Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies

Zhao, Jingbo; Wang, Haipeng; Zhang, Zhongwen; Zhou, Xiaojun; Yao, Jinming; Zhang, Rui; Liao, Lin; Dong, Jianjun

doi:10.1016/j.nut.2018.04.015

Cited by 69 publications

(66 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies performed on colorectal [18,19,20], breast [20,21], prostate [20,21], ovarian [20], lung [20,22], pancreatic [20], neuroblastoma [20], and overall cancer risk [23] did not find an association with DHCR7 rs12785878. However, the association of these cancers with vitamin D levels is more controversial than for thyroid cancer [4,5], and this might explain the lack of an association with DHCR7 . No other study of this SNP in thyroid cancer has so far been reported.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of thyroid cancer remains largely unknown, but individual susceptibility to thyroid cancer is likely to be influenced by the combined effect of the environment and multiple low-penetrance to moderate-penetrance genes [2,3]. Several studies have shown that serum levels of 25-hydroxyvitamin D are lower in patients with thyroid cancer [4,5]. This is in agreement with the growing body of evidence for a role of vitamin D in regulating cell proliferation and differentiation [6,7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer

Carvalho

Gonçalves

Almeida

et al. 2019

Genes

View full text Add to dashboard Cite

Vitamin D is mostly known for its role in bone and calcium metabolism. However, studies have suggested that it also has inhibitory effects on tumor development and progression. Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. The aim of this case-control study was to determine the effect of these variants in the vitamin D pathway on the susceptibility to thyroid cancer. Five hundred patients with differentiated thyroid cancer and 500 controls were genotyped for the DHCR7 rs12785878, CYP2R1 rs2060793, and CYP24A1 rs6013897 variants. Genotype and allele frequencies were compared between patients and controls. The DHCR7 rs12785878 minor allele was associated with thyroid cancer under an additive (OR 1.38, 95% CI 1.15–1.65, p = 0.0004) and codominant (OR 1.88, 95% CI 1.30–2.74, p = 0.0021) model. These findings suggest that DHCR7 polymorphisms may be associated with an increased risk of thyroid cancer due to an effect of this gene on circulating vitamin D levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer

Carvalho

Gonçalves

Almeida

et al. 2019

Genes

View full text Add to dashboard Cite

show abstract

“…Vitamin D has attracted increasing attention in recent decades. It not only regulates calcium homeostasis and bone health, 1 but also relates to many chronic diseases such as metabolic syndrome (MetS), 2 type 2 diabetes mellitus (T2DM), 3 cardiovascular disease, 4 cancer, 5 and dementia. 6 Vitamin D deficiency is generally defined as having a serum 25 hydroxyvitamin D [25(OH) D] level <20 ng/mL (50 nmol/L), and severe deficiency is defined as 25(OH) D <10 ng/mL (25 nmol/L).…”

Section: Introductionmentioning

confidence: 99%

<p>The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus</p>

Zhao

Zhen

Wang

et al. 2020

DMSO

View full text Add to dashboard Cite

The aims of this study were to determine the relationship between 25hydroxyvitamin D [25(OH) D] and glycated hemoglobin (HbA1c) levels in male and female patients with type 2 diabetes mellitus (T2DM). Patients and Methods: The participants were adults diagnosed with T2DM recruited from Hebei General Hospital. Patient information and information regarding blood indicators were collected. The subjects were divided into no vitamin D deficiency group [25(OH) D >20 ng/ mL] and vitamin D deficiency group [25(OH) D <20 ng/mL], and these groups were then further subdivided into male-only or female-only subgroups. And then, the subjects were divided into male group and female group in different 25(OH) D levels. Results: HbA1c levels in the vitamin D deficiency group were significantly higher than those in the no vitamin D deficiency group for all subjects. The same was true for female patients but not for male patients. There was no difference in HbA1c levels between male and female patients with T2DM, regardless of 25(OH) D deficiency. A negative correlation existed between 25(OH) D and HbA1c in all subjects, as well as in the male-only and female-only subgroups. Vitamin D deficiency was associated with high HbA1c levels before and after adjusting for confounding factors in all participants and in the female-only subgroup, but not in the male-only subgroup. Conclusion: This study confirmed that vitamin D deficiency was related with high HbA1c levels in patients with T2DM, and this relationship differs between female and male patients.

show abstract

“…But in 2018, Zhang et al found that the content of 1,25 (OH) 2 D 3 in the serum of patients with PTC is significantly lower than that of healthy people, so maybe 1,25 (OH) 2 D 3 can become a potential diagnostic marker for PTC. 27 Hu's 28 and Zhao's 29 further studies suggest that 25 (OH) D 3 and vitamin D binding protein may even be protective factors for thyroid cancer and vitamin D deficiency may be a risk factor for thyroid cancer.…”

Section: Markers Related To Thyroid Functionmentioning

confidence: 99%

<p>The Blood Biomarkers of Thyroid Cancer</p>

Wang¹,

Chang²,

Jia³

et al. 2020

CMAR

View full text Add to dashboard Cite

Introduction: With the gradual increase in the incidence of thyroid cancer, people's attention to thyroid cancer has also gradually increased. Although the prognosis of thyroid cancer is rather mild compared to other cancers, it will still bring a heavy psychological burden on people who have been diagnosed. At present, the diagnosis of thyroid cancer mainly depends on ultrasound and percutaneous fine needle aspiration (pFNA). Due to the unsatisfactory accuracy of the diagnosis methods we use now, there are still some thyroid nodules that cannot be clearly diagnosed before surgery. Methods: In this article, we have searched for relevant research on blood markers of thyroid cancer in the past five years and categoried them into four groups. Discussion: Though we have not found a biomarker which can diagnose thyroid cancer both sensitively and specifically, we do found many substances that are related to it, and have the potential to recognize it and help the diagnosis. And perhaps combined models can do it better.

show abstract

Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies

Cited by 69 publications

References 33 publications

Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer

Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer

<p>The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus</p>

<p>The Blood Biomarkers of Thyroid Cancer</p>

Contact Info

Product

Resources

About