Vitamin D deficiency is associated with cortical bone loss and fractures in the elderly

Abstract

Introduction The role of vitamin D on bone microarchitecture and fragility is not clear. Objective To investigate whether vitamin D deficiency (25(OH)D <20 ng/mL) increases cortical bone loss and the severity of fractures. Design Cross-sectional study of 287 elderly women with at least one prevalent low-impact fracture. Methods Biochemistry, X-rays to identify vertebral fractures (VFs) and to confirm non-vertebral fractures (NonVFs), and high-resolution peripheral quantitative computed tomography (HR-pQCT) to evaluate bone microstructure. Results Serum 25(OH)D levels were associated with body mass index (BMI: r = −0.161, P = 0.006), PTH (r = −0.165; P = 0.005), CTX (r = −0.119; P = 0.043) and vBMD at cortical bone (Dcomp: r = 0.132; P = 0.033) and entire bone (D100: r = 0.162 P = 0.009) at the distal radius, but not at the tibia. Age and PTH levels were potential confounding variables, but in the multiple linear regressions only BMI (95% CI: 0.11–4.16; P < 0.01), 25(OH)D (95% CI: −0.007 to 1.70; P = 0.05) and CTX (95% CI: −149.04 to 21.80; P < 0.01) predicted Dcomp, while BMI (95% CI: 1.13–4.18; P < 0.01) and 25(OH)D (95% CI: 0.24–1.52; P < 0.01) predicted D100. NonVFs predominated in patients with 25(OH)D <20 ng/mL (P = 0.013). Logistic regression analysis showed a decrease in the likelihood of presenting grade 2–3 VFs/NonVFs for every increase in 25(OH)D (OR = 0.962, 95% CI: 0.940–0.984; P = 0.001), BMI (OR = 0.932, 95% CI: 0.885–0.981; P = 0.007) and D100 at radius (OR = 0.994, 95% CI: 0.990–0.998; P = 0.005). Conclusion In elderly patients with prevalent fractures, vitamin D deficiency was associated with cortical bone loss and severity of fractures.

A Descriptive Study of the Nutritional and Frailty Status of Working and Retired Employees within an Academic Community in the Philippines

“…This is in contrast to other studies that found only a significant proportion of vitamin D deficiency in older persons from 40 % to 65 %. 40,41 Vitamin D deficiency was found to be associated with several known geriatric syndromes as well as a strong association between vitamin D deficiency and increased risk of heart failure and cortical bone loss and fractures in the older person's oral, gastrointestinal, urinary, ocular, and respiratory infections. 40,42 The two main sources of vitamin D are the dietary and the endogenous synthesis.…”

“…40,42 The two main sources of vitamin D are the dietary and the endogenous synthesis. 41 Vitamin D2 (ergocalciferol) is obtained from plants and a small quantity of vitamin D3 (cholecalciferol) is from animal-derived food, the main natural vitamin D source is skin synthesis during Early detection among older individuals with or without diabetes of frailty status is necessary for proper immediate nutritional and medical interventions. Studies have shown that a low protein diet resulted in a significant decline in muscle mass and strength in older women.…”

State of Fragility Fractures Management during the COVID-19 Pandemic

“…It ensures a good level of bone mineralization; in fact, vitamin D deficiency produces serious clinical consequences at the bone level that result in a reduction in bone mass and an increased risk of osteoporotic fractures, in particular of the femur [30][31][32]. Previous observational research has identified vitamin D deficiency as a risk factor for Acute Respiratory Distress Syndrome (ARDS) and ARDS severity [33], which can be a life-threatening complication of COVID-19.…”

Impact of Moriamin Forte on Testicular and Epididymal Damage in Rats with Oligoasthenospermia

“…EAAs cannot be synthesised endogenously and thus require exogenous supplementation. Amino acids and vitamins are used to prevent and treat exercise-induced fatigue, scurvy, rickets, beriberi disease, burns, and fractures [9][10][11][12][13][14], as well as malnutrition in pregnant or lactating women and in children [15,16]. EAAs are raw materials for sperm nucleic acid synthesis.…”