Vitamin D deficiency is associated with disease activity in patients with Crohn’s disease

Ko, Kyoung Ho; Kim, You Sun; Lee, Bo Kyung; Choi, Jong Hyun; Woo, Young Cheol; Kim, Jin Young; Moon, Jeong Seop

doi:10.5217/ir.2018.00022

Cited by 21 publications

(25 citation statements)

References 33 publications

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“…Some studies on CD reported that low levels of vitamin D is associated with Crohn's disease activity, 18,19 while others showed no such association. 7,20 Exploring this relationship is difficult and complex because many variables are involved in evaluating disease activity. In contrast to our findings, Jorgensen et al 21 found an inverse association between serum 25[OH]D and disease activity in CD patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Relationship Between Vitamin D Deficiency and Disease Activity in Patients with Inflammatory Bowel Disease in Ahvaz, Iran</p>

Rasouli¹,

Sadeghi²,

Parsi³

et al. 2020

CEG

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Background and Aims: Previous studies have shown that vitamin D plays an important role in inflammatory bowel disease (IBD). This study was designed to investigate the relationship between vitamin D levels and disease activity in IBD patients in Ahvaz, Iran. Methods: This cross-sectional study was conducted on adult IBD patients referring to the outpatient clinic of gastroenterology at Imam Khomeini Hospital in Ahvaz city, in the southwest of Iran. Each patient's disease activity defined according to Crohn's disease activity index (CDAI) in Crohn's disease (CD) and Truelove score in ulcerative colitis (UC) patients, serum 25[OH]D was measured using the radioimmunoassay method. Vitamin D deficiency was defined as concentration of <20 nmol/L. Results: Studied subjects were 130 UC and 23 CD patients (62.1% females) with a mean age of 37.5 ± 12.35 years. Vitamin D deficiency was present in 99 (64.7%) IBD patients. Fifty-three patients (34.6%) had active disease who, compared with patients in remission, had more frequent low vitamin D levels (80 vs 56.7%, P = 0.017). In UC patients, disease activity was significantly associated with vitamin D deficiency (P = 0.035), but no such relationship was observed in CD patients (P = 0.74). Conclusion: Vitamin D deficiency was significantly associated with disease activity in IBD, especially in UC patients. Therefore, careful monitoring of vitamin D deficiency in these patients is highly recommended. Prospective cohort studies are also needed to determine the role of vitamin D deficiency and its treatment in the clinical course of IBD.

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Section: Discussionmentioning

confidence: 99%

<p>Relationship Between Vitamin D Deficiency and Disease Activity in Patients with Inflammatory Bowel Disease in Ahvaz, Iran</p>

Rasouli¹,

Sadeghi²,

Parsi³

et al. 2020

CEG

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“…As well as regulating bone, calcium, and phosphorus metabolism, Vitamin D has a key role in intestinal defense mechanisms, regulating the adaptive and innate immune systems and suppressing microbial invasion of the epithelium [105,106]. Vitamin D deficiency has been detected in 16% to 95% of IBD sufferers, mainly in CD patients [107]. This may be due to several factors, such as intestinal malabsorption, low exposure to sunlight, lack of physical activity, or insufficient dietary intake.…”

Section: Micronutrientsmentioning

confidence: 99%

Implications of the Westernized Diet in the Onset and Progression of IBD

et al. 2019

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Inflammatory bowel diseases (IBD) are currently considered multifactorial pathologies in which various combined environmental factors act on a genetic background, giving rise to a chronic inflammation of the gastrointestinal tract. Among the various environmental factors, it now seems clear that the diet plays the major role in IBD onset and progression. Several clinical studies have attempted to understand the impact of diet in the development and progression of these diseases in order to establish useful guidelines for their management. However, the modest and sometimes contradictory results did not lead to the definition of shared dietary suggestions. On the other hand, food fads and recommendations based on anecdotal episodes are often followed by IBD patients to improve their diet. This review provides a critical overview of existing data on the role of diet as a risk factor for IBD. The methodology used was that of analyzing the results of clinical studies conducted on diet and IBD over the last 12 years through PubMed, as well as analyzing the most relevant studies on nutrients and their possible roles in IBD through the knowledge of the mechanisms by which they can modulate the microbiota or the intestinal physiology.

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“…Thus, VitD deficiency may play a role in the development of IBD and its severity. Other studies, however, have taken the opposite view of the relationship [15] between VitD and IBD and have left the controversy unresolved for patients with CD [16] and UC [17, 18]. Therefore, to explore this controversy we performed a pooled meta-analysis to investigate and determine the status of VitD in the serum of healthy and non-healthy controls and to study the association between serum 25(OH)D and 1,25(OH) 2 D 3 concentrations and an IBD diagnosis (both UC and CD).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

Liu

Luo

et al. 2019

J Transl Med

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Purpose To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn’s disease (CD) and ulcerative colitis (UC). Methods Three electronic databases: PubMed, EMbase and EBSCOhost CINAHL, were searched for observational studies to measure the relationship between serum levels of vitamin D (VitD) and CD (or UC). Results Fifty-five studies were included in the meta-analysis. We found that mean serum 25(OH)D levels in patients with CD were significantly lower than those in healthy controls (MD: − 3.17 ng/mL; 95% CI − 4.42 to − 1.93). Results from the meta-analysis examining 1,25(OH)2D3 levels in Crohn’s patients revealed higher levels in the CD group than in healthy (MD: 3.47 pg/mL; 95% CI − 7.72 to 14.66) and UC group (MD: 5.05 pg/mL; 95% CI − 2.42 to 12.52). Serum 25(OH)D levels were lower in the UC group than in the healthy control group (MD: − 2.52 ng/mL; 95% CI − 4.02 to − 1.02). In studies investigating the level of 1,25(OH)2D3 in UC and healthy control groups, the level of 1,25(OH)2D3 in the UC groups were found to be higher than that in the control groups (MD: 3.76 pg/mL; 95% CI − 8.36 to 15.57). However, the 1,25(OH)2D3 level in patients with UC was lower than that in CD groups (MD: − 6.71 pg/mL; 95% CI − 15.30 to 1.88). No significant difference was noted between CD patients and UC patients in terms of average serum 25(OH)D levels. Conclusions This study found that VitD levels were inversely related to CD and UC. Serum levels of 25(OH)D were lower in patients with CD and UC than in healthy people, and more than half of the patients had insufficient vitamin D levels. The serum level of 1,25(OH)2D3 in both the CD and UC groups was higher than that in healthy people.

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Vitamin D deficiency is associated with disease activity in patients with Crohn’s disease

Cited by 21 publications

References 33 publications

<p>Relationship Between Vitamin D Deficiency and Disease Activity in Patients with Inflammatory Bowel Disease in Ahvaz, Iran</p>

<p>Relationship Between Vitamin D Deficiency and Disease Activity in Patients with Inflammatory Bowel Disease in Ahvaz, Iran</p>

Implications of the Westernized Diet in the Onset and Progression of IBD

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

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