Vitamin D Deficiency and its Relation to Underlying Stroke Etiology in Ethnic Asian Ischemic Stroke Patients

Silva, Deidre Anne De; Talabucon, Loreto Pascual; Ng, Ebonne Yulin; Ang, Elaine; Tan, Eng King; Lee, Wei Ling

doi:10.1111/j.1747-4949.2012.00958.x

Cited by 4 publications

(4 citation statements)

References 1 publication

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“…The mean (AESD) vitamin D level for all stroke patients was 53.75 AE 21.24 nmol/l; the mean (AESD) vitamin D levels in normal subjects, non-PSD patients and PSD patients were 65.14 AE 19.70, 57.36 AE 21.48 and 44.93 AE 17.94 nmol/l, respectively. These results are similar to the findings of a previous study in the Asian population [20]. A significant intergroup difference in serum vitamin D within 24 h after admission was found (F = 17.718, P < 0.001).…”

Section: Resultssupporting

confidence: 91%

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Low serum levels of vitamin D are associated with post‐stroke depression

Han

Lyu

Sun

et al. 2014

Euro J of Neurology

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Section: Resultssupporting

confidence: 91%

“…Serum levels of vitamin D within 24 h after admission were found to be significantly lower in stroke patient groups than in normal controls, which is consistent with previous studies [16,20]. An association between low vitamin D levels and the development of PSD was also found.…”

Section: Discussionsupporting

confidence: 91%

Low serum levels of vitamin D are associated with post‐stroke depression

Han

Lyu

Sun

et al. 2014

Euro J of Neurology

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“…Serum levels of vitamin D within 24 hours of admission were found to be significantly lower in stroke patient groups than in normal controls, which is consistent with findings of previous studies, which include the Asian population. 17,21 An association between low vitamin D levels and the development of DVT was also found. In a large study comprising 18 791 participants with a 30-year follow-up, decreased 25(OH)D levels during the seasonal change from summer to winter led to an increase in the risk of VTE adjusted for age, sex and other factors.…”

Section: Discussionmentioning

confidence: 87%

Low Vitamin D Levels Are Associated With the Development of Deep Venous Thromboembolic Events in Patients With Ischemic Stroke

2018

Clin Appl Thromb Hemost

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The objective is to determine whether a low serum 25-hydroxyvitamin D (25(OH)D) level is associated with an increased incidence of deep venous thromboembolic events in patients with ischemic stroke. One hundred eighty persons admitted consecutively for inpatient rehabilitation at the Department of Rehabilitation of the First Affiliated Hospital of Wenzhou Medical University with a diagnosis of ischemic stroke from January 2015 to December 2015 were enrolled. The following demographic data were collected: age, sex, body mass index, and history of risk factors. The levels of 25(OH)D and the presence of deep vein thrombosis (DVT) by routine duplex imaging were also recorded. The value of 25(OH)D needed to predict DVT was analyzed using logistic regression analysis, after adjusting for the possible confounders. We found that 80% of patients admitted to the acute inpatient rehabilitation unit had low levels of vitamin D. Forty-seven patients had DVT, and the incidence of DVT was 26.1% within 3 weeks after the stroke event. With all patients taken together, DVT occurrence as a dependent variable with the sufficient group as the reference used for vitamin D levels in the logistic analysis, deficiency of vitamin D was independently associated with the development of DVT (odds ratio = 4.683, 95% confidence interval: 1.396-15.703, P = .012). In conclusion, low serum 25(OH)D levels were independent predictors of DVT in patients with ischemic stroke during inpatient rehabilitation stay in China. This finding reveals the critical role played by 25(OH)D in the pathogenesis of DVT.

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“…According to the previous research, interleukin-1β was significantly increased in the peripheral blood of IS patients compared to the control group [23][24][25]. Recently, an important relationship between the pathogenesis of neurodegenerative disorders and Vitamin D deficiency has been reported [26][27][28][29][30]. Vitamin D has shown a key adjusting role in inflammation and immune response [31], membrane antioxidant activity [32], and also in synaptic plasticity [33].…”

Section: Introductionmentioning

confidence: 99%

Association of Long Non-Coding RNA Malat1 with Serum Levels of Interleukin-1 Beta and Vitamin D in Patients with Ischemic Stroke

Bayat

Tabrizi

Salehi

et al. 2023

GMJ

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Background:Previous studies have demonstrated the strong association of inflammatory cytokines and vitamin D (VitD) deficiency and ischemic stroke (IS) pathogenesis. Due to the negative correlation between long non-coding RNA (lncRNA) Malat1 and pro-inflammatory factors we decided to investigate the associations between Malat1 expression with serum interleukin-1β (IL-1β), and VitD levels in IS patients. Materials and Methods:In this cross-sectional study, 63 IS patients were included. We used enzyme-linked immunosorbent assays to evaluate the serum levels of VitD and IL-1β. Malat1 expression was evaluated by the real-time polymerase chain reaction test. The associations between Malat1expression with VitD and IL-1β were analysed with linear regression (Stepwise model) and Pearson’s correlation analysis. Results: The Malat1 expression was inversely correlated with stroke severity (r=-0.25, P=0.043). Stepwise regression analysis showed a significant positive relationship between VitD level and Malat1 expression (Beta=0.28, P=0.02), and also showed a non-significant negative relationship between IL-1β and stroke severity. VitD level showed a positive Pearson correlation with Malat1 (r=0.28, P=0.023) and a negative correlation with IL-1β (r=-0.29, P=0.018) while it could not detect a significantly negative correlation with stroke severity. Conclusion: For the first time the associations between Malat1 expression with IL-1β and VitD in IS patients was analyzed. We found a significant positive relationship between VitD and Malat1. This correlation needs to be investigated with a larger sample size to achieve a strong and reliable association between VitD and Malat1.[GMJ.2023;12:e2457]

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Vitamin D Deficiency and its Relation to Underlying Stroke Etiology in Ethnic Asian Ischemic Stroke Patients

Cited by 4 publications

References 1 publication

Low serum levels of vitamin D are associated with post‐stroke depression

Low serum levels of vitamin D are associated with post‐stroke depression

Low Vitamin D Levels Are Associated With the Development of Deep Venous Thromboembolic Events in Patients With Ischemic Stroke

Association of Long Non-Coding RNA Malat1 with Serum Levels of Interleukin-1 Beta and Vitamin D in Patients with Ischemic Stroke

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