Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus

Bonakdar, Zahra Sayed; Jahanshahifar, L; Jahanshahifar, F; Gholamrezaei, Ali

doi:10.1177/0961203311405703

Cited by 82 publications

(78 citation statements)

References 18 publications

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“…42 On these basis 1.25(OH)D appears able to regular and probably to contain autoimmune pathological mechanisms. In particular, as regards systemic lupus erythematosus, several studies have confirmed a relationship between low 25(OH)D levels and enhanced disease activity, 21 however, to date there is no high-level evidence to support that vitamin D supplementation may prevent or influence this disease. Other studies were carried out on possible influence of vitamin D status on rheumatoid arthritis without finding any relationship between 25(OH)D and levels of rheumatoid factor or anti-cyclic citrullinated peptide antibodies, 43 whereas an increased incidence in deficiency was found only in undifferentiated arthritis.…”

Section: Immunomodulation Effectmentioning

confidence: 99%

“…Immune system Hypovitaminosis D inhibits maturation of monocyte-derived dendritic cells 20 Low 25(OH)D levels are associated with SLE 21 Oncological diseases 25(OH)D reduces aromatase expression reducing breast cancer growth 22 Low 25(OH)D is associated with high incidence of cancers of colon, 23 breast and prostate 24 High dosage (1000 IU/d) of vitamin D can reduce the risk for total cancer 25 BMD, bone mineral density; SLE, systemic lupus erythematosus. of type 2 diabetes mellitus, hypertension, hyperlipidemia, and peripheral vascular disease, coronary artery disease, myocardial infarction, heart failure, and stroke.…”

Section: Potential Role Of Vitamin D In Older Peoplementioning

confidence: 99%

“…It is known that vitamin D has a wide range of biological actions (Table 2), [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] and that vitamin D receptor is present in most tissues and cells in the body. 26 As a result, it is not unexpected that multiple studies 27 have associated vitamin D deficiency with cardiovascular diseases, type 2 diabetes, hypertension, many types of cancer, rheumatoid arthritis, Crohn's disease, multiple sclerosis, asthma, and infectious diseases.…”

Section: Vitamin D and Extraskeletal Diseasesmentioning

confidence: 99%

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Potential role of vitamin D in prevention of skeletal and extraskeletal diseases in older people

Montagnani

Nardi²,

Cercignani

et al. 2015

Ital J Med

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Vitamin D and calcium are essential for bone health. An adequate calcium-phosphorus product determines a high quality mineralization long lifetime. In older people, both calcium and vitamin D levels may be lower causing osteomalacia and/or osteoporosis with a higher risk of fracture. Epidemiological data have clearly associated serum vitamin D lower levels (deficiency) with bone fracture in older people, however, not univocal data exist in regard to a beneficial effect of vitamin D supplementation in general population. Although not systematic, the present review aims to make a narrative synthesis of the most recent published data on vitamin D effect not only on bone, classical target associated with vitamin D studies, but namely on extraskeletal diseases. In fact, recently, there has been an increasing interest on this latter issue with surprising findings. Vitamin D, and in particular its deficiency, seems to have a role in pathophysiological pathways in several diseases involving cardiovascular, central nervous system and neoplastic process. On the other hand, vitamin D supplementation may modify the outcome of a wide range of illnesses. Up to date the data are conflicting mainly because of difficulty to establish a consensus on the threshold of vitamin D deficit. The US Institute of Medicine recommends to distinguish a level of insufficiency [defined as 30-50 nmol/L or 16-25 ng/mL of 25(OH)D] and another of deficiency identified by 25(OH)D levels lower than 30 nmol/L (or <16 ng/mL). This latter level is considered a minimum level necessary in older adults to minimize the risk of falls, fracture and probably to have some effects of vitamin D supplementation in extraskeletal diseases. Although there are no absolute certainties in such issue, the most recent data suggest that vitamin D deficiency, and its supplementation, may play an important role in a wide range of diseases other than in bone metabolic diseases in older but not in general population. For such reason a widespread measurement of vitamin D levels in general population, and not only in older, seems to be inappropriate and it could induce an overuse of vitamin D supplementation in situations in which its efficacy and cost-effectiveness have not been proven.

