Vitamin D Deficiency and Supplementation and Relation to Cardiovascular Health

Vacek, James L.; Vanga, Subba Reddy; Good, Mathew; Lai, Sue Min; Lakkireddy, Dhanunjaya; Howard, Patricia A.

doi:10.1016/j.amjcard.2011.09.020

Cited by 185 publications

(146 citation statements)

References 24 publications

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“…Also in children, the association between vitamin D and cardiac morbidity seems to be present -as seen in the NHANES study where vitamin D deficiency was associated with hypertension, low HDL-cholesterol levels and elevated PTH levels (39). Another possible cardio-protective effect of vitamin D may be via lipid regulation, as the association between vitamin D deficiency and a less favourable lipid profile has been reported earlier (1,2,11,13,41). The positive correlation between 25(OH)D and HDL in postmenopausal women also seen in DOPS has previously been investigated and the subclass of large HDL was accounting for the difference (42).…”

Section: Discussionmentioning

confidence: 83%

“…Also in patients with type 2 diabetes and vitamin D deficiency, vitamin D treatment improved endothelial function (37). This may, partly, account for the association between vitamin D deficiency and hypertension (1,38,39).…”

Section: Discussionmentioning

confidence: 99%

“…The theory of a relationship between vitamin D and cardiovascular disease (CVD) and mortality is not new (2,3,4,5,6,7,8). The main dispute remains whether vitamin D is just a marker for a worse prognosis (9,10) potentially explained by other factors, as vitamin D deficiency has also been associated with obesity (1, 2, 11), smoking (2), ageing (1,12,13) and less physical activity (2,11). Though the major source of vitamin D is dermal production triggered by the sun (3,14), vitamin D is also ingested and could thus be a marker of general diet composition.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a large observational study found vitamin D deficiency to be associated with an increased risk of coronary artery disease, diabetes, cardiomyopathy, hypertension and all-cause death (1). The theory of a relationship between vitamin D and cardiovascular disease (CVD) and mortality is not new (2,3,4,5,6,7,8).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Schierbeck

Rejnmark

Tofteng

et al. 2012

European Journal of Endocrinology

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Objective: To investigate the relationship between vitamin D status in healthy women and cardiovascular outcome. Design and methods : Between 1990: Between and 1993: Between , 2016 healthy, recently postmenopausal women were enrolled in the Danish Osteoporosis Prevention Study. Serum levels of 25-hydroxyvitamin D (25(OH)D, nmol/l) were measured at baseline. Participants were followed for 16 years. The primary end point was a combination of death, heart failure, myocardial infarction (MI) and stroke. Vitamin D deficiency was defined as serum 25(OH)D!50 nmol/l. The primary end point was adjusted for other risk factors of adverse cardiovascular events (age, smoking, blood pressure, hip-waist ratio, education and family history of MI).

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Schierbeck

Rejnmark

Tofteng

et al. 2012

European Journal of Endocrinology

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“…Supplementing these patients was significantly associated with better survival. 15 Interventional studies like these are encouraging, but many questions remain regarding dosing and optimal levels, as well as the issue of concomitant calcium supplementation (which is somewhat contentious at present). 15 …”

Section: Cardiovascular Healthmentioning

confidence: 99%

An interesting D-lemma: what is all the excitement about vitamin D?

Conradie

Ascott-Evans

2013

South African Family Practice

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There has been a dramatic interest in the importance of vitamin D, "the sunshine vitamin", in the past few years with regard to its impact on various aspects of health and disease. Research into well-known skeletal effects, as well as extra-skeletal effects, has been overwhelming. At times it has been difficult to make informed clinical decisions regarding replacement, if needed at all. This article aims to provide the family practitioner with a summary of the most important clinical effects of vitamin D, as well as give guidelines on testing for possible deficiency and consideration of replacement thereof.Peer reviewed.

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More than metabolic: Considering the broader paleoepidemiological impact of vitamin D deficiency in bioarchaeology

Snoddy

Buckley

Halcrow

2016

American J Phys Anthropol

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Vitamin D deficiency has traditionally been viewed as a metabolic bone disease by bioarchaeologists and considered primarily in terms of the development of specific musculoskeletal changes used for diagnosis in paleopathological research. These skeletal manifestations are usually interpreted as representing general ill-health. Clinical research shows that vitamin D is also integral to a number of extra-skeletal physiological processes including immunoregulation, blood pressure homeostasis, cell division, and programmed cell death. Vitamin D deficiency and sub-clinical insufficiency are thought to be risk factors for infectious and autoimmune diseases, as well as certain cancers and cardiovascular diseases. Epidemiological work indicates that the skeletal manifestations of vitamin D deficiency represent the extreme end of a spectrum of morbidity associated with negative health outcomes, including increased risk for secondary tuberculosis. This article provides a review of clinical research on the extra-skeletal roles of vitamin D and the pathological consequences of poor vitamin D status. Additionally, it presents an interpretive model for bioarchaeological analyses of rickets and osteomalacia for consideration of the whole-body impact of poor vitamin D nutriture and possible comorbidities that may have affected the wider population. Am J Phys Anthropol 160:183-196, 2016. © 2016 Wiley Periodicals, Inc.

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Vitamin D Deficiency and Supplementation and Relation to Cardiovascular Health

Cited by 185 publications

References 24 publications

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

An interesting D-lemma: what is all the excitement about vitamin D?

More than metabolic: Considering the broader paleoepidemiological impact of vitamin D deficiency in bioarchaeology

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