Vitamin D Deficiency in Traumatic Brain Injury and Its Relationship with Severity of Injury and Quality of Life: A Prospective, Observational Study

Toman, Emma; Bishop, Jonathon R B; Davies, David; Su, Zhangjie; Criseno, Sherwin; Mason, Andrea; Toogood, Andrew; Belli, Antonio

doi:10.1089/neu.2016.4494

Cited by 18 publications

(54 citation statements)

References 44 publications

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“…The studies selected for review represented 12 different populations worldwide. These included United States [25, 29, 30, 34, 36, 39, 41], Canada [31, 38], England [27, 40], Spain [33], Brazil [42], France [24], Switzerland [28], Taiwan [32], Sweden [22], Germany [35], Netherlands [26], and China [26] (Table 1). Levels of care among the 20 studies included 10 community care environments [25, 29, 30, 35–37, 39–42], 8 hospital settings [22, 26–28, 31, 33, 34, 38], and 2 studies that recruited participants from both community and hospital [24, 32].…”

Section: Resultsmentioning

confidence: 99%

“…Levels of care among the 20 studies included 10 community care environments [25, 29, 30, 35–37, 39–42], 8 hospital settings [22, 26–28, 31, 33, 34, 38], and 2 studies that recruited participants from both community and hospital [24, 32]. Half of the studies were cohort design [25–28, 31, 32, 36, 38, 39, 42], nine were cross sectional surveys [25, 29, 30, 33, 35, 37, 40, 41], and one was a randomized control trial [22]. Pickelsimer et al [36] and Selassie et al [37] used the same study sample, which was determined based on the review of the sample size, mean age of study participants, site of data collection, and contributing authors.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, six studies reported fewer than of 10% of the study sample to be older adults [22, 24, 27, 35, 41, 42]. For ten studies in the review, 11–30% of the sample included older adults [25, 26, 28–30, 34, 36–38, 40]. Among 17 studies, less than half of the participants were female [24–30, 32–42], whereas two studies consisted of 55% females [22] and in one study 60% [31] were female participants.…”

Section: Resultsmentioning

confidence: 99%

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Quality of life measures in older adults after traumatic brain injury: a systematic review

et al. 2019

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BackgroundOn average older adults experiencing TBI are hospitalized four times as often, have longer hospital stays, and experience slower recovery trajectories and worse functional outcomes compared to younger populations with the same injury severity. A standard measure of Qol for older adults with TBI would facilitate accurate and reliable data across the individual patient care continuum and across clinical care settings, as well as support more rigorous research studies of metadata.PurposeThe aim of this systematic review was to investigate patient reported Qol measures in studies with older adults post TBI.MethodA systematic review was carried out focusing on the various tools to measure Qol in older adults, ≥ 65 years of age with a diagnosis of TBI. Data bases searched included Medline, Embase, PubMed, CINAHL, and PsychInfo from date of inception to September 25, 2017.ResultsA total of 20 articles met the inclusion criteria. Nine different tools were identified.ConclusionsFindings based on the comparison of reliability and construct validity of the Qol measures reported in this review suggest that no single instrument is superior to all others for our study population. Future research in this field should include the enrollment of larger study samples of older adults. Without these future efforts, the ability to detect an optimal Qol measure will be hindered.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Quality of life measures in older adults after traumatic brain injury: a systematic review

et al. 2019

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“…In a prospective observational study, Vitamin D was significantly lower in patients with severe TBI compared to patients with mild TBI ( n = 95, P = 0.03, CI 95% −23.60–−1.21, mean effect size 12.40 nmol/L). [ 12 ]…”

Section: Itamin D For P mentioning

confidence: 99%

Is Vitamin D deficiency implicated in autonomic dysfunction?

Wadhwania

2017

J Pediatr Neurosci

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Dysautonomia, dysfunction of the autonomic nervous system, presents with heterogeneous clinical features from an imbalanced regulation of the sympathetic and parasympathetic nervous systems. Low Vitamin D levels can explain the heterogeneous clinical features of migraine headaches, cardiac and gastrointestinal dysfunction, and oxidative stress evident in dysautonomia patients. The role of Vitamin D in modulating pain sensitivity has been recently established. However, there is a lack of research and understanding regarding the association between Vitamin D deficiency and autonomic dysfunction. Vitamin D is a neuroactive hormone that modulates autonomic balance, regulating the sympathetic and parasympathetic nervous systems, and has multisystem benefits. The following review explores the literature and addresses the relationship between Vitamin D deficiency and autonomic dysfunction. Overall, this literature review implicates Vitamin D deficiency in autonomic dysfunction and elucidates the potential therapeutic role of Vitamin D in autonomic disorders. PubMed search was performed for English articles from 1996 to 2016. Following keywords: Vitamin D, autonomic dysfunction and orthostatic hypotension, Vitamin D receptor, migraine and traumatic brain injury, Vitamin D, cardiac and gastrointestinal disease, Vitamin D, glutathione, oxidative stress, and serotonin were included. Only articles reporting primary data relevant to the above question were included in the study.

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“…The authors recommend active screening of TBI patients to identify when VDD occurs and to prevent its detrimental effects on healing, morbidity, and CVD. 57 …”

Section: More Severe Traumatic Brain Injury and Lower Quality Of Lifementioning

confidence: 99%

Vitamin D: Way More Important in Critical Care Than We May Have Recognized

Alspach¹

2017

Critical Care Nurse

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Vitamin D Deficiency in Traumatic Brain Injury and Its Relationship with Severity of Injury and Quality of Life: A Prospective, Observational Study

Cited by 18 publications

References 44 publications

Quality of life measures in older adults after traumatic brain injury: a systematic review

Quality of life measures in older adults after traumatic brain injury: a systematic review

Is Vitamin D deficiency implicated in autonomic dysfunction?

Vitamin D: Way More Important in Critical Care Than We May Have Recognized

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