Vitamin D deficiency is associated with poor response to active hepatitis B immunisation in patients with chronic kidney disease

T helper cell‑related cytokine gene polymorphisms and vitamin D pathway gene polymorphisms as predictors of survival probability in patients on renal replacement therapy

“…30 However, the above effects do not always result in differences in circulating cytokines in in-vivo studies in which vitamin D is given to patients. 31 Deviations from the T-cell cytokine balance [32][33][34] and low plasma vitamin D concentrations [35][36][37] are related to cardiovascular events 34,37 as well as altered immunocompetence during infections 32,35 and vaccinations. 33,36 Serum parathyroid hormone (PTH) levels are dependent on serum vitamin D concentrations, 38 and T cells are implicated in the mechanism of the PTH action in the bone.…”

“…31 Deviations from the T-cell cytokine balance [32][33][34] and low plasma vitamin D concentrations [35][36][37] are related to cardiovascular events 34,37 as well as altered immunocompetence during infections 32,35 and vaccinations. 33,36 Serum parathyroid hormone (PTH) levels are dependent on serum vitamin D concentrations, 38 and T cells are implicated in the mechanism of the PTH action in the bone. 39 We aimed to check a frequency distribution of polymorphic variants of the genes encoding cytokines/ILs related to Th1 and Th2 cells (IL18 rs360719, IL13 rs20541, IL4R rs1805015, IL12A rs568408, IL12B rs3212227, IL28B rs8099917, IL28B rs12979860, and MCP1 rs1024611) as well as polymorphisms of the vitamin D pathway genes (the vitamin D-binding protein gene, also referred to as the group-specific component gene: GC rs2298849, GC rs1155563, GC rs7041; vitamin D receptor gene: VDR rs2228570, VDR rs1544410; and retinoid X receptor alpha gene: RXRA rs10 776 909, RXRA rs10881578, and RXRA rs749759) in relation to survival probability of patients with ESRD requiring renal replacement therapy (RRT).…”

Impact of vitamin D administration on immunogenicity of trivalent inactivated influenza vaccine in previously unvaccinated children

“…[2][3][4][5][6][7] However, the collected human data are controversial. Zitt et al found that VD deficiency was associated with a poor response to active hepatitis B immunisation in adult patients with chronic kidney disease, 8 whereas Heine et al found that the induction of specific tetanus toxoid immunoglobulin after booster immunisation was significantly greater in adults receiving VD supplementation than in untreated controls. 9 The results of studies of influenza vaccine are equally conflicting.…”

Prophylactic vaccinations in chronic kidney disease: Current status

“…[25][26][27][28][29][30] Active immunization against HBV may be less effective in ESRD patients due to vitamin D deficiency. 31 Vitamin D related genetic background may contribute to lower response to hepatitis B vaccination. The VDR rs1544410 AA genotype may play a negative role (but not as an independent factor) in determining response to hepatitis B vaccination in RRT patients.…”