RIAs. Binary logistic regression analysis showed that the level of vitamin D was independently associated with RIAs [odds ratio (OR) 0.960; 95% confidence intervals (CI), 0.926–0.996, p = 0.028].

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Section: Discussionmentioning

confidence: 99%

The relationship between the level of vitamin D and ruptured intracranial aneurysms

Wei

Yuan

Feng

et al. 2021

Sci Rep

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“…Kashefiolasl et al ( 78 ) concluded that vitamin D reduced cerebral vasospasm following SAH by inducing stroma-cell-derived factor 1α, suggesting its potential as a treatment agent for cerebral vasospasm. However, Alvarado Reyes et al ( 79 ) observed that vitamin D deficiency was unrelated to the outcomes of patients with aSAH.…”

Section: Potential Drug Therapy Approaches In Intracranial Aneurysmsmentioning

confidence: 99%

Potential application of peripheral blood biomarkers in intracranial aneurysms

Wu,

Zhao,

Kang

et al. 2023

Front. Neurol.

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Intracranial aneurysm (IA) counts are increasing yearly, with a high mortality and disability after rupture. Current diagnosis and treatment rely on costly equipment, lacking effective indicators for progression prediction and specific drugs for treatment. Recently, peripheral blood biomarkers, as common clinical test samples, reflecting the immune and inflammatory state of the body in real-time, have shown promise in providing additional information for risk stratification and treatment in IA patients, which may improve their outcomes after aneurysm rupture through anti-inflammatory therapy. Therefore, this paper reviewed the progress of potential biomarkers of IAs, including inflammatory blood indicators, cytokines, and blood lipids, aiming to aid individual management and therapy of aneurysms in clinical practices.

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“…7 Patients requiring treatment for cerebral aneurysms have an increased VitD deficiency incidence, 8 and a high VitD deficiency prevalence has been noted among SAH patients. 9 Despite the absence of an association between VitD deficiency and outcomes in a first case-control-study including 33 patients, 9 further studies are needed to assess potential effects of VitD deficiency to reach an evidence-based conclusion.…”

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confidence: 99%

Vitamin D—A New Perspective in Treatment of Cerebral Vasospasm

et al. 2020

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BACKGROUND Cerebral vasospasm (CVS) is a frequent complication after subarachnoid hemorrhage (SAH), with no sufficient therapy and a complex pathophysiology. OBJECTIVE To explore the vitamin D system as a potential treatment for CVS. METHODS 25-vitamin D3 levels tested between 2007 and 2015 and data of SAH patients admitted during the months with a peak vs nadir of VitD3 values were analyzed, retrospectively. We prospectively correlated VitD3 and vasospasm/outcome data in SAH patients admitted in 2017. An experimental mice SAH model and cell culture model were used to investigate the effect of 1,25-dihydroxyvitamin D3 (1,25-VitD3). Additionally, the mediators acting in the VitD mechanism were researched and detected. RESULTS Based on the retrospective analysis demonstrating an increased frequency of vasospasm in SAH patients during the low vitamin D period in winter, we started basic research experiments. Active 1,25-VitD3 hormone attenuated CVS, neurological deficit, and inflammation after intrathecal blood injection in mice. Deletion of the vitamin D receptor in the endothelium or in myeloid cells decreased the protective 1,25-VitD3 effect. Co-culture experiments of myeloid and endothelial cells with blood confirmed the anti-inflammatory 1,25-VitD3 effect but also revealed an induction of stroma-cell-derived factor 1α (SDF1α), vascular endothelial growth factor, and endothelial nitric oxide synthase by 1,25-VitD3. In mice, SDF1α mimicked the protective effect of 1,25-VitD3 against CVS. From bench to bedside, CVS severity was inversely correlated with vitamin D plasma level, prospectively. Patients with more severe CVS exhibited attenuated expression of SDF1α and 1,25-VitD3-responsive genes on circulating myeloid cells. CONCLUSION 1,25-VitD3 attenuates CVS after SAH by inducing SDF1α. However, VitD administration should be tested as optional treatment to prevent CVS.

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Vitamin D Deficiency Is Not Associated with Outcomes in Aneurysmal Subarachnoid Hemorrhage Patients: A Case Control Study

Cited by 7 publications

References 15 publications

The relationship between the level of vitamin D and ruptured intracranial aneurysms

The relationship between the level of vitamin D and ruptured intracranial aneurysms

Potential application of peripheral blood biomarkers in intracranial aneurysms

Vitamin D—A New Perspective in Treatment of Cerebral Vasospasm

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