Vitamin D deficiency and hyperparathyroidism with severe bone disease

Ingemansson, Stig; Hugosson, Claes H.; Woodhouse, Nicholas

doi:10.1007/bf01655437

Cited by 15 publications

(9 citation statements)

References 8 publications

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“…Other Asian countries similarly reported that this condition remained uncommon with most patients presenting with severe osteitis fibrosa cystica. [6][7][8] In fact, the clinical and pathologic characteristics of patients with primary HPT recently reported from these developing countries mirror those reported in the West a few decades earlier. 8,9 A geographic or causative difference of this condition between different population groups has been proposed.…”

supporting

confidence: 58%

Surgical Treatment for Primary Hyperparathyroidism in Hong Kong

Chan²,

Kung³

et al. 2004

Arch Surg

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Hypothesis: With the introduction of the blood chemistry multichannel autoanalyzer, primary hyperparathyroidism (HPT) is increasingly diagnosed. The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon. Design: Unselected case series. Setting: A tertiary referral endocrine surgical unit. Patients: All patients with primary HPT surgically treated over the past 30 years. Main Outcome Measures: The prevalence of patients per 100000 hospital admissions, clinical presentation, biochemistry study results, pathologic status, and main outcome were compared over three 10-year spans according to the introduction of the multichannel au

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supporting

confidence: 58%

Surgical Treatment for Primary Hyperparathyroidism in Hong Kong

Chan²,

Kung³

et al. 2004

Arch Surg

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“…Exact pathogenesis of this younger age of presentation has not been established. Suboptimal vitamin D nutrition is linked with parathyroid adenoma growth [33] and vitamin D deficiency in this part of the world may be a causative factor. In the current decade, patients presenting with metabolic complications, e.g., hypercalcemic crisis, palpable neck mass and pathological fractures have decreased significantly.…”

Section: Discussionmentioning

confidence: 99%

Changing Profile of Primary Hyperparathyroidism Over Two and Half Decades: A Study in Tertiary Referral Center of North India

Yadav

Mishra

et al. 2018

World j. surg.

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“…Similar clinical and pathological features of this disease have been reported from other developing countries. 22 – 24 …”

Section: Discussionmentioning

confidence: 99%

Primary hyperparathyroidism in north India: a description of 52 cases

Bhansali

Masoodi

Reddy

et al. 2005

Annals of Saudi Medicine

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BACKGROUNDPrimary hyperparathyroidism (PHPT) has a variable clinical expression. Symptomatic PHPT is still the predominant form of the disease in many parts of the world, especially developing countries. Because the clinical profile of the disease has changed from that described in the past, we sought to improve our understanding of the disease in patients in north India.METHODSWe summarized the clinical presentation, biochemical and radiological features, and operative findings from the case records from the last 13 years of 52 patients at a tertiary care centre in north India who had documented PHPT.RESULTSThe male: female ratio was 1: 3.3 with ages ranging from 6 to 60 years (mean±SD, 36.38±12.73). Bone disease (46%), recurrent renal stones (21%) and body aches and pains (21%) were the most common modes of presentation. The lag time varied ranged from 1 month to 16 years. Common clinical manifestations included bone pain (67%), weakness/fatigue (56%), fracture of the long bones (48%), abdominal pain (39%), polyuria (37%) and psychiatric manifestations (23.1%). Hypertension was observed in 42% and a palpable nodule in the neck in 19%. Biochemical features included hypercalcemia (86.5%), hypophosphatemia (65.4%) and hyperphosphatasia (67.3%). Mean intact PTH (±SD) was 809.0±696.3 ng/L with levels significantly lower in patients who had only kidney stone disease as compared with those with bone disease (P=0.017). A single parathyroid adenoma was localized in 50 (98%) patients. Hungry bone disease was seen in 59% patients.CONCLUSIONPHPT in India continues to be a symptomatic disorder with skeletal and renal manifestations at a much younger age.

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Vitamin D deficiency and hyperparathyroidism with severe bone disease

Cited by 15 publications

References 8 publications

Surgical Treatment for Primary Hyperparathyroidism in Hong Kong

Surgical Treatment for Primary Hyperparathyroidism in Hong Kong

Changing Profile of Primary Hyperparathyroidism Over Two and Half Decades: A Study in Tertiary Referral Center of North India

Primary hyperparathyroidism in north India: a description of 52 cases

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