Vitamin D deficiency in a psychiatric population and correlation between vitamin D and CRP

Faivre, S.; Roche, Nanette S.; Lacerre, F.; Dealberto, Marie-José

doi:10.1016/j.encep.2019.02.005

Cited by 3 publications

(5 citation statements)

References 37 publications

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“…Thus, it is unclear whether vitamin D deficiency in the psychiatric population is a consequence of mental illness or if it has a role in the pathogenesis. Since sunlight is an essential element for vitamin D synthesis, it is expected that inpatients with institutionalization, social isolation, or multidrug regimen will have lower levels of vitamin D [24].…”

Section: Discussionmentioning

confidence: 99%

“…Some data suggest that the psychiatric population has a higher rate of vitamin D deficiency than the general population [17,[23][24][25][26][27][28][29][30][31]. Patients from a psychiatric ward in Serbia have been included in a cross-sectional design study, and a significant number of patients had a lower vitamin D level than expected [30].…”

Section: Psychiatric Diseases and Vitamin Dmentioning

confidence: 99%

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Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

Ciobanu,

Petrescu,

Anghele

et al. 2023

Medicina

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In the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, the potential function in the nervous system and the link between different psychiatric disorders and vitamin D deficiency have been revealed. The discovery of vitamin D receptors in multiple brain structures, like the hippocampus, led to the hypothesis that vitamin D deficiency could be responsible for treatment resistance in psychiatric diseases. The aim of this study was to analyze the current knowledge in the literature regarding vitamin D deficiency among individuals afflicted with psychiatric disorders and assess the potential therapeutic benefits of vitamin D supplementation. A systematic search was conducted on the PubMed database for articles published in the last five years (2016–2022) in English, focusing on human subjects. Results show that vitamin D deficiency has implications for numerous psychiatric disorders, affecting mood and behavior through its influence on neurotransmitter release, neurotrophic factors, and neuroprotection. It also plays a role in modulating inflammation, which is often elevated in psychiatric disorders. In conclusion, vitamin D deficiency is prevalent and has far-reaching implications for mental health. This review underscores the importance of exploring the therapeutic potential of vitamin D supplementation in individuals with psychiatric disorders and highlights the need for further research in this complex field.

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Section: Discussionmentioning

confidence: 99%

Section: Psychiatric Diseases and Vitamin Dmentioning

confidence: 99%

Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

Ciobanu,

Petrescu,

Anghele

et al. 2023

Medicina

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“…Another molecule linked to the immune system function is vitamin D. Besides the roles played in calcium homeostasis, vitamin D has important immune functions ( 157 ). Low levels of vitamin D were reported in association with increased levels of proinflammatory cytokines in various disorders such as cancer and psychiatric conditions ( 158 – 162 ). Specifically, vitamin D metabolites have a regulatory repressive effect on IL-8 promoter activation, through vitamin D receptor (VDR) stimulation ( 163 ).…”

Section: Immune System Involvement In Asdmentioning

confidence: 99%

Re-emerging concepts of immune dysregulation in autism spectrum disorders

et al. 2022

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Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by communication and social interaction deficits, and by restricted interests and stereotyped, repetitive behavior patterns. ASD has a strong genetic component and a complex architecture characterized by the interplay of rare and common genetic variants. Recently, increasing evidence suggest a significant contribution of immune system dysregulation in ASD. The present paper reviews the latest updates regarding the altered immune landscape of this complex disorder highlighting areas with potential for biomarkers discovery as well as personalization of therapeutic approaches. Cross-talk between the central nervous system and immune system has long been envisaged and recent evidence brings insights into the pathways connecting the brain to the immune system. Disturbance of cytokine levels plays an important role in the establishment of a neuroinflammatory milieu in ASD. Several other immune molecules involved in antigen presentation and inflammatory cellular phenotypes are also at play in ASD. Maternal immune activation, the presence of brain-reactive antibodies and autoimmunity are other potential prenatal and postnatal contributors to ASD pathophysiology. The molecular players involved in oxidative-stress response and mitochondrial system function, are discussed as contributors to the pro-inflammatory pattern. The gastrointestinal inflammation pathways proposed to play a role in ASD are also discussed. Moreover, the body of evidence regarding some of the genetic factors linked to the immune system dysregulation is reviewed and discussed. Last, but not least, the epigenetic traits and their interactions with the immune system are reviewed as an expanding field in ASD research. Understanding the immune-mediated pathways that influence brain development and function, metabolism, and intestinal homeostasis, may lead to the identification of robust diagnostic or predictive biomarkers for ASD individuals. Thus, novel therapeutic approaches could be developed, ultimately aiming to improve their quality of life.

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“…Three observational studies have been published since the most recent meta-analysis. [96][97][98] In these studies, the relationship between depression and VIT-D deficiency was less clear. One study failed to find a significant difference in participants with non-psychotic depression and controls.…”

Section: Proof Of Principle Laboratory Findingsmentioning

confidence: 99%

“…There have been six observational studies published since the most recent meta-analysis. 96 , 97 , 104 – 107 Four studies found a low VIT-D concentration in individuals with psychosis or schizophrenia, 96 , 105 – 107 two of which concerned first episode psychosis. 105 , 106 Two studies failed to find such an association.…”

Section: Vitamin D and Serious Mental Disordersmentioning

confidence: 99%

Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective

Werneke

Gaughran

Taylor

2021

Therapeutic Advances in Psychopharmacology

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Individuals with serious mental disorders (SMD) may have a higher risk of vitamin D (VIT-D) deficiency. They also experience higher mortality because of coronavirus disease 2019 (COVID-19) infection. Therefore, we have conducted a comprehensive review to examine the significance of VIT-D for public health and public mental health during the ongoing COVID-19 pandemic. This review had three specific aims, from a global perspective to (a) create a profile of VIT-D and review the epidemiology of VIT-D deficiency, (b) explore VIT-D deficiency as risk factor for SMD and COVID-19 infections and (c) examine the effectiveness of VIT-D supplementation for both conditions. We found that, in terms of SMD, the evidence from laboratory and observational studies points towards some association between VIT-D deficiency and depression or schizophrenia. Mendelian randomisation studies, however, suggest no, or reverse, causality. The evidence from intervention studies is conflicting. Concerning COVID-19 infection, on proof of principle, VIT-D could provide a plausible defence against the infection itself and against an adverse clinical course. But data from observational studies and the first preliminary intervention studies remain conflicting, with stronger evidence that VIT-D may mitigate the clinical course of COVID-19 infection rather than the risk of infection in the first place. From a public health and public mental health point of view, based on the currently limited knowledge, for individuals with SMD, the benefits of VIT-D optimisation through supplementation seem to outweigh the risks. VIT-D supplementation, however, should not substitute for vaccination or medical care for COVID-19 infection.

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Vitamin D deficiency in a psychiatric population and correlation between vitamin D and CRP

Cited by 3 publications

References 37 publications

Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

Re-emerging concepts of immune dysregulation in autism spectrum disorders

Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective

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