Vitamin D deficiency and respiratory morbidity among African American very low birth weight infants

Kazzi, S. Nadya J.; Karnati, Sreenivas; Puthuraya, Subhash; Thomas, Ronald

doi:10.1016/j.earlhumdev.2018.02.013

Cited by 17 publications

(29 citation statements)

References 30 publications

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“…The sensitivity analysis showed that no single study changed the pooled results ( Vitamin D levels were significantly lower in the BPD infants compared with the controls (SMD = -1.463; 95% CI -2.900 to -0.027; p = 0.046; Fig 3). The heterogeneity assessment https://doi.org/10.1371/journal.pone.0235332.g001 [38,41] and the mother [15,16,38,41,64,65], which is likely attributable to maternal transfer of vitamin D to the fetus [41]. Vitamin D deficiency has been reported in 40-50% of pregnant females and 45-60% of preterm infants [66][67][68][69].…”

Section: Pooled Meta-analysis Resultsmentioning

confidence: 99%

“…The study selection process and exclusion criteria are described in Fig 1. Of the 128 studies identified initially, 120 were excluded based on review of the title, abstract or full text. The reasons for excluding 17 studies [33,34,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] after full-text review, are provided in Fig 1. The remaining eight studies met the inclusion criteria and were included in the meta-analysis [35,37,38,40,41,43,61,62].…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

“…Among 909 infants, 251 (27.6%) infants were diagnosed with BPD (Table 1). Two studies [40,41] defined BPD as an oxygen dependency at 28 days of age; the remaining studies [35,37,38,43,61,62] defined BPD as oxygen dependency at 36 weeks of postmenstrual age, based on National Institutes of Health consensus [63]. The incidence of BPD vary from 6.6% to 56.8%, 6.6% in the study of Yang et al [61], and 56.8% in the study of Kazzi et al [38].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Among eight studies, four [38,40,41,62] presented results on the association of vitamin D deficiency with BPD; the other four studies [35,37,43,61] assessed the association of vitamin D level with BPD. The four studies that evaluated vitamin D deficiency used 25(OH)D cutoff values of 20 ng/mL(50 nmol/L) [40,41], 10 ng/mL [38], or 12 ng/mL(30 nmol/L) [62]. Vitamin D levels were measured from cord blood or at the time of hospital admission or in the 24 hours before intravenous or oral vitamin D administration.…”

Section: Plos Onementioning

confidence: 99%

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Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

et al. 2020

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Neonatal vitamin D deficiency is common and is associated with development of pulmonary disease in children and adults. While the role of vitamin D in normal lung development is well established, the association between vitamin D deficiency and bronchopulmonary dysplasia (BPD) remains unclear. The present meta-analysis was conducted to evaluate the relationship between vitamin D and BPD. We identified relevant studies (n = 8) using the PubMed, EMBASE, Cochrane Library, and KoreaMed databases and applied the Newcastle-Ottawa Scale to assess the methodological components of each study, and used I 2 statistic to evaluate heterogeneity. Comprehensive Meta-Analysis software version 3.3 was used for the statistical analysis. A total of 909 infants were included, of whom 251 (27.6%) were diagnosed with BPD. We found that both vitamin D deficiency at birth (four studies; OR 2.405; 95% CI 1.269 to 4.560; p = 0.007) and low levels of vitamin D at birth (four studies; standardized mean difference-1.463; 95% CI-2.900 to-0.027; p = 0.046) were associated with BPD. The compiled data suggest that antenatal vitamin D deficiency and low vitamin D levels are associated with neonatal BPD.

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Section: Pooled Meta-analysis Resultsmentioning

confidence: 99%

Section: Literature Search and Study Selectionmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

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Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

et al. 2020

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“…Some researchers are using higher supplementation doses than proposed by guidelines, and are obtaining exceptionally good results [54,57,180]. Evidence supports optimal vitamin D serum levels and supplementation in improving fetal growth and neonatal outcomes [27,49,59,145,174,181,182]. As stated by Curtis et al, evidence tends towards better vitamin D serum levels and supplementation being of overall benefit, but some of the data do not reach statistical significance [183].…”

Section: Screening and Supplementationmentioning

confidence: 99%

The role of vitamin D in perinatology. An up-to-date review

et al. 2021

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The role of vitamin D in perinatology is a subject of major interest in current medicine. There is growing evidence about the role of maternal vitamin D levels in pregnancy outcomes. The aim of this review is to summarize the current literature about the role of vitamin D in perinatology. Evidence from this review suggests associations between low levels of maternal vitamin D and higher risk of certain obstetrical complications. Vitamin D has been found to be related to preeclampsia, gestational diabetes mellitus, low birth weight, and preterm birth. The current literature supports vitamin D supplementation in pregnant women, but more high-quality data are necessary. The problem that remains is how to achieve an optimal 25-hydroxyvitamin D level. To determine the real benefits of vitamin D supplementation in pregnancy, we need high-quality trials in larger groups.

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The association of vitamin D and vitamin E levels at birth with bronchopulmonary dysplasia in preterm infants

Liu

et al. 2021

Pediatric Pulmonology

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BackgroundDespite improvements made in neonatal care, bronchopulmonary dysplasia (BPD) is still the most common respiratory disease in preterm infants. The relationship between the blood contents of vitamin D/E in premature infants and BPD is still controversial.MethodsPreterm infants were recruited as the research subjects. On the basis of the inclusion and exclusion criteria, a total of 133 eligible cases were finally included. A total of 63 preterm infants with a clear diagnosis of BPD and 5 preterm infants who died before the diagnosis of BPD were in the case group, and 65 non‐BPD preterm infants with equivalent baseline characteristics were in the control group. The BPD group included 38 cases in Grade Ⅰ, 18 cases in Grade Ⅱ, and 12 cases in Grade Ⅲ. The contents of vitamin D and E in the cord blood of different groups were detected by high‐performance liquid chromatography and enzyme‐linked immunosorbent assay. Correlation analysis adopted the Pearson correlation analytic method.ResultsThe serum vitamin D and E levels at birth were remarkably lower in the BPD group than the non‐BPD group, both of which were also correlated with the severity of BPD. The vitamin D and E contents were negatively correlated with the oxygen support duration required for premature infants with BPD.ConclusionThis study deepens our understanding of the field of BPD pathogenesis by demonstrating an association between vitamin D/E deficiency and BPD severity, suggesting that vitamin D and E might have potential clinical value in the prognosis and treatment of BPD.

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Vitamin D deficiency and respiratory morbidity among African American very low birth weight infants

Cited by 17 publications

References 30 publications

Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

The role of vitamin D in perinatology. An up-to-date review

The association of vitamin D and vitamin E levels at birth with bronchopulmonary dysplasia in preterm infants

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