Vitamin D Deficiency and its Effects on Patients with Multiple Myeloma

Abstract

Objective: It was aimed to evaluate Vitamin D deficiency and its relationship with chemotherapies, autologous stem cell transplantation, bone density, and fractures in patients with MM in this study. Patients and Method:In this retrospective study, patients who were diagnosed with MM and followed up at the hematology department between June 2014 and December 2014 were evaluated in terms of vit-D level in the blood, retrospectively.Results: Of 31 patients with MM, 19 cases were male. The median age was 63 (Range: 49-90 years). The mean vit-D level was 11.9±7.6ng/ml, and was low in 20 of 33 cases (93%). The vit D level was significantly lower in cases whom a greater number of chemotherapy cycles was administered (p= 0.033). There was no statistically significant relationship between blood vit D level and bone fracture development (p= 0.55), DEXA results (p= 0.703), International Staging System (ISS) stage, and whether ABMT had been performed or not (p= 0.752). Conclusion:Osteoporosis, osteonecrosis and fracture are more observed in MM patients in relation with low vit D level in the blood that is more common in advanced age and corticosteroid use.