Vitamin D deficiency in adolescent pregnancy and obstetric outcomes

Öcal, Fatma Doğa; Aycan, Zehra; Dagdeviren, Gulsah; Kanbur, Nuray; Küçüközkan, Tuncay; Derman, Orhan

doi:10.1016/j.tjog.2019.09.008

Cited by 8 publications

(10 citation statements)

References 31 publications

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“…The occurrence of prenatal 25(OH)D deficiency is common among pregnant women [13], and this result is consistent with that of the current study. The vitamin D concentrations in all three groups were low, with an average value between 60.7 and 61.8 nmol/L.…”

Section: Discussionsupporting

confidence: 93%

Large retrospective cohort study of the association between maternal 25-hydroxyvitamin D status and birth weight of neonate

Che

et al. 2021

The Journal of Maternal-Fetal & Neonatal Medicine

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Background:The effect of maternal vitamin D status on the birth weight of offspring is controversial as the results are inconsistent between different populations. This large 2 retrospective cohort study aimed to assess the relationship between maternal vitamin D levels and birth weight of neonate. Methods: Serum samples were collected from 10,586 Chinese women in the 2 nd trimester of pregnancy, and the 25-hydroxyvitamin D [25(OH)D] level of the participants was assessed.Using the INTERGROWTH-21st standards, the offsprings were classified into three groups based on their gestational age and birth weight, which were as follows: small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). Results:The average maternal vitamin D concentration was 61.1 nmol/L. The 25(OH)D concentrations were <75.0, <50.0, and <25.0 nmol/L in 76.6%, 31.1%, and 1.6% of the participants, respectively. Approximately 6.4%, 86.4%, and 7.2% of women delivered SGA, AGA, and LGA infants, respectively. No significant differences were observed in vitamin D levels between the three groups (P = 0.562). With the increase in 25(OH)D levels, the risk of SGA and LGA tended to increase and decrease, respectively. However, the results were not precise. AGA was not affected by 25(OH)D levels. The results of the curve fitting and threshold effect analyses did not support the correlation between vitamin D levels and SGA orLGA. Based on the univariate prediction model and the model that adjusted for the risk factors, the area under the curve was extremely small. Thus, 25(OH)D level is not an effective predictor of SGA and LGA.Conclusions: Low maternal vitamin D levels were not associated with SGA or LGA.

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Section: Discussionsupporting

confidence: 93%

Large retrospective cohort study of the association between maternal 25-hydroxyvitamin D status and birth weight of neonate

Che

et al. 2021

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Additionally, 25-OH D vitamin levels were low (<20 ng/mL) on both COVID-19 (12.46) and control (18.76) groups. Considering the fact that vitamin D deficiency is common among pregnant women, we think it is not surprising that 25-OH vitamin D levels were also low in healthy pregnant women in control group [ [9] , [10] , [11] ]. Besides the incidence of COVID-19, our findings showed a significant correlation between 25-OH D vitamin level and the COVID-19 severity in pregnant women, and this is in line with the majority of the related literature [ 15 , [18] , [19] , [20] , [21] , [22] , [23] , [31] , [32] , [33] , [42] , [43] ].…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, the prevalence of vitamin D deficiency in pregnant women in our country was reported as 81.4-86%. [ 10 , 11 ]. Vitamin D has various effects during pregnancy such as placental implantation, angiogenesis, immune function, oxidative stress, endothelial function, inflammatory response, and glucose homeostasis [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study

Sınacı

Öcal

Yetiskin

et al. 2021

The Journal of Steroid Biochemistry and Molecular Biology

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“…Due to the high prevalence of VDD in adolescent Turkish girls especially during pregnancy and its negative outcomes on fetus and labor, Öcal and colleagues suggested that effective prophylaxis programs for VDD and/or fortification of foods with VD are essential to be implemented in all pregnant women especially during winter season [26] …”

Section: Discussionmentioning

confidence: 99%

Vitamin D status and healthy Egyptian adolescents

et al. 2021

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Vitamin D deficiency is a worldwide public health problem. Low vitamin D and its consequences among children and adolescents could be considered as one of the most important health-related problems. This study aimed to estimate the prevalence of vitamin D deficiency in healthy Egyptian adolescents and investigate factors associated with vitamin D status.A cross-sectional study was conducted on 572 school children (270 males and 302 females) aged 14 to 18 years, who were randomly selected from high schools in one governorate in Egypt. Data were collected through a self-administered questionnaire. Vitamin D level, serum calcium, phosphorus, alkaline phosphates were measured.Vitamin D deficiency was almost present in all the studied Egyptian healthy adolescents (99%), 94.8% had vitamin D deficiency and 4.2% had vitamin D insufficiency. Girls had a higher prevalence of vitamin D deficiency than boys. There was a significant association between lack of physical activity, sun exposure, and vitamin D deficiency.Vitamin D deficiency and insufficiency are highly prevalent. In sunny countries, the special pattern of conservative clothing and the lack of outdoor physical activity might be the underlying factors for the high prevalence in females. Vitamin D supplementation seems to be mandatory to halt the problem.

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Vitamin D deficiency in adolescent pregnancy and obstetric outcomes

Cited by 8 publications

References 31 publications

Large retrospective cohort study of the association between maternal 25-hydroxyvitamin D status and birth weight of neonate

Large retrospective cohort study of the association between maternal 25-hydroxyvitamin D status and birth weight of neonate

Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study

Vitamin D status and healthy Egyptian adolescents

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