Vitamin D deficiency during late pregnancy mediates placenta-associated complications

Raia-Barjat, Tiphaïne; Sarkis, Camille; Rançon, F; Thibaudin, Lise; Gris, Jean-Christophe; Alfaidy, Nadia; Chauleur, Céline

doi:10.1038/s41598-021-00250-5

Cited by 13 publications

(24 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the majority of studies emphasized the link between vitamin D insufficiency and preeclampsia, which seemed to be most prominent between 32 and 36 weeks of pregnancy in high-risk groups [ 39 ]. Lastly, an important evidence according to the most recent meta-analysis suggests that insufficient maternal 25(OH)D serum levels may raise the risk of preeclampsia [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study

et al. 2022

View full text Add to dashboard Cite

Preeclampsia is a pregnancy-specific illness that is hypothesized to occur due to vitamin D deficiency during pregnancy. Therefore, vitamin D supplementation in early pregnancy should be explored for preventing preeclampsia and promoting neonatal well-being. The present study follows a case-control analysis that aims to determine the effect of vitamin D supplements on reducing the probability of recurrent preeclampsia. We identified 59 patients for the control group without vitamin D supplementation during pregnancy, while 139 patients were included in the cases group of pregnant women with a history of preeclampsia who confirmed taking daily vitamin D supplements in either 2000 UI or 4000 UI until the 36th week of pregnancy. There were 61 (80.3%) patients with a normal serum vitamin D level measured at 32 weeks in the pregnant women who took a daily dose of 4000 UI vitamin D and 43 (68.3%) in those who took a 2000 UI dose of vitamin D, compared to just 32 (54.2%) in those who did not take vitamin D at all. Regarding the blood pressure of pregnant women measured at 32 weeks, it was observed that 20.3% were hypertensive in the no supplementation group, compared to only 11.1% and 6.6% in those who were taking vitamin D during pregnancy (p-value = 0.049). Serum vitamin D levels at 32 weeks were measured at an average value of 23.9 ng/mL, compared with 28.4 ng/mL in the group taking a 2000 UI daily dose and 33.6 in those who supplemented with 4000 UI daily (p-value < 0.001). Proteinuria was identified more often in the group at risk for preeclampsia who did not take vitamin D supplements, while systolic blood pressure (p-value = 0.036) as well as diastolic blood pressure (p-value = 0.012), were all identified to have significantly higher values in the pregnant women with a history of preeclampsia that did not take vitamin D during the current pregnancy. The significant risk factors for preeclampsia development in pregnant patients at risk are: insufficient vitamin D serum levels (<20 ng/mL), OR = 2.52; no vitamin D supplementation, OR = 1.46; more than two pregnancies, OR = 1.89; gestational diabetes mellitus, OR = 1.66; and cardiovascular comorbidities, OR = 2.18. These findings imply that vitamin D has a role in the preservation of placental function and, therefore, in the prevention of the development of late preeclampsia. Pregnant mothers who supplemented their diets with vitamin D were protected against preeclampsia recurrence. Vitamin D supplementation during pregnancy may aid in the prevention of gestational hypertension and preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 99%

The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Vitamin D is a pre-hormone, that can also be endogenously produced by the skin when exposed to UV-B. Vitamin D plays an important role in preventing bone diseases and improving calcium metabolism [ 208 ]. Recently, vitamin D has also been shown to regulate the expression of signature developmental and angiogenic genes in the placenta [ 209 – 211 ].…”

Section: Micronutrientsmentioning

confidence: 99%

Dietary supplements and vascular function in hypertensive disorders of pregnancy

Man

Zhou

Xia

et al. 2023

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

Hypertensive disorders of pregnancy are complications that can lead to maternal and infant mortality and morbidity. Hypertensive disorders of pregnancy are generally defined as hypertension and may be accompanied by other end organ damages including proteinuria, maternal organ disturbances including renal insufficiency, neurological complications, thrombocytopenia, impaired liver function, or uteroplacental dysfunction such as fetal growth restriction and stillbirth. Although the causes of these hypertensive disorders of pregnancy are multifactorial and elusive, they seem to share some common vascular-related mechanisms, including diseased spiral arteries, placental ischemia, and endothelial dysfunction. Recently, preeclampsia is being considered as a vascular disorder. Unfortunately, due to the complex etiology of preeclampsia and safety concerns on drug usage during pregnancy, there is still no effective pharmacological treatments available for preeclampsia yet. An emerging area of interest in this research field is the potential beneficial effects of dietary intervention on reducing the risk of preeclampsia. Recent studies have been focused on the association between deficiencies or excesses of some nutrients and complications during pregnancy, fetal growth and development, and later risk of cardiovascular and metabolic diseases in the offspring. In this review, we discuss the involvement of placental vascular dysfunction in preeclampsia. We summarize the current understanding of the association between abnormal placentation and preeclampsia in a vascular perspective. Finally, we evaluate several studied dietary supplementations to prevent and reduce the risk of preeclampsia, targeting placental vascular development and function, leading to improved pregnancy and postnatal outcomes.

show abstract

“…Part three: -Consisted of sixteen questions (most of them were open ended questions) in Arabic language used to assess the physical examination and laboratory investigation of the pregnant women which included blood pressure measurement, calculation of pre-pregnancy body mass index (BMI), signs of edema, urine analysis, complete blood count, liver and kidney function tests. Tool (II): Measurement of serum 25(OH) vitamin D level by using an Enzyme Linked-Immunosorbent Assay (ELISA) for the quantitative measurement of serum 25-OH vitamin D and adopted from (Raia- Barjat et al, 2021).…”

Section: Tools Of Data Collectionmentioning

confidence: 99%

relationship between vitamin D deficiency and preeclampsia

Negm¹,

Abd-Elmoneim²,

El-Sayed³

2022

ijhs

View full text Add to dashboard Cite

Background: Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. Vitamin D deficiency has been associated with several adverse pregnancy outcomes. Aim: The current study aimed to determine the relationship between vitamin D deficiency and preeclampsia. Research Design: A case control design. Setting: The study was conducted at the antenatal clinic at Al zahraa hospital – Al-Azhar University, Cairo, Egypt. Sample: Purposive sample (120 pregnant women), was divided into study group (n=60) and control group (n=60). Tools: Two tools for data collection. First tool: A structured interviewing questionnaire which used to assess demographic data, obstetrical history, family history, physical examination to diagnose preeclampsia and laboratory investigation to confirm the diagnosis. Second tool: Serum vitamin D levels of both groups were measured by using an Enzyme Linked Immunosorbent Assay (ELISA) technique. Result: Significant lower mean vitamin D of study group compared to control group with highly statistical significant difference between both groups. In addition, there were 3-fold increased odds of developing preeclampsia in pregnant women who had vitamin D deficiency (<20 ng/ml). Also, observed that when vitamin D level decreases, the severity of preeclampsia increases.

show abstract

Vitamin D deficiency during late pregnancy mediates placenta-associated complications

Cited by 13 publications

References 42 publications

The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study

The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study

Dietary supplements and vascular function in hypertensive disorders of pregnancy

relationship between vitamin D deficiency and preeclampsia

Contact Info

Product

Resources

About