Vitamin D Deficiency Is Associated With Inflammation in Older Irish Adults

Laird, Éamon; McNulty, Helene; Ward, Mary; Hoey, Leane; McSorley, Emeir M.; Wallace, Jonathan; Carson, Emma; Molloy, Anne M.; Healy, Martin; Casey, Miriam; Cunningham, Conal; Strain, JJ

doi:10.1210/jc.2013-3507

Cited by 182 publications

(136 citation statements)

References 51 publications

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“…Our findings are of importance because little it is known about the relationship between 25(OH)D levels and immune markers of inflammation, especially in the elderly. The few published data coming from observational studies (Amer and Qayyum 2012;Reyman et al 2013;Laird et al 2014;Ngo et al 2010;Peterson and Heffernan 2008) support a primary anti-inflammatory role of vitamin D. In a very recent observational investigation conducted in 957 older Irish adults (>60 years of age), Laird et al (Laird et al 2014) showed a significant association between low vitamin D status (25OH-D <25 nmol/L) and markers of inflammation including IL-6, TNF-α, IL-10, hsCRP, and the ratio of IL-6 to IL-10.…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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In older persons, vitamin D insufficiency and a subclinical chronic inflammatory status frequently coexist. Vitamin D has immune-modulatory and in vitro anti-inflammatory properties. However, there is inconclusive evidence about the anti-inflammatory role of vitamin D in older subjects. Thus, we investigated the hypothesis of an inverse relationship between 25-hydroxyvitamin D (25(OH)D) and inflammatory markers in a population-based study of older individuals. After excluding participants with high-sensitivity C-reactive protein (hsCRP)≥10 mg/dl and those who were on chronic anti-inflammatory treatment, we evaluated 867 older adults ≥65 years from the InCHIANTI Study. Participants had complete data on serum concentrations of 25(OH)D, hsCRP, tumor necrosis factor (TNF)-α, soluble TNF-α receptors 1 and 2, interleukin (IL)-1β, IL-1 receptor antagonist, IL-10, IL-18, IL-6, and soluble IL-6 receptors (sIL6r and sgp130). Two general linear models were fit (model 1-adjusted for age, sex, and parathyroid hormone (PTH); model 2-including covariates of model 1 plus dietary and smoking habits, physical activity, ADL disability, season, osteoporosis, depressive status, and comorbidities). The mean age was 75.1±17.1 years±SD. In model 1, AGE (2014) log(25OH-D) was significantly and inversely associated with log(IL-6) (β±SE=−0.11±0.03, p=<0.0001) and log (hsCRP) (β±SE=−0.04±0.02, p=0.04) and positively associated with log(sIL6r) (β±SE=0.11±0.04, p=0.003) but not with other inflammatory markers. In model 2, log (25OH-D) remained negatively associated with log (IL-6) (β±SE=−0.10±0.03, p=0.0001) and positively associated with log(sIL6r) (β±SE=0.11± 0.03, p = 0.004) but not with log(hsCRP) (β ±SE= −0.01±0.03, p=0.07). 25(OH)D is independently and inversely associated with IL-6 and positively with sIL6r, suggesting a potential anti-inflammatory role for vitamin D in older individuals.

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Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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“…A variety of biologically plausible mechanisms may mediate the hepato-protective role for the active metabolite of vitamin D 3 . 1,25-dihydroxyvitamin D 3 modulates the insulin signaling pathway/IR, suppresses fibroblast proliferation and collagen production, exerts profibrinolytic effects, and modulates macrophage activity and inflammatory cytokine generation (e.g., TNF-alpha, interleukin-6, and other cytokines) [27,57,60,63,64]. Thus, vitamin D 3 deficiency or insufficiency should be ruled out in future studies assessing the association between NAFLD and BMD.…”

Section: Low Bone Mineral Density (Osteoporosis/osteomalacia)mentioning

confidence: 99%

Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?

Targher

Lonardo

Rossini

2015

J Endocrinol Invest

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“…It has been reported that vitamin D could play a key role in immune activation and inflammation [6,7]. Moreover, vitamin D can prevent the destruction of pancreatic betacells and reduce the incidence of diabetes mellitus, possibly secondary to inhibition of proinflammatory cytokines [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Tian

Xiao

et al. 2018

Ann Nutr Metab

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Background/Aims: The mechanism, by which vitamin D influences inflammatory biomarkers in type 2 diabetes mellitus (T2DM), is not very well known. Thus, a meta-analysis of randomized controlled trials was conducted to assess the effect of vitamin D supplementation on some inflammatory biomarkers in T2DM subjects. Methods: We searched randomized controlled trials from PubMed and the Cochrane Library in October 2017 and conducted a meta-analysis to evaluate the effectiveness of vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Either a fixed-effects or a random-effects model was used to calculate pooled effects. Results: We identified 13 studies that met our inclusion criteria. The results indicated that the vitamin D supplementation significant decreased the hs-CRP level by 0.45 μg/mL, whereas the vitamin D supplementation did not influence the TNF-α and IL-6. Subgroup analysis showed that vitamin D significantly lowered hs-CRP by 0.34 μg/mL among trials with a daily vitamin D dose ≤4,000 IU and by 0.31 μg/mL among trials with time of vitamin D supplementation > 12 weeks. Conclusions: Vitamin D supplementation is beneficial for the reduction of hs-CRP inT2DM subjects but does not have a significant influence on TNF-α and IL-6 in T2DM subjects.

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Vitamin D Deficiency Is Associated With Inflammation in Older Irish Adults

Cited by 182 publications

References 51 publications

Relationship between vitamin D and inflammatory markers in older individuals

Relationship between vitamin D and inflammatory markers in older individuals

Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?

Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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