Vitamin D deficiency in pediatric patients using antiepileptic drugs: systematic review with meta-analysis

Junges, Cíntia; Machado, Tania Diniz; Filho, Paulo Ricardo Santos Nunes; Riesgo, Rudimar dos Santos; Mello, Elza Daniel de

doi:10.1016/j.jped.2020.01.004

Cited by 13 publications

(10 citation statements)

References 47 publications

(60 reference statements)

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“…It was proposed that the activity of cytochrome liver enzymes increased by administering multiple ASMs [23] . ASMs can be categorised into weak inducers (topiramate and oxcarbazepine) and potent inducers (phenobarbital, phenytoin, and carbamazepine); it was postulated that more than one mechanism was responsible for each ASMs effect on vitamin D status as well as the individual response to the ASM taken, which is perhaps genetically based [24] , [25] , [26] .…”

Section: Discussionmentioning

confidence: 99%

Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications

Indra Gunawan,

Rochmah,

Faizi

2023

Epilepsy & Behavior Reports

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Section: Discussionmentioning

confidence: 99%

Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications

Indra Gunawan,

Rochmah,

Faizi

2023

Epilepsy & Behavior Reports

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“…Similar to other studies, we found a higher rate of vitamin D deficiency among children receiving enzyme-inducer ASM and children with obesity. In a systematic review with meta-analysis, the prevalence of vitamin D deficiency among children with epilepsy treated with enzyme-inducer ASMs was found to be 33%, compared to 24% for those on non-enzyme inducers [ 28 ]. Another study reported the association between the use of enzyme-inducer ASMs and low vitamin D level in epilepsy patients [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Related Risk Factors of Vitamin D Deficiency in Saudi Children with Epilepsy

et al. 2022

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Background: Vitamin D has a role in the pathogenesis of many medical disorders, especially those of the central nervous system. It is essential in maintaining the bone health of children. However, patients with epilepsy are at high risk of developing vitamin D deficiency due to antiseizure medications (ASMs). Therefore, we aimed to assess the prevalence of vitamin D deficiency and related risk factors in children with epilepsy. Methods: This is the baseline report of a pragmatic, randomized, controlled, open-label trial that assessed the impact of vitamin D supplementation in preventing vitamin D deficiency (NCT03536845). We included children with epilepsy aged 2–16 years who were treated with ASMs from December 2017 to March 2021. Children with preexisting vitamin D metabolism problems, vitamin-D-dependent rickets, malabsorption syndromes, renal disease, and hepatic disease were excluded. The baseline demographic data, anthropometric measurements, seizure types, epilepsy syndromes, ASMs, and seizure control measures were recorded. Blood tests for vitamin D (25-hydroxyvitamin D [25(OH)D), serum calcium, serum phosphorus, and parathyroid hormone levels were performed. Based on vitamin D concentration, patients were categorized as deficient (<50 nmol/L), insufficient (74.9–50 nmol/L), or normal (>75 nmol/L). Results: Of 159 recruited children, 108 (67.92%) had generalized seizures, 44 (27.67%) had focal seizures, and 7 (4.4%) had unknown onset seizures. The number of children receiving monotherapy was 128 (79.0%) and 31 (19.1%) children were receiving polytherapy. The mean vitamin D concentration was 60.24 ± 32.36 nmol/L; 72 patients (45.28%) had vitamin D deficiency and 45 (28.3%) had vitamin D insufficiency. No significant difference in vitamin D concentration was observed between children receiving monotherapy and those receiving polytherapy. The main risk factors of vitamin D deficiency were obesity and receiving enzyme-inducer ASMs. Conclusions: The prevalence of vitamin D deficiency was high among children with epilepsy. Obese children with epilepsy and those on enzyme-inducer ASMs were at increased risk for vitamin D deficiency. Further studies are needed to establish strategies to prevent vitamin D deficiency.

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“…The rate of participants with 8.5 and below is higher in the epilepsy group, and the rate of participants between 8.6-10 and over 10 is higher in the healthy control group (Table 1a). Consequently, the Vitamin D deficiency is thought to indirectly cause secondary hyperparathyroidism, hypocalcemia and, therefore, loss in bone mineral densitometry [10][11][12]. In a study on 596 epileptic patients, 54% of Vitamin D deficiency was observed in enzyme-inducing antiepileptics [13].…”

Section: Demographic Features Of Patients With Epilepsy and Healthy C...mentioning

confidence: 99%

Antiepileptiklerin D vitamini ve kalsiyum düzeylerine etkisi

Yuluğ¹,

Özşimşek²,

ÖKTEM³

2022

Acta Medica Alanya

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Purpose: The purpose of our study is to investigate Vitamin D and calcium levels in epilepsy patients using different antiepileptic agents and to investigate the relationship between vitamin D levels and various factors such as the type of antiepileptic agent, patient age and gender. Methodology: This retrospective case-control study enrolled a total of 290 participants, including 141 epilepsy patients followed up in AlanyaAlaaddinKeykubat University neurology outpatient clinic and 150 healthy individuals who applied to the neurology outpatient clinic for different reasons from January 2018 to January 2021. Demographics, detailed history, use of medications, duration of antiepileptic use, plasma 25-hydroxy Vitamin D and calcium levels of all participants were recorded. Results: The average Vitamin D level was 15.46 in the epilepsy group and 16.95 in the control group. Vitamin D level did not differ significantly by group (p>0.05). No significant relationship was found between age and vitamin D levels in both groups, and Vitamin D levels were statistically significantly lower in women in the epilepsy group. Vitamin D level was below 20 in 69.6% of healthy control group, 78.9% of carbamazepine users, 62.5% of lacosamide users, all lamotrigine users, 66.7% of levatiracetam users, and 72.4% of sodium valproate users. There was no significant relationship between Vitamin D level and the drug used (p>0.05).There was a significant relationship only between calcium level and carbamazepine (p

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Vitamin D deficiency in pediatric patients using antiepileptic drugs: systematic review with meta-analysis

Cited by 13 publications

References 47 publications

Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications

Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications

Prevalence and Related Risk Factors of Vitamin D Deficiency in Saudi Children with Epilepsy

Antiepileptiklerin D vitamini ve kalsiyum düzeylerine etkisi

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