Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia

Zhang, Weibing; Zheng, Xiaodong; Wang, Yongzhi; Xiao, He

doi:10.1016/j.urology.2016.03.070

Cited by 23 publications

(31 citation statements)

References 30 publications

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“…Vitamin D seasonality is well documented and our results are in agreement with reported data for significantly higher 25OHD levels in summer and fall (warm season) vs lower 25OHD values in spring and winter (cold season) (28,29). The data regarding testosterone seasonal variations are scarce and controversial.…”

Section: Discussionsupporting

confidence: 92%

“…Surprisingly, lower median 25OHD values (37.37nmol/L) for the peak season for vitamin D synthesis were reported by Zhang et al for a cohort of 322 men aged 60 to 75 years from South China. More than 71% of their studied patients were vitamin D deficient and only 6.6% fall in the range over 75nmol/L (28).…”

Section: Discussionmentioning

confidence: 91%

“…Although the data concerning the link between PSA and 25OHD levels are very scarce in the literature, Zhang et al established no direct association between serum PSA and 25OHD in patients with and without vitamin D deficiency. They reported strong association between the presence of vitamin D deficiency and BPH, suggesting that vitamin D deficiency may be a marker of BPH (28).…”

Section: Discussionmentioning

confidence: 99%

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Is vitamin D associated with testosterone in benign prostate hyperplasia?

Roussev

Gerova

Kosev

et al. 2017

SSM

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Is vitamin D associated with testosterone in benign prostate hyperplasia?

Roussev

Gerova

Kosev

et al. 2017

SSM

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“…Five articles (Barassi et al, 2014;Caretta et al, 2016;Krysiak et al, 2018;Sudarevic et al, 2017;Zhang et al, 2016) with data compar- …”

Section: Iief-5 Scores In Subjects Without Vitamin D Deficiency Vermentioning

confidence: 99%

“…Of the remaining 15 articles, 8 were excluded; thus, the remaining 7 studies(Barassi, Pezzilli, Colpi, Corsi Romanelli, & Melzi d'Eril, 2014;Basat et al, 2018;Caretta et al, 2016;Farag et al, 2016;Krysiak et al, 2018; Sudarevic et al, 2017;Zhang, Zheng, Wang, & Xiao, 2016) were qualified for our meta-analysis. Of the remaining 15 articles, 8 were excluded; thus, the remaining 7 studies(Barassi, Pezzilli, Colpi, Corsi Romanelli, & Melzi d'Eril, 2014;Basat et al, 2018;Caretta et al, 2016;Farag et al, 2016;Krysiak et al, 2018; Sudarevic et al, 2017;Zhang, Zheng, Wang, & Xiao, 2016) were qualified for our meta-analysis.…”

mentioning

confidence: 99%

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

2018

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Suboptimal levels of serum vitamin D levels have been implied to be associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). The present systematic review and meta-analysis was performed to evaluate the vitamin D levels in subjects with ED compared to controls and the 5-item version of the international index of erectile function (IIEF-5) score in subjects with vitamin D deficiency compared to those without vitamin D deficiency in order to elucidate the role of vitamin D in the pathogenesis of ED. Studies evaluating the possible association between vitamin D levels and ED were initially screened and thus included following electronic literature search of database Cochrane Library, PUBMED, EMBASE and MEDLINE. Essential article information including outcome measures was extracted from the qualified studies by two independent authors, and STATA 12.0 software was used conducted the meta-analysis. Subgroup analyses were conducted by vitamin D detection methods and sample size. The standard mean difference (SMD) as well as the 95% confidence intervals (95% CIs) was applied to estimate the outcome measures. A total of seven articles were included in our meta-analysis with a total of 4,132 subjects. Pooled estimate was in favour of increased vitamin D levels in subjects without ED with a SMD of 3.027 ng/ml, 95%CI 2.290-3.314, p = 0.000. However, subgroup analysis showed an opposite trend, after one study with a sample size over 1,000 that could possibly influence the weight balance was excluded, with a SMD of 0.267, 95%CI −0.052 to 0.585, p = 0.101. We also identified about 0.320 higher in IIEF-5 score (95%CI = 0.146-0.494, p = 0.000) in subjects without vitamin D deficiency versus with vitamin D deficiency. Nevertheless, subgroup analysis based on vitamin D detection methods obtained differential results (radioimmunoassay subgroup, SMD(95%CI) = 0.573 (0.275-0.870), p = 0.000; immunoassay subgroup, SMD(95%CI) = 0.189 (−0.025 to 0.404), p = 0.084). In conclusion, results from the present meta-analysis did not provide a strong relationship between vitamin D and the risk of ED. However, the results should be interpreted with caution and more high quality studies are warranted. K E Y W O R D S5-item version of the international index of erection function, erectile dysfunction, metaanalysis of VD and ED, meta-analysis, vitamin D

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Conclusions and recommendations

Stoddard¹,

Chughtai²

2021

Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Dysfunction and Benign Prostatic

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Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia

Cited by 23 publications

References 30 publications

Is vitamin D associated with testosterone in benign prostate hyperplasia?

Is vitamin D associated with testosterone in benign prostate hyperplasia?

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

Conclusions and recommendations

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