Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men

Jensen, Martin Blomberg; Lawaetz, Jacob Gerner; Andersson, Anna‐Maria; Petersen, Jørgen Holm; Nordkap, Loa; Bang, Anne Kirstine; Ekbom, Pia; Joensen, Ulla Nordström; Prætorius, Lisbeth; Lundstrøm, Peter; Boujida, Vibeke Hartvig; Lanske, Beate; Juul, Anders; Jørgensen, Niels

doi:10.1093/humrep/dew152

Cited by 104 publications

(104 citation statements)

References 40 publications

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“…Prolactin receptors have been found in Leydig and Sertoli cells in male testes, and high serum PRL levels reduce spermatogenesis, sperm motility and quality by reducing the pulsatile release of FSH, LH and testosterone (Blomberg et al, ; Boisen et al, ; Zhu et al, ). In our study, serum PRL levels were significantly elevated in the infertile groups than in the fertile group.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D is known to be effective on cellular growth, glucose metabolism and immune functions, and its deficiency can cause to insulin resistance and diabetes, cancer, cardiovascular disease, autoimmune disease, chronic pain and physiological disorders, as well as polycystic ovary syndrome, endometriosis and breast and ovarian cancer in women (Blomberg et al, ; Gorkem, Inal, & Inal, ). The enzymes necessitated in the metabolism of VDR and vitamin D have been found in male epididymis, seminal vesicle, prostate, germ and Leydig cells, and spermatozoa and have been reported to function in spermatogenesis, sperm maturation and sex hormone yield; in decreased fertility; and in vitamin D deficiency (Blomberg, ).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

İnal¹,

İnal²,

Mermer³

et al. 2020

Andrologia

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Our aim was to explore the existence of a possible relationship of sperm motility with serum 25‐hydroxyvitamin D3 (25‐OH VD) levels and with ischaemia‐modified albumin (IMA) levels in infertile Turkish men. A total of 30 men with nonobstructive azoospermia (no spermatozoa in ejaculate), 30 men with oligospermia (total progressive motile sperm count (TPMSC) <15 × 106/ml) and 33 fertile men with normospermia (with at least one child, as the control group) were enrolled in the study. The mean 25‐OH VD levels for groups 1, 2 and 3 were 9.31 ± 6.46, 19.71 ± 12.80 and 30.52 ± 12.49 respectively (p < .05). There was a statistically significant difference in serum IMA levels among the groups (479.32 ± 307.56 vs. 296.37 ± 127.27 vs. 150.04 ± 81.05, respectively; p < .05). A positive correlation between serum 25‐OH VD levels and TPMSC, and a negative correlation between TPMSC and serum IMA levels were determined. Infertile men had lower serum 25‐OH VD and higher IMA levels than fertile men, with a positive correlation between serum 25‐OH VD levels and TPMSC, and a negative correlation between TPMSC and serum IMA levels. Vitamin D supplementation may increase the sperm motility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

İnal¹,

İnal²,

Mermer³

et al. 2020

Andrologia

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“…Poor semen quality is an important contributor to this problem and between 20 and 50% of infertile couples have been found to have one or more abnormal semen parameters (Agarwal et al ., ). Associations between vitamin D and semen quality have been examined in several studies (Blomberg Jensen et al ., , ; Ramlau‐Hansen et al ., ; Hammoud et al ., ; Tartagni et al ., ; Abbasihormozi et al ., ; Akhavizadegan & Karbakhsh, ). Some of them found a positive association between vitamin D concentration and sperm motility (Blomberg Jensen et al ., , ; Abbasihormozi et al ., ) and sperm concentration in fertile and infertile men (Akhavizadegan & Karbakhsh, ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status is not associated with reproductive parameters in young Spanish men

