Vitamin D deficiency in Mexican mothers and their newborns

Ochoa-Correa, Erika del Carmen; García-Hernández, Pedro Alberto; Villarreal-Pérez, Jesús Zacarías; Treviño-Garza, Consuelo; Rodrí­guez-Balderrama, Isaías; Villarreal, Laura Elia Martínez-de; Zapata-Castilleja, Carlos A

doi:10.24875/gmm.m18000043

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…In Sweden, a longitudinal study reported that 37% of pregnant women in the first trimester had 25(OH)D concentrations < 20 ng/mL [9], compared with 23% of Canadian women [10]. In Mexico, a previous crosssectional study reported vitamin D deficiency among 61% of women in the third trimester, and 98% of their newborns were vitamin D deficient [11].…”

Section: Introductionmentioning

confidence: 99%

Evidence of the functions of vitamin D in pregnant women in COVID-19: a systematic review

Baptista

Filho

Pereira

et al. 2023

IJN

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Introduction: In the world, about 1 million people suffer from vitamin D deficiency. Vitamin D deficiency in pregnant women increases maternal mortality and morbidity rates. In the scenario of COVID-19, it is known that the immune response, inflammation, and coagulation are modulated by vitamin D activity. Objective: It was to analyze the main considerations of the effects of vitamin D on pregnant women and fetuses in the scenario of COVID-19, presenting the mechanisms of inflammatory and immunological processes in an attempt to mitigate the worsening of comorbidities and deaths. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 210 articles were found, 82 articles were evaluated and 32 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 28 studies with a high risk of bias and 28 studies that did not meet GRADE. Most studies showed homogeneity in their results, with I2 =98.9% >50%. There is a relationship between vitamin D status and the severity of COVID-19 in pregnant women. Vitamin D levels are low in pregnant women with COVID-19. Furthermore, there is a significant difference regarding the level of vitamin D and the severity of COVID-19 in pregnant women. Maintaining adequate vitamin D levels may be useful as an approach to preventing an aggressive course of inflammation induced by this novel coronavirus in pregnant women.

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Section: Introductionmentioning

confidence: 99%

Evidence of the functions of vitamin D in pregnant women in COVID-19: a systematic review

Baptista

Filho

Pereira

et al. 2023

IJN

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“…Dilated cardiomyopathy can occur as a result of a deficiency. This significantly increases the morbidity and mortality in such neonates 9,10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…If the deficiency is not corrected early on, radiological changes such as rachitic rosary and craniotabes, decreased mineralization of bones, rib beading, metaphyseal band of relative lucency, mild cupping, or haziness of the distal end of the ulna or radius can be observed. [7][8][9][10] There are very few studies done on the ideal method of diagnosis of vitamin D deficiency in neonates. Hence, we performed this study to observe the diagnostic potential of cord vitamin D levels in term neonates a well as assessing the maternal factors influencing it.…”

Section: Introductionmentioning

confidence: 99%

Cord vitamin D levels in newborns and its clinical correlation

SWATHI ON,

ADARSH DHAVALESHWAR,

BELA VERMA

2023

Int. J. Front. Med. Surg. Res.

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Vitamin D levels in newborns mainly depend on maternal vitamin D levels and maternal-fetal transfer of Vitamin D and its metabolites during pregnancy. Babies born to mothers with marked Vitamin D deficiency may have neonatal Rickets. There are many factors determining the Vitamin D levels in mother, like skin pigmentation, duration of sunlight exposure, body mass index, degree of altitude, clothing, sunscreen use, weather, air pollution, season and time of the day. Mothers with light - colored skin require a lesser duration of exposure as compared to mothers with dark-colored skin. If left untreated, children can develop hypocalcemic seizures, growth failure, irritability, lethargy, respiratory infections, and allergies, tetany, and laryngospasm and even dilated cardiomyopathy. Hence we performed this study to evaluated the role of cord vitamin D levels. Methods this was a prospective observational study performed on term neonates weighing > 2.5 kg. Cord vitamin D was estimated at birth, and correlated with various maternal parameters such as anaemia, sun exposure, co-morbidities etc. Results: the mean cord vitamin D levels were low in those babies born to mothers with anaemia, lack of pre-natal supplementation of vitamin D and calcium, as well as less sun exposure. Conclusion: Cord vitamin D could be a marker of vitamin D deficiency in neonates born to mothers with risk factors like anaemia, lack of sun exposure and supplementation.

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“…In Sweden, a longitudinal study reported 37% of first-trimester pregnant women had 25(OH)D concentrations < 20 ng/mL [ 13 ], in comparison with 23% of Canadian women [ 14 ]. In Mexico, a previous cross-sectional study reported VDD among 61% of women in the third trimester, and 98% of their newborns had vitamin D deficiency [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D-Related Risk Factors for Maternal Morbidity and Mortality during Pregnancy: Systematic Review and Meta-Analysis

Morales-Suárez-Varela

Uçar

Soriano

et al. 2022

Nutrients

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Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] levels <20 ng/mL in serum) is a common health condition among pregnant women, especially in high-risk groups. Evidence has connected vitamin D levels with many health-related problems during pregnancy, including gestational diabetes and preeclampsia. Because of vitamin D’s effect on both mother and fetus, we systematically review the association between 25(OH)D level and its health effects. From a total of 143 studies, 43 came from PubMed, 4 from Cochrane, and 96 from EMBASE. After screening, we identified 38 studies as candidates for inclusion. Ultimately, we limited this review to 23 articles originating from 12 countries, written in English or Spanish, and conducted between 2010 and 2022. We conducted this review according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines and evaluated the quality and strength of the evidence by using the Navigation Guide Systematic Review Methodology (SING). These systematic reviews summarize findings that support vitamin D’s role in reducing risks of multiple outcomes and the possible contribution of adequate vitamin D levels to a healthy pregnancy.

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Vitamin D deficiency in Mexican mothers and their newborns

Cited by 4 publications

References 30 publications

Evidence of the functions of vitamin D in pregnant women in COVID-19: a systematic review

Evidence of the functions of vitamin D in pregnant women in COVID-19: a systematic review

Cord vitamin D levels in newborns and its clinical correlation

Vitamin D-Related Risk Factors for Maternal Morbidity and Mortality during Pregnancy: Systematic Review and Meta-Analysis

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