Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency

Dąbrowska-Leonik, Nel; Bernatowska, Ewa; Pac, Małgorzata; Filipiuk, Wiktor; Mulawka, Jan J.; Pietrucha, Barbara; Heropolitańska-Pliszka, Edyta; Bernat-Sitarz, Katarzyna; Wolska-Kuśnierz, Beata; Mikołuć, Bożena

doi:10.1016/j.advms.2017.08.001

Cited by 14 publications

(13 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,25(OH) 2 D blocked the proliferation of activated B-cells and stimulated their apoptosis. It also inhibited maturation of activated B-cells into plasma cells and memory cells that is consistent with the inhibitory action of VD on the secretion of IgM and IgG [8]. Several observational trials showed an inverse relationship between serum IgE and 25OHD levels, while others indicated a positive correlation [9].…”

Section: Role Of Vitamin D In Immune Regulation and Inflammatory Respsupporting

confidence: 68%

Vitamin D Deficiency and Diabetes Mellitus

Shymanskyi¹,

Lisakovska²,

Mazanova³

et al. 2020

Vitamin D Deficiency

View full text Add to dashboard Cite

Vitamin D (VD) is a molecule that can be synthesized directly in the humans' body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D-1,25(OH) 2 D. 1,25(OH) 2 D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells' functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.

show abstract

Section: Role Of Vitamin D In Immune Regulation and Inflammatory Respsupporting

confidence: 68%

Vitamin D Deficiency and Diabetes Mellitus

Shymanskyi¹,

Lisakovska²,

Mazanova³

et al. 2020

Vitamin D Deficiency

View full text Add to dashboard Cite

show abstract

“…This runs with Paulino et al (10) documented that in the group of children with IgG deficiencies, vitamin D concentrations were significantly lower than in other patients without IgG deficiencies, something that was also observed in patients with primary and secondary immunodeficiency. Also, Dąbrowska-Leonik et al (11) demonstrated that patients with reduced Ig G had statistically-significant lower vitamin D concentrations than children with normal concentrations of IgG and they found that IgG deficiency does not result from the synthesis-inhibiting effect of vitamin D. Moreover, they showed that vitamin D3 supplementation was needed in patients with reduced IgG levels, and also in the case of associated reduced IgA and IgM concentrations. On the other hand, Chen et al (12) found that vitamin D inhibits Ig production by inhibiting IL-2 receptor expression on B cells.…”

Section: Discussionmentioning

confidence: 99%

Serum Immunoglobulins in Children with Vitamin D Resistant Rickets

Amin

Kamal

Gaballah³

et al. 2019

Suez Canal University Medical Journal

View full text Add to dashboard Cite

Background: Vitamin D plays an immunoregulatory role in both the innate and adaptive immune systems. Rickets is a disorder that can develop due to a lack of vitamin D, calcium, or phosphate. Aim: The aim of this study was to assess serum immunoglobulins as one of the aspects of humoral immunity in children with vitamin D resistant rickets. Subjects and Methods: This casecontrol study was performed on 60 patients divided into Group (A):30 cases with vitamin D resistant rickets patients who were presented with rachitic manifestation who did not respond to therapeutic doses of the vitamin. Group (B):30 cases with untreated classic vitamin D deficiency rickets. Group (C): 30 healthy subjects as a control group. All subjects were subjected to detailed history taking including age, sex, weight, dietary history, medication history, and physical examination including vital signs, body weight, and head circumference. Laboratory investigations that included calcium, phosphorus, alkaline phosphatase, electrolytes, ESR, urine analysis, parathyroid hormone, vitamin D, and Immunoglobulin assay. Results: There is a significant decrease of IgA in vitamin D deficiency rickets and vitamin D resistant rickets than in controls (3.74 ± .867, 3.13 ± 1.72, 5.01 ± 1.61, respectively with P =0.012).There is a significant decrease of IgG in vitamin D deficiency rickets and a significant increase in vitamin D resistant rickets than in controls (523.5 ± 136.3, 751.25 ±163.5, 692.0 ± 186.4, respectively with P =0.009). There is no significant difference in IgM in the three studied groups. Conclusion: Patients with vitamin D deficiency have significantly lower IgG levels, while vitamin D resistant patients have significantly higher IgG levels. Whereas, both groups have lower IgA and normal IgM levels.

show abstract

“…Children presenting with delays in walking and teeth growing, irritability, seizure and frequent infections are common. These problems can lead to bone diseases such as rickets, autoimmune diseases such as multiple sclerosis, chronic urticaria, cardiovascular and respiratory diseases such as cardiomyopathies and asthma and also mental disorders such as schizophrenia, depression, autism and sleep disorders (1,2,(7)(8)(9)(12)(13)(14)(15)(16). deficiency in children under one year old by administering vitamin A + D drop and that vitamin D requirement increases with growth and ossification, it appears children older than one year need to be addressed (2,21).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Vitamin D Deficiency Among Children of 1 - 6 Years Old, Tehran, Iran

Babaniamansour

Hematyar

Babaniamansour

et al. 2019

J Kermanshah Univ Med Sci

View full text Add to dashboard Cite

Background: Vitamin D has an essential role in bone growth and metabolism. Currently, its role has been investigated in different diseases. It is high prevalence of vitamin D deficiency in the world, particularly in developing countries. Objectives: The aim of this study is to investigate the prevalence of vitamin D deficiency in children of 1 -6 years old and its relation with their age, sex and body mass index. Methods: This study was conducted in pediatric clinic of Javaheri Hospital in Tehran, from 2016 to 2017. The study population was children of 1 -6 years old presenting to the pediatric clinic for routine examination or treatment. The collected data included age, gender, height, weight, and serum 25-hydroxy vitamin D level. Results: Of the total population of 288 children, 47.2% were female and 52.8% were male. The prevalence of vitamin D deficiency was 51%, while 4.51% had severe deficiency (level of vitamin D < 10 ng/mL). The relation between the level of vitamin D and variables of gender, height, weight, and body mass index was not statistically significant. Nonetheless, the level of vitamin D had a statistically significant relation with age such that, serum level of 25(OH) vitamin D reduced by 3.47 ng/mL for every one year of age (P < 0.001). Conclusions:The prevalence of vitamin D deficiency is increasing with increasing age. Therefore, adoption of preventive and therapeutic measures is necessary to reduce its prevalence and side effects.One billion people worldwide suffer from vitamin D deficiency, with a high prevalence in the Middle East countries such as Iran, especially in children under 12, with a prevalence range of 25 to 85% (1,2,8,12,13,(17)(18)(19)(20).Since Iran has adopted the policy to prevent vitamin D

show abstract

Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency

Cited by 14 publications

References 49 publications

Vitamin D Deficiency and Diabetes Mellitus

Vitamin D Deficiency and Diabetes Mellitus

Serum Immunoglobulins in Children with Vitamin D Resistant Rickets

The Prevalence of Vitamin D Deficiency Among Children of 1 - 6 Years Old, Tehran, Iran

Contact Info

Product

Resources

About