Vitamin D deficiency is associated with high prevalence of diabetes in Kuwaiti adults: results from a national survey

Zhang, Fang Fang; Hooti, Suad Al; Zenki, Sameer Al; Alomirah, Husam; Jamil, Kazi M.; Rao, Aravinda; Jahmah, Nasser Al; Saltzman, Edward; Ausman, Lynne M.

doi:10.1186/s12889-016-2758-x

Cited by 59 publications

(46 citation statements)

References 41 publications

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“…Race is another potential confounder 13 . Although a positive association was observed in studies from the USA 3,4 , Kuwait 5 and Turkey 35 , negative results have been reported in studies from India 7 and Brazil 8 . This observation is strengthened by the findings of Shankar et al 4 , which showed an association between vitamin D levels and the incidence of prediabetes among adults in the USA.…”

Section: Discussionmentioning

confidence: 84%

“…To the best of our knowledge, this is the first study to report this association in a Saudi population. In an analysis of 960 adults enrolled in the first National Nutrition Survey in Kuwait, an almost twofold increase in the odds of prediabetes was found in participants with vitamin D inadequacy and deficiency 5 . Two analyses from the National Health and Nutrition Examination Survey have reported a significant association between low vitamin D levels and prediabetes status 3,4 .…”

Section: Discussionmentioning

confidence: 99%

“…There is a growing debate over the association between low 25hydroxyvitamin D (vitamin D) levels and the risk of diabetes mellitus/prediabetes development 1,2 . A large number of crosssectional studies [3][4][5] , but not all of them [6][7][8] , have shown an inverse association between vitamin D status and impaired glucose tolerance, insulin resistance or diabetes mellitus 9 . Reported data also suggest an association between low vitamin D levels with poor diabetes mellitus control 10,11 and diabetes mellitus related complications 12 .…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Al-Mohaissen

Lee

Alamri

2020

J of Diabetes Invest

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Aims/Introduction Vitamin D levels are negatively correlated with prediabetes risk and hemoglobin A1c levels in individuals with prediabetes. The data are, however, scarce and inconsistent among different populations. We aimed to assess the association of vitamin D with prediabetes risk and hemoglobin A1c levels in young Saudi women with normoglycemia and prediabetes. Materials and Methods We analyzed the data of individuals without diabetes (without diabetes history and hemoglobin A1c <6.4%) from the Princess Nourah bint Abdulrahman University’s non‐communicable diseases student registry. Demographic data, anthropometric and blood pressure measurements, and hemoglobin A1c and vitamin D results were retrieved and analyzed. Results In total, 345 participants were included in the analysis. The prediabetes status showed no association with vitamin D levels, but it was significantly associated with the participants’ weight and body mass index. Additionally, there was no correlation between the levels of vitamin D and hemoglobin A1c across the whole population, even after correction for body mass index. However, in the body mass index subgroups, when individuals with potentially harmful levels of vitamin D (>125 nmol/L) were excluded, a positive association was detected between vitamin D and hemoglobin A1c levels in the underweight individuals. Hemoglobin A1c values showed a positive correlation only with bodyweight and body mass index. Conclusions Vitamin D levels did not predict prediabetes status and showed no correlation with hemoglobin A1c levels in this population. Vitamin D levels’ effect on the risk of prediabetes might be small compared with other well‐established risk factors, such as obesity.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Al-Mohaissen

Lee

Alamri

2020

J of Diabetes Invest

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“… Non-diabetic subject studies for the lowest BMI quartile (18–25): Forest plot shows the correlation between vitamin D status and body mass index (BMI) [ 18 , 20 , 23 , 25 , 27 , 31 , 33 , 34 , 35 , 36 , 43 , 45 , 46 , 52 , 53 ]. A random effect model was used to calculate the correlations and 95% CI ( I 2 = 84.372%, p = 0.000).…”

Section: Figurementioning

confidence: 99%

Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Rafiq

Jeppesen

2018

Nutrients

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The deficiency of vitamin D is prevalent all over the world. Studies have shown that vitamin D may play an important role in the development of obesity. The current study was conducted to quantitatively evaluate the association between serum 25-(OH) vitamin D levels and the risk of obesity in both diabetic and non-diabetic subjects. A systematic review and meta-analysis of observational studies was carried out for that purpose. We searched the Medline, PubMed, and Embase databases throughout all of March 2018. A total of fifty five observational studies for both diabetic and non-diabetic subjects were finally included in the meta-analysis. The data were analyzed by comprehensive meta-analysis software version 3 and the random effects model was used to analyze the data. The meta-analysis showed an overall inverse relationship between serum vitamin D status and body mass index (BMI) in studies of both diabetic (r = −0.173, 95% = −0.241 to −0.103, p = 0.000) and non-diabetic (r = −0.152, 95% = −0.187 to −0.116, p = 0.000) subjects. The evidence of publication bias was not found in this meta-analysis. In conclusion, the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects. Reliable evidence from well-designed future randomized controlled trials is required to confirm the findings from observational studies and to find out the potential regulatory effects of vitamin D supplementation to lower BMI.

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“…Despite being located in high UV index area with sunny climate throughout the year, vitamin D insufficiency is known to be endemic in Gulf Region [20,21]. In studies done in Kuwait, Saudi Arabia and UAE the prevalence of hypovitaminosis D among adult population was reported to be 82.9% and 83.6% and 74%, respectively [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D Status in Newly Diagnosed Cases of MS versus Control Group

Saeedan¹,

Ko²,

Chirakkara³

et al. 2017

J Mult Scler

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Background: Hypovitaminosis D is amongst those strongly suggested risk factors for multiple sclerosis (MS). Although the association of vitamin D deficiency with MS has been established in several studies in recent years, there are not many studies to assess and compare the degree of Hypovitaminosis D status of newly diagnosed patients with multiple sclerosis versus control group worldwide, especially in UAE.

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Vitamin D deficiency is associated with high prevalence of diabetes in Kuwaiti adults: results from a national survey

Cited by 59 publications

References 41 publications

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Hypovitaminosis D Status in Newly Diagnosed Cases of MS versus Control Group

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