Vitamin D deficiency as a cause of chronic pain in the palliative medicine clinic: Two case reports

Whitehurst, Jane; Reid, Colette

doi:10.1177/0269216313511142

Cited by 16 publications

(16 citation statements)

References 9 publications

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“…Without any doubt, avoiding falls and (spontaneous) fractures [8] even in palliative patient is meaningful. Vit D insufficiency creates secondary hyperparathyroidism with painful myopathy [9,10], muscle weakness, atrophy and acute arthritis due to chondrocalcinosis [11]. Quality of life is diminished, together with enhancing chronic pain [12].…”

Section: Discussionmentioning

confidence: 99%

“…1 represents the supplementation ratios for each nursing home and at each measurement. We compared the baseline vitamin D supplementation ratio of the twelve first participating NH's [1][2][3][4][5][6][7][8][9][10][11][12], called ''naive NH's'', with the five other NH's [13][14][15][16][17] that involved later in the study, called ''knowing NH's'' because of the gathered knowledge about the first results. The ''knowing NH's'' had a significant higher supplementation ratio than the ''naive NH's'' (64.7% AE 19.0 versus 26.0% AE 12.8; P < 0.001), visually represented by the black lines on Fig.…”

Section: Supplementation Ratiosmentioning

confidence: 99%

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Generalized vitamin D supplementation in nursing homes: Mission (im)possible?

Baeyens

Dekoninck

Desmet

et al. 2015

European Geriatric Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Supplementation Ratiosmentioning

confidence: 99%

Generalized vitamin D supplementation in nursing homes: Mission (im)possible?

Baeyens

Dekoninck

Desmet

et al. 2015

European Geriatric Medicine

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“…Moreover, a recent case report indicated that patient suffering with abdominal pain due to cervical cancer-related treatment was improved after vitamin D replacement therapy [136].…”

Section: Vitamin D and Cervical Cancer Riskmentioning

confidence: 99%

Vitamin D and Female Reproduction

Elhusseini¹,

Lizneva²,

Gavrilova-Jordan³

et al. 2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D deficiency has an impact on the reproduction of more than 40% of reproductive age women globally. Fibroids are more common among African-American females owing to their decreased milk consumption and reduced absorption of ultraviolet rays, supporting the relation between vitamin D deficiency and fibroid development. Vitamin D has an inhibitory effect on leiomyoma cells by suppression of proliferation cell nuclear antigen (PCNA), BCL-2, BCL-w, CDK1, and catechol-Omethyltransferase (COMT) protein levels. A growing evidence support the relationship between vitamin D deficiency and endometriosis through overexpression of vitamin D recseptor (VDR) and α-hydroxylase enzyme, however, it is still unclear if the endometriosis patients could benefit from vitamin D supplementation. Effect of vitamin D supplementation on the metabolic outcomes of polycystic ovary (PCO) has been studied and reveled that it is negatively correlated with fasting glucose, fasting insulin, triglycerides, C-reactive protein, free androgen index, and Dehydroepiandrosterone (DHEAS) and positively associated with quantitative insulin sensitivity check index (QUICKI), high density lipoprotein cholesterol (HDL-C), and sexual hormone binding globulin (SHBG), whereas its impact on the ovarian function is still unclear. Vitamin D deficiency may worse the obstetrical outcomes, including preeclampsia, gestational diabetes, low birth weight, increased cesarean section rate, neonatal asthma, seizures, and preterm labor. The relationship between serum levels of 25-hydroxy-vitamin D (25(OH) D) and pregnancy rates in ART is still debatable, with the need to conduct more clinical trials toward it. The in vitro antiproliferative and prodifferentiative effect of vitamin D might find a role in control of hyperplastic overactive bladder. Several studies support that vitamin D deficiency constitutes a risk factor for development of many types of cancer such as breast, ovarian, and colorectal.

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“…21,22 A recent case series reported treatment with vitamin D in the palliative medicine clinic where patients with chronic cancer pain refractory to conventional therapy showed a favourable response. 23 Surgical incision releases inflammatory mediators that reduce the pain threshold at the injury site and in the surrounding uninjured tissue. The combination of vitamin D deficiency and surgical incision may thus be especially deleterious.…”

Section: Résumémentioning

confidence: 99%

Low serum vitamin D levels are not associated with increased postoperative pain and opioid requirements: a historical cohort study

Bose

Khanna

You

et al. 2015

Can J Anesth/J Can Anesth

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Purpose Vitamin D deficiency has been associated with chronic non-specific musculoskeletal pain syndromes; however, studies are lacking with respect to its relationship with postoperative pain. We tested the hypothesis that a lower preoperative vitamin D level is associated with increased postoperative pain and/or opioid consumption in morbidly obese patients who had laparoscopic bariatric surgery.

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Vitamin D deficiency as a cause of chronic pain in the palliative medicine clinic: Two case reports

Cited by 16 publications

References 9 publications

Generalized vitamin D supplementation in nursing homes: Mission (im)possible?

Generalized vitamin D supplementation in nursing homes: Mission (im)possible?

Vitamin D and Female Reproduction

Low serum vitamin D levels are not associated with increased postoperative pain and opioid requirements: a historical cohort study

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