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Section: Immunomodulation Effectmentioning

confidence: 99%

Section: Potential Role Of Vitamin D In Older Peoplementioning

confidence: 99%

Section: Vitamin D and Extraskeletal Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Potential role of vitamin D in prevention of skeletal and extraskeletal diseases in older people

Montagnani

Nardi²,

Cercignani

et al. 2015

Ital J Med

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“…Although studies of 25-hydroxyvitamin D [25-(OH)D] levels and disease activity in patients with SLE have not had consistent results, most cross-sectional studies show an inverse relationship between the levels of vitamin D and disease activity. [6][7][8][9][10][11][12] Although the association between disease activity and serum levels of 25-(OH)D has been demonstrated in adults, considerably less is known about this relationship in children with SLE. The aims of this study were to evaluate the vitamin D status in pediatric patients with SLE and to examine whether there is an association between the serum levels of 25-(OH)D and disease activity in this autoimmune disease.…”

mentioning

confidence: 99%

Vitamin D Levels and Disease Activity in Children with Systemic Lupus Erythematosus

et al. 2014

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Objectives: This study aims to evaluate the association between vitamin D deficiency and disease activity in children with juvenile systemic lupus erythematosus (SLE). Patients and methods:A total of 16 children (13 girls and 3 boys; mean age 14.47 years; range 5-18) with SLE who were under followup in our clinic were included in this study. The medical records of the children along with the demographic data, disease duration, treatments received, disease activity, and 25-hydroxyvitamin D [25-(OH)D] levels were evaluated. Systemic lupus erythematosus disease activity (SLEDAI) scores were calculated on the day the serum samples were drawn. Results:The median follow-up period was 30 (range 9 to 55) months. The mean serum vitamin D level was 22.04±16.75 ng/ml. Vitamin D deficiency (serum vitamin D level of <15 ng/ml) was found in half of the patients. Six of them had significantly lower vitamin D levels (≤10 ng/ml). A significant negative correlation between the serum concentrations of vitamin D and the SLEDAI scores was found (r= -0.711, p=0.002). Conclusion:Our study results show that there is a strong negative association between disease activity and vitamin D deficiency in children with SLE. The vitamin D levels of these patients should be evaluated on a regular basis, and vitamin D supplements should be given, if necessary. Vitamin D is an essential steroid hormone that has a primary role in mineral metabolism, skeletal health, and the immune system.1 Since an epidemic of vitamin D deficiency has recently been recognized, many publications have revealed an association between vitamin D deficiency and several diseases with high morbidity and mortality.2 Although the precise etiologic mechanisms are unclear, it is becoming apparent that unrecognized vitamin D deficiency contributes to the increasing incidence and severity of many chronic health conditions. In addition, evidence is accumulating which suggests that vitamin D also plays a key part in the pathogenesis and progression of autoimmunity.1,3 Vitamin D receptors are found on several immune cells, and in vitro studies have shown that vitamin D metabolites modulate T cell proliferation and dendritic cell function by inhibiting the development of T helper 1 cells (Th1) and Th17 cells while promoting the growth of Th2 and T regulatory (Treg) cells. In B cells, vitamin D inhibits antibody secretion and autoantibody production, and vitamin D has the overall effect of immunosuppression.

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“…Apart from its main function, which is calcium and bone metabolism, vitamin D is also necessary for the normal function of other organs and systems [4][5][6]. Calcitriol acts on target cells by binding to a nuclear receptor VDR (vitamin D receptor).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D3 levels in healthy people, including a group aged over 60, in relation to BMI

Tokarski¹,

Godala²

2017

J Pre Clin Clin Res.

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Tokarski S, Godala M. Vitamin D3 levels in healthy people, including a group aged over 60, in relation to BMI. J Pre-Clin Clin Res. 2017; 11(1): 25-29. doi: 10.26444/jpccr/75296 Abstract Vitamin D plays a role not only in the remodeling of bone, but also in functions involving other organs. Its tissue availability depends on dermal synthesis and/or ingestion from diet, as well as on the amount of adipose tissue binding vitamin D into its cells. This study evaluates vitamin D concentrations in relation to body-mass index (BMI) in healthy people aged over 60 and living in the Subcarpathian Province of southeastern Poland. The study involved 246 participants -172 women (69.9%), 74 men (31.1%), with an average age of 6.9 (±11.9). The mean concentrations of vitamin D, assessed with ECLIA method, was 18 ng/ml, which indicates a marked deficiency in vitamin D. Defined vitamin D deficiency (<20ng/ml) was noted in 62% of participants without any difference between males and females. There was no correlation between BMI and vitamin D deficiency in the studied group. The results suggest the need for vitamin supplementation in healthy people aged over 60 according to the guidelines.

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Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus

Cited by 82 publications

References 18 publications

Potential role of vitamin D in prevention of skeletal and extraskeletal diseases in older people

Potential role of vitamin D in prevention of skeletal and extraskeletal diseases in older people

Vitamin D Levels and Disease Activity in Children with Systemic Lupus Erythematosus

Vitamin D3 levels in healthy people, including a group aged over 60, in relation to BMI

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