et al. 2019

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Background Relatively low sperm count was reported among young Spanish men in 2013. Several potential culprits have been suggested as explanations for reported trends in sperm counts in Western men, including lifestyles. Although controversial, some studies suggest that semen parameters, such as low sperm motility or abnormal morphology, may be associated with low serum vitamin D levels. Objectives To evaluate associations between semen parameters and reproductive hormones and serum 25‐hydroxyvitamin D (25OHD) status in young Spanish men and to examine these associations in relation to dietary intake of vitamin D. Materials and methods This cross‐sectional study includes 198 university students recruited in 2010–2011 in southern Spain, who provided samples of blood and semen and food frequencies. Semen quality was evaluated by measuring volume, concentration, sperm counts, motility, and morphology, according to the WHO guidelines. Serum samples were analyzed for total 25OHD and reproductive hormones, including FSH, LH, testosterone, inhibin B, and estradiol. Dietary vitamin D intake was assessed using a validated food frequency questionnaire. Associations with semen quality and reproductive hormones were examined using linear regression, adjusting for potential confounders. Results Almost all men had adequate levels of serum vitamin D ‐ only three men (1.5%) were vitamin D deficient (<30 nmol/L) and 17% were insufficient (<50 nmol/L). However, dietary vitamin D intakes were relatively low (below recommended 600 IU/day in 99% of men). Neither dietary intake nor serum vitamin D levels were associated with any sperm parameter or any reproductive hormone (all p ≥ 0.09). Discussion We did not observe an association between vitamin D status and any reproductive parameter in our study population. Conclusions Our results suggest that serum vitamin D levels are sustained in Spanish men despite low dietary intake and therefore low vitamin D does not explain the poor semen quality previously observed in these young Spanish men.

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“…The lack of PTH response indicates that calcium in conjunction with other factors may blunt the normal PTH response. Calcium is a known regulator of 1‐alpha hydroxylase activity and PTH secretion . Albumin corrected calcium increased significantly after surgery and could theoretically augment the observed 35% decrease in serum 1,25(OH) 2 D 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Blood samples were handled according to protocol, put on ice, and centrifuged before serum was frozen. Vitamin D metabolites (25‐OHD and 1,25(OH) 2 D 3 ) were measured by isotope dilution liquid chromatography tandem mass spectrometry (LC‐MS/MS) as described previously . The used methodology separates 7α‐hydroxy‐4‐cholesten‐3‐one from 25‐OHD but not the epimer of 25‐OHD.…”

Section: Methodsmentioning

confidence: 99%

Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study

et al. 2018

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Surgical stress reduces concentrations of most proteins in serum and necessitates a rapid adjustment of hormones dependent on protein binding. Activation of vitamin D by renal 1α‐hydroxylation is dependent on protein binding because 1,25‐dihydroxyvitamin D (1,25(OH)2D3) is formed after megalin‐mediated reabsorption of 25‐hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP). Postoperative alterations in serum concentrations of DBP and albumin may therefore impair 1,25(OH)2D3 production. Our objective was to determine sex‐specific changes in serum concentrations of vitamin D metabolites and sex steroids 2, 6, 24, and 48 hours and 3 weeks postoperatively. Fourteen women and eleven men aged 45 to 77 years without severe comorbidities undergoing unilateral total knee arthroplasty participated in this prospective study in a tertiary center for arthroplasty (trial ID: NCT02336932). The main outcome measures were total and free serum concentrations of 25OHD, 1,25(OH)2D3, 24,25‐dihydroxyvitamin‐D, DBP, albumin, sex hormone binding globulin (SHBG), calcium, and parathyroid hormone (PTH). Serum albumin and SHBG decreased postoperatively (Δalbumin48h −18% [−22%; −14%]). Unexpectedly, concentrations of DBP and 25OHD remained unaltered, but 1,25(OH)2D3 declined postoperatively. 1,25(OH)2D3 was 3 weeks after surgery −24% (−40%; −8%) lower than preoperative levels, whereas 24,25‐dihydroxyvitamin‐D remained unchanged in postmenopausal women. The calculated conversion rate of 25OHD to 1,25(OH)2D3 was strongly associated with serum 25‐OHD and PTH preoperatively, whereas serum calcium was most predictive postoperatively. In conclusion, surgery had no effect on serum concentrations of DBP, 25OHD, and PTH, whereas production of 1,25(OH)2D3 was markedly reduced. Further studies are needed to determine duration and putative outcome effects of this postoperative 1,25(OH)2D3 deficit in women, which in part may be due to discordance in CYP27B1 and CYP24A1 activity. © 2018 American Society for Bone and Mineral Research.

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Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men

Abstract: 8 March 2011.

Cited by 104 publications

References 40 publications

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

Vitamin D status is not associated with reproductive parameters in young Spanish men

Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study

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