Vitamin D deficiency in cancer patients and predictors for screening (D-ONC study)

Alkan, Ali; Köksoy, Elif Berna

doi:10.1016/j.currproblcancer.2018.12.008

Cited by 11 publications

(15 citation statements)

References 25 publications

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“…There are plausible mechanisms for the operation of vitamin D in decreasing tumor invasiveness and propensity to metastasize, and influencing immunomodulatory properties [ 37 ] that may contribute to reduced metastatic disease and fatal cancer [ 2 ]. Vitamin D deficiency prevalence is high in cancer patients [ 38 , 39 , 40 ] and some studies report vitamin D deficiency in more than 70% of cancer patients. According to Alkan, risk factors linked with vitamin D deficiency include female sex, low sunlight exposure, being under palliative care or adjuvant chemotherapy or history of gastrointestinal surgery [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency prevalence is high in cancer patients [ 38 , 39 , 40 ] and some studies report vitamin D deficiency in more than 70% of cancer patients. According to Alkan, risk factors linked with vitamin D deficiency include female sex, low sunlight exposure, being under palliative care or adjuvant chemotherapy or history of gastrointestinal surgery [ 40 ]. Moreover, the VDS dose may have been inadequate to sufficiently increase vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Supplementation and Cancer Mortality: Narrative Review of Observational Studies and Clinical Trials

Gnagnarella

Muzio

Caini³

et al. 2021

Nutrients

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Several studies have investigated the beneficial effects of vitamin D on survival of cancer patients. Overall evidence has been accumulating with contrasting results. This paper aims at narratively reviewing the existing articles examining the link between vitamin D supplementation and cancer mortality. We performed two distinct searches to identify observational (ObS) studies and randomized clinical trials (RCTs) of vitamin D supplementation (VDS) in cancer patients and cohorts of general population, which included cancer mortality as an outcome. Published reports were gathered until March 2021. We identified 25 papers published between 2003 and 2020, including n. 8 RCTs on cancer patients, n. 8 population RCTs and n. 9 ObS studies. There was some evidence that the use of VDS in cancer patients could improve cancer survival, but no significant effect was found in population RCTs. Some ObS studies reported evidence that VDS was associated with a longer survival among cancer patients, and only one study found an opposite effect. The findings do not allow conclusive answers. VDS may have the potential as treatment to improve survival in cancer patients, but further investigations are warranted. We strongly support investment in well-designed and sufficiently powered RCTs to fully evaluate this association.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation and Cancer Mortality: Narrative Review of Observational Studies and Clinical Trials

Gnagnarella

Muzio

Caini³

et al. 2021

Nutrients

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“…At least the analysis of seasons could exclude the seasonal bias. In our D-ONC study, we found VDD in 72.0% of 706 cancer patients [2]. And all those patients were also living in a hot climate with high sunlight exposure.…”

Section: To the Editormentioning

confidence: 69%

Vitamin D deficiency in oncology practice—more roads to cross

Alkan

Türkkan

Tanrıverdi

2019

Support Care Cancer

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“…Some experts now believe that low serum 25(OH)D is most likely an effect of chronic inflammation rather than the cause [ 36 , 38 ]; however, further studies are needed to answer this question [ 37 ]. Additionally, vitamin D deficiency is highly prevalent in patients with newly diagnosed cancer [ 39 , 40 , 41 ]. In order to maximize the beneficial effects of vitamin D for health, it is suggested to increase the intake of vitamin D and/or exposure of sunlight to maintain serum 25(OH)D at least at 30 ng/mL (75 nmol/L) and preferably at 40–60 ng/mL (100–150 nmol/L) [ 35 , 42 , 43 , 44 ].…”

Section: Vitamin D Sources Metabolism and Signalingmentioning

confidence: 99%

Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer

Wei

Wang

Zuo

et al. 2021

Cancers

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Pancreatic cancer has a dismal prognosis, while its incidence is increasing. This is attributed, in part, to a profound desmoplastic and immunosuppressive tumor microenvironment associated with this cancer and resistance to current available therapies. Novel and effective intervention strategies are urgently needed to improve the outcomes of patients with pancreatic cancer. Vitamin D has pleiotropic functions beyond calcium–phosphate homeostasis and has been extensively studied both in the laboratory and clinic as a potential preventive agent or adjunct to standard therapies. Accumulating evidence from ecological, observational, and randomized controlled trials suggests that vitamin D has beneficial effects on risk, survival, and mortality in pancreatic cancer, although controversies still exist. Recent advances in demonstrating the important functions of vitamin D/vitamin D receptor (VDR) signaling in the regulation of stromal reprogramming, the microbiome, and immune response and the emergence of checkpoint immunotherapy provide opportunities for using vitamin D or its analogues as an adjunct for pancreatic cancer intervention. Many challenges lie ahead before the benefits of vitamin D can be fully realized in pancreatic cancer. These challenges include the need for randomized controlled trials of vitamin D to assess its impact on the risk and survival of pancreatic cancer, optimizing the timing and dosage of vitamin D or its analogues as an adjunct for pancreatic cancer intervention and elucidating the specific role of vitamin D/VDR signaling in the different stages of pancreatic cancer. Nevertheless, vitamin D holds great promise for reducing risk and improving outcomes of this disease.

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Vitamin D deficiency in cancer patients and predictors for screening (D-ONC study)

Cited by 11 publications

References 25 publications

Vitamin D Supplementation and Cancer Mortality: Narrative Review of Observational Studies and Clinical Trials

Vitamin D Supplementation and Cancer Mortality: Narrative Review of Observational Studies and Clinical Trials

Vitamin D deficiency in oncology practice—more roads to cross

Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer

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