Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI

Polyzos, Nikolaos P.; Anckaert, Ellen; Guzmán, Luis; Schiettecatte, Johan; Landuyt, Lisbet Van; Camus, Michel; Smitz, Johan; Tournaye, Herman

doi:10.1093/humrep/deu156

Cited by 111 publications

(102 citation statements)

References 26 publications

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“…Only eight of the 34 articles retrieved from PubMed met criteria (Fig. 2) [66][67][68][69][70][71][72][73]. Reference lists of chosen studies and narrative reviews were cross-referenced to find additional studies.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

“…Vitamin D deficiency was defined as <20 ng/mL in accordance with the Endocrine Society guidelines [7], and also consistent with the definition utilized by the majority the trials included in this review [67][68][69][70][71][72]. The study by Polyzos et al [73] was selected for utilization of clinical pregnancy and ongoing pregnancy rates for mathematical modeling secondary to reporting the largest cohort, recency of publication and attempting to control for embryo quality and quantity by including single blastocyst ART cycles only. CP rates in vitamin D deficient versus vitamin D not deficient women undergoing ART were 41 and 54 %, respectively and ongoing pregnancy rates (utilizing live birth rates reported) of 35 and 48 % respectively.…”

Section: Cost-benefit Analysismentioning

confidence: 99%

“…age, sex, BMI, race, comorbidities, etc.). The prevalence of vitamin D deficiency in US reproductive age females undergoing ART (65 %) was derived from Polyzos et al [73] as well as previously described by Mitchell et al [3] (31 %).…”

Section: Cost-benefit Analysismentioning

confidence: 99%

“…In the largest and most recent study, Polyzos et al [73] sought to determine the effect that vitamin D deficiency has on pregnancy rates among women undergoing IVF/ICSI (intracytoplasmic sperm injection) with Day 5 single embryo transfer (SET). In their study, serum vitamin D concentrations were measured retrospectively in 368 infertile women who underwent SET on Day 5.…”

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 99%

“…Unlike the previously discussed studies, Polyzos and colleagues [73] only divided women into two divisions: vitamin D deficient (<20 nL/mg) and not vitamin D deficient (≥20 nL/ mg). Overall, 46 % of patients achieved CP.…”

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 99%

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Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

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Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